Articles tagged "Epithelial cells"

2017 American Transplant Congress
Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.
N. Rogers,^1,2,3 D. Meijles,³ P. Pagano,³ J. Isenberg.³
¹Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, NSW, Australia; ²Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA; ³Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…
2017 American Transplant Congress
Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.
W. Zhang,¹ Z. Yi,¹ E. Stahl,² M. Menon,¹ K. Keung,³ K. Hao,² P. O'Connell,³ B. Murphy.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; ²Department of Genetics and Genomic Science, Ichan School of Medicine at Mount Sinai, New York, NY; ³Renal Unit, University of Sydney at Westmead Hospital, Sydney, Australia
Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…
2017 American Transplant Congress
Poor Outcome of Polyomavirus -Associated Nephropathy with Glomerular Parietal Epithelial Cells Infected by Polyomavirus.
G. Huang,¹ W. Chen,² J. Qiu,¹ X. Chen,¹ L. Chen,¹ C. Wang.¹
¹Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Background: Bowman's capsular epithelium infected by polyomavirus(Py) in polyomavirus -associated nephropathy (PyVAN) is infrequent and considered as the advanced stage of the disease. The aim…
2016 American Transplant Congress
ER Stress and Loss of GRP78 Expression Provides a Link Between Renal Ischemia/Reperfusion Injury and the Urinary Metabolome.
C. van Kooten,¹ T. Pacchiarotta,² P. van der Pol,¹ J. de Fijter,¹ N. Schlagwein,¹ D. van Gijlswijk,¹ O. Mayboroda.²
¹Nephrology, Leiden University Medical Center, Leiden, Netherlands; ²Centre for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
Ischemia/reperfusion injury (IRI) profoundly impacts graft survival following kidney transplantation. Epithelial injury is one of the earliest histological alterations of IRI and is especially observed…
2016 American Transplant Congress
Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.
G. Zaza,¹ V. Masola,¹ G. Gambaro,² M. Onisto,³ G. Bellin,¹ I. Vlodavsky,⁴ Z. Abassi,⁵ A. Lupo.¹
¹Renal Unit, Department of Medicine, University of Verona, Verona, Italy; ²Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; ³Department of Biomedical Sciences, University of Padova, Padova, Italy; ⁴Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; ⁵Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
2016 American Transplant Congress
Mechanisms of Cellular Repopulation within Healthy or Intrinsically Scarred Kidney Extracellular Matrix Scaffolds.
J. Uzarski,¹ C. Deaton,⁵ H. Ward,² A. Wandinger-Ness,³ W. Miller,⁴ J. Wertheim.¹
¹Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ²Department of Internal Medicine, University of New Mexico HSC, Albuquerque, NM; ³Department of Pathology, University of New Mexico HSC, Albuquerque, NM; ⁴Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL; ⁵Department of Biology, University of Mexico, Albuquerque, NM.
Background: While the number of wait-listed patients suffering from kidney failure continues to rise, the number of kidney transplants performed each year has remained stagnant.…
2016 American Transplant Congress
Engineering a “Hybrid Thymus” to Promote Transplant Tolerance.
S. AlFadil,¹ M.-J. Kim,² M. Iglesias Lozano,¹ B. Oh,¹ W. Lee,¹ G. Brandacher,¹ T. Serworld,² G. Raimondi.¹
¹Plastic & Recnstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD; ²Joslin Diabetes Center, Boston, MA.
Purpose: Targeting the process of central (thymic) selection of developing T lymphocytes is the key tolerogenic mechanism of bone marrow transplantation (BM-Tx)-based protocols for transplant…
2015 American Transplant Congress
ILC1 and ILC3 Are the Predominant Intra-Epithelial Lymphoid Populations in Human Small Bowel Grafts
P. Talayero,¹ E. Mancebo,¹ J. Calvo-Pulido,² S. Rodriguez-Muñoz,³ A. García-Sesma,² C. Loinaz,² C. Jiménez,² F. Cano,¹ R. Laguna,¹ E. Paz-Artal.¹
¹Immunology, Hospital 12 Octubre, Madrid, Spain; ²Abdominal Transplantation Surgery, Hospital 12 Octubre, Madrid, Spain; ³Gastroenterology, Hospital 12 Octubre, Madrid, Spain.
We have shown that differently from native small bowels, NK-like cells (CD45+CD103+CD3-) are the predominant intra-epithelial lymphocytes (IEL) in small bowel grafts (SBG) from 4th…
2015 American Transplant Congress
Morphometry of the Epithelial-Mesenchymal Transition (EMT) in Subsequent Biopsies from Transplanted Kidney
R. Świder, A. Perkowska-Ptasińska, A. Stachurska, J. Fabijańska-Mitek, R. Zagożdżon, S. Gruca, J. Gołąb, M. Durlik.
Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland.
EMT plays the principal role in the pathogenesis of IF/TA as a consequence in the failure of a transplanted kidney. Many facts suggest that the…
2015 American Transplant Congress
The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury
S. Kasimsetty, A. Shigeoka, D. McKay.
Medicine, UCSD, La Jolla, CA.
Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…