2022 American Transplant Congress
Defects in Kim-1 Do Not Result In Delayed Graft Function After Kidney Transplantation
*Purpose: Tissue repair is critical to restore organ function after ischemia-reperfusion injury (IRI) during transplantation. During renal injury, upregulation of kidney injury molecule-1 (KIM-1) transforms…2022 American Transplant Congress
Combined Genome Wide and Single Nuclei Transcriptomics in Posttransplant Acute Kidney Injury Identifies Early Proinflammatory/Profibrogenic Cell Origin
*Purpose: Kidney transplants offer a unique opportunity to evaluate molecular pathways involved in development and response to acute kidney injury (AKI). This prospective study of…2022 American Transplant Congress
Early Il-33 Action on Myeloid Cells is Critical In Resistance to Systemic Candida Albicans Infection
*Purpose: Invasive candidiasis could be a cause of morbidity and mortality in immunocompromised patients with organ or bone marrow transplantation. In this study, we systematically…2022 American Transplant Congress
Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial to Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing iκB-α
*Purpose: Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found Epithelial-mesenchymal transition…2020 American Transplant Congress
Circulatory Extracellular Vesicles from Lung Allograft Recipients with Chronic Lung Allograft Dysfunction Can Induce LKB1 Dependent Epithelial-Mesenchymal Transition
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Extracellular vesicles (EVs) play important role in physiological and pathological conditions. Recently we demonstrated that circulating exosomes (EVs) with lung self-antigens (SAgs) play important…2020 American Transplant Congress
Type 3 Innate Lymphoid Cells Are Associated with a Successful Intestinal Transplant
1MedStar Georgetown Transplant Institute, Washington, DC, 2Georgetown University, Washington, DC
*Purpose: Innate lymphoid cells (ILCs) play fundamental roles in mucosal barrier functionality and tissue homeostasis. We hypothesized that protective IL-22-producing NKp44+ILC3 subsets are reduced under…2020 American Transplant Congress
Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein
Jiangsu Province Hospital, Nanjing, China
*Purpose: Allograft interstitial fibrosis and fibrogenesis significantly exacerbate the progression of chronic allograft disease (CAD) and are essential therapeutic targets. Epithelial‐mesenchymal transition (EMT) is recognized…2019 American Transplant Congress
Epithelial to Mesenchymal Transition: A Cellular Mediator of Ischemic Cholangiopathy after Liver Transplant
1VCUHealth, Richmond, VA, 2Department of Surgery, VCUHealth, Richmond, VA
*Purpose: Epithelial-to-mesenchymal transition (EMT) is a genetic reprogramming that causes epithelial cells to assume a migratory, mesenchymal phenotype, and it is induced by hypoxia. Ischemic…2019 American Transplant Congress
Bortezomib Attenuates the Progression of Epithelial to Mesenchymal Transition through Smurf1 Akt mTOR P70S6K Pathway in Rat Allograft Renal Interstitial Fibrosis Model
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was to detect the effects of Bortezomib and Smurf1 in the EMT and allograft renal interstitial fibrosis.*Methods: Biomarkers of EMT, as well…2019 American Transplant Congress
Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney Transplant
*Purpose: Delayed graft function portends reduced 5-year graft survival and is associated with prolonged cold ischemia (CI). The aim of this study was to determine…
- 1
- 2
- 3
- 4
- Next Page »