ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "FACS analysis"

  • 2019 American Transplant Congress

    Differences in CMV-Specific CD4 T Cell Population in De Novo Kidney Transplant Recipients Treated with Everolimus-Based Regimen Compared to a Standard Tacrolimus-MPA Regimen: Results from ATHENA

    I. A. Hauser1, S. Marx1, C. Sommerer1, B. Suwelack1, D. Dragun1, O. Witzke1, F. Lehner1, I. Kroeger2, M. Junge2, F. Thaiss1, B. Nashan1, M. Sester1

    1ATHENA, CMV Substudy Group, Germany, 2Novartis, Pharma GmbH, Germany

    *Purpose: The ATHENA trial was designed to compare everolimus [EVR] in combination with tacrolimus [TAC] or cyclosporine A [CyA] vs. a standard regimen of mycophenolic…
  • 2019 American Transplant Congress

    Absence of Protective Innate Lymphoid Cell Type 3 (ILC3) and Persistence of Proinflammatory Innate Lymphoid Cell Subsets Immediately Post-Transplant Plays a Appreciable Role in Early Intestinal Barrier Dysfunction

    J. Kang, L. Belyayev, K. Loh, P. Cha, S. Moturi, K. Khan, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer

    Georgetown University, Washington, DC

    *Purpose: Innate lymphoid cells (ILCs) , the most recently described family of lymphoid cells, play fundamental roles in mucosal barrier immunity, tissue homeostasis, and immune…
  • 2019 American Transplant Congress

    First Report and Mechanistic Analysis of Operational Tolerance after Intestinal Transplant

    J. Weiner1, S. Moturi1, C. Ashokkumar2, K. Khan1, S. Kaufman1, R. Sindhi2, C. Matsumoto1, T. Fishbein1, A. Kroemer1

    1MedStar Georgetown Transplant Institute, Washington, DC, 2University of Pittsburgh, Pittsburgh, PA

    *Purpose: Transplantation tolerance is a highly sought and rarely achieved state in clinical medicine. Defined as long-term stable and acceptable graft tolerance without immunosuppression and…
  • 2019 American Transplant Congress

    Central Role of Graft Resident Memory T Cells in Pathogenesis of GVHD after Bowel Transplantation

    J. Weiner, N. Svetlicky, J. Schmidt, S. Moturi, O. Aguirre, J. Kang, M. Sadat, K. Khan, J. Hawksworth, C. Matsumoto, T. Fishbein, A. Kroemer

    MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Graft-versus-host disease (GVHD) is a relatively common and highly morbid complication after intestinal transplantation. Its pathophysiology remains poorly understood. Resident memory T cells (TRM)…
  • 2019 American Transplant Congress

    Depletional Induction Therapy in Non-Human Primates – Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG

    R. Schmitz1, M. S. Mulvihill1, P. M. Schroder1, Z. Fitch1, F. Leopardi1, D. Magnani2, J. Kwun1, S. J. Knechtle1, A. D. Kirk1

    1Surgery, Duke University Medical Center, Durham, NC, 2University of Massachusetts Medical School, Boston, MA

    *Purpose: Antithymocyte globulins (ATG) have been used in transplantation since the late 1960s to prevent and treat acute allograft rejection. Over the past decade, induction…
  • 2018 American Transplant Congress

    Rituximab Interference in B-Cell Crossmatch: A Problem Solved

    P. Malvezzi,1 O. Senoussi,2 T. Jouve,1 C. De Palma,2 L. Rostaing,1 B. Bardy,2 D. Masson.2

    1Service de Néphrologie, Dialyse, Aphérèses et Transplantation, CHU Grenoble Alpes, Grenoble, France; 2Laboratoire d'Histocompatibilité, EFS Rhone Alpes, Grenoble, France.

    Background: Rituximab is commonly prescribed in ABO- or HLA-incompatible kidney transplantation. When used before transplant it interferes with B lymphocyte complement-dependent crossmatch (CDC CM) or…
  • 2018 American Transplant Congress

    Immune Phenotyping in a Pediatric Multicenter Transplant Study: Suitability of a Pre-Formulated Dry Antibody Panel System

    S. Urschel,1 L. Ionescu,1 T. Blydt-Hansen,3 B. Foster,5 S. Mital,2 U. Allan,2 S. Iveson,3 L. Hamiwka,4 J. Yap,1 V. Phan,5 P. Birk,6 L. West,1 M. Levings.3

    1U of Alberta, Edmonton, Canada; 2Sickkids, Toronto, Canada; 3U of BC, Vancouver, Canada; 4U of Calgary, Calgary, Canada; 5Montreal Children's, Montreal, Canada; 6U Manitoba, Winnipeg, Canada.

    Background:Flow cytometric immune-phenotyping is influenced by cryopreservation and inter-laboratory variability limiting comparability in multi center studies. The Duraclone™ system (DC) provides optimized pre-mixed dry antibody…
  • 2018 American Transplant Congress

    The Impact of Childhood Solid Organ Transplantation on B-Cell Maturation

    L. Ionescu,1 T. Blydt-Hansen,2 B. Foster,7 S. Mital,3 L. Hamiwka,5 U. Allan,3 V. Phan,4 P. Birk,6 C. Morgan,1 S. Urschel.1

    1U of Alberta, Edmonton, Canada; 2U of BC, Vancouver, Canada; 3Hospital for Sick Children, Toronto, Canada; 4U de Montreal, Montreal, Canada; 5U of Calgary, Calgary, Canada; 6U of Manitoba, Winnipeg, Canada; 7McGill University, Montreal, Canada.

    Background:The developing immune system of childhood promotes better graft acceptance and longevity but also higher risk for infections and post-transplant (Tx) lymphoproliferative disorders. This may…
  • 2018 American Transplant Congress

    In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury

    I. Linares,1 A. Bartczak,1 K. Farrokhi,1 D. Kollmann,1 M. Kaths,1 M. Hamar,1 P. Urbanellis,1 S. Ganesh,1 O. Adeyi,2 P. Yip,3 M. Selzner,1 N. Selzner.1

    1Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; 2Department of Pathology, Toronto General Hospital, Toronto, ON, Canada; 3Laboratory of Medicine and Pathobiology, Toronto General Hospital, Toronto, ON, Canada.

    Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…
  • 2018 American Transplant Congress

    Multi-Targeting Desensitization Therapy Alters Peripheral B-Cell Homeostasis and Suppresses Recall Alloantibody Responses

    I. Kim, G. Wu, N-.N. Chai, A. Klein, S. Jordan.

    CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

    Purpose: Occurring of donor specific antibodies (DSA) is injurious to organ transplant. Development of immunotherapies to suppress DSA, therefore, has been one of the strategic…
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