ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Epithelial cells"

  • 2017 American Transplant Congress

    Vimentin Regulates ß-Catenin Translocation During Epithelial to Mesenchymal Transition in Renal Fibrosis.

    R. Lopez-Soler, Z. Wang, A. Divanyan.

    Sugery, Section of Transplantation, Albany Medical Center, Albany, NY

    Introduction: Most renal transplants ultimately fail secondary to chronic allograft nephropathy (CAN). The development of Epithelial to Mesenchymal Transition (EMT) in renal tubular epithelial cells…
  • 2017 American Transplant Congress

    A Novel MyD88 Inhibitor Attenuates Allograft Rejection in Heterotopic Tracheal Transplantation in Mice.

    M. Yang, X. Zhang, G. Chen, Z.-C. Ding, Y. Miao, Y. Yang, P. Zhou.

    Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technolog; Key Lab of Ministry of Education & Ministry of Health of China, Wuhan, Hubei, China

    Background: Obstructive bronchiolitis (OB) characterized by chronic rejection, is the main complication after lung transplantation which limits the long-term survival of the recipients. Innate immune…
  • 2017 American Transplant Congress

    The Impact of Tracheal Epithelial Cells Apoptosis on the Biological Behavior of Bone Marrow Mesenchymal Stem Cells (BMSCs) in OB.

    X. Zhang,1 T. Xia,2 C. Wang,2 K. Jiang,2 J. Wang,2 J. Nie.2

    1Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China; 2Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China

    Background: During the development of obliterative bronchiolitis (OB), extensive extracellular matrix is deposited in the lumen of the bronchioli, and the number of myofibroblasts increases.…
  • 2016 American Transplant Congress

    ER Stress and Loss of GRP78 Expression Provides a Link Between Renal Ischemia/Reperfusion Injury and the Urinary Metabolome.

    C. van Kooten,1 T. Pacchiarotta,2 P. van der Pol,1 J. de Fijter,1 N. Schlagwein,1 D. van Gijlswijk,1 O. Mayboroda.2

    1Nephrology, Leiden University Medical Center, Leiden, Netherlands; 2Centre for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.

    Ischemia/reperfusion injury (IRI) profoundly impacts graft survival following kidney transplantation. Epithelial injury is one of the earliest histological alterations of IRI and is especially observed…
  • 2016 American Transplant Congress

    Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.

    G. Zaza,1 V. Masola,1 G. Gambaro,2 M. Onisto,3 G. Bellin,1 I. Vlodavsky,4 Z. Abassi,5 A. Lupo.1

    1Renal Unit, Department of Medicine, University of Verona, Verona, Italy; 2Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; 3Department of Biomedical Sciences, University of Padova, Padova, Italy; 4Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; 5Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.

    Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
  • 2016 American Transplant Congress

    Mechanisms of Cellular Repopulation within Healthy or Intrinsically Scarred Kidney Extracellular Matrix Scaffolds.

    J. Uzarski,1 C. Deaton,5 H. Ward,2 A. Wandinger-Ness,3 W. Miller,4 J. Wertheim.1

    1Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; 2Department of Internal Medicine, University of New Mexico HSC, Albuquerque, NM; 3Department of Pathology, University of New Mexico HSC, Albuquerque, NM; 4Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL; 5Department of Biology, University of Mexico, Albuquerque, NM.

    Background: While the number of wait-listed patients suffering from kidney failure continues to rise, the number of kidney transplants performed each year has remained stagnant.…
  • 2016 American Transplant Congress

    Engineering a “Hybrid Thymus” to Promote Transplant Tolerance.

    S. AlFadil,1 M.-J. Kim,2 M. Iglesias Lozano,1 B. Oh,1 W. Lee,1 G. Brandacher,1 T. Serworld,2 G. Raimondi.1

    1Plastic & Recnstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD; 2Joslin Diabetes Center, Boston, MA.

    Purpose: Targeting the process of central (thymic) selection of developing T lymphocytes is the key tolerogenic mechanism of bone marrow transplantation (BM-Tx)-based protocols for transplant…
  • 2015 American Transplant Congress

    ILC1 and ILC3 Are the Predominant Intra-Epithelial Lymphoid Populations in Human Small Bowel Grafts

    P. Talayero,1 E. Mancebo,1 J. Calvo-Pulido,2 S. Rodriguez-Muñoz,3 A. García-Sesma,2 C. Loinaz,2 C. Jiménez,2 F. Cano,1 R. Laguna,1 E. Paz-Artal.1

    1Immunology, Hospital 12 Octubre, Madrid, Spain; 2Abdominal Transplantation Surgery, Hospital 12 Octubre, Madrid, Spain; 3Gastroenterology, Hospital 12 Octubre, Madrid, Spain.

    We have shown that differently from native small bowels, NK-like cells (CD45+CD103+CD3-) are the predominant intra-epithelial lymphocytes (IEL) in small bowel grafts (SBG) from 4th…
  • 2015 American Transplant Congress

    Morphometry of the Epithelial-Mesenchymal Transition (EMT) in Subsequent Biopsies from Transplanted Kidney

    R. Świder, A. Perkowska-Ptasińska, A. Stachurska, J. Fabijańska-Mitek, R. Zagożdżon, S. Gruca, J. Gołąb, M. Durlik.

    Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland.

    EMT plays the principal role in the pathogenesis of IF/TA as a consequence in the failure of a transplanted kidney. Many facts suggest that the…
  • 2015 American Transplant Congress

    The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury

    S. Kasimsetty, A. Shigeoka, D. McKay.

    Medicine, UCSD, La Jolla, CA.

    Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…
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