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American Transplant Congress abstracts

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Articles tagged "Epithelial cells"

  • 2020 American Transplant Congress

    Circulatory Extracellular Vesicles from Lung Allograft Recipients with Chronic Lung Allograft Dysfunction Can Induce LKB1 Dependent Epithelial-Mesenchymal Transition

    M. Rahman, S. Angara, A. Arjuna, M. Smith, R. Bremner, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Extracellular vesicles (EVs) play important role in physiological and pathological conditions. Recently we demonstrated that circulating exosomes (EVs) with lung self-antigens (SAgs) play important…
  • 2020 American Transplant Congress

    Type 3 Innate Lymphoid Cells Are Associated with a Successful Intestinal Transplant

    J. Kang1, K. Loh1, L. Belyayev1, S. Moturi1, M. Sadat1, K. Khan1, A. Duttargi1, Y. Gusev2, K. Bhuvaneshwar2, H. Ressom2, J. Hawksworth1, C. Matsumoto1, T. Fishbein1, A. Kroemer1

    1MedStar Georgetown Transplant Institute, Washington, DC, 2Georgetown University, Washington, DC

    *Purpose: Innate lymphoid cells (ILCs) play fundamental roles in mucosal barrier functionality and tissue homeostasis. We hypothesized that protective IL-22-producing NKp44+ILC3 subsets are reduced under…
  • 2020 American Transplant Congress

    Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein

    C. Suo, Z. Gui, Z. Wang, J. Zhou, M. Zheng, H. Chen, S. Fei, L. Sun, X. Zhang, M. Gu, R. Tan

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Allograft interstitial fibrosis and fibrogenesis significantly exacerbate the progression of chronic allograft disease (CAD) and are essential therapeutic targets. Epithelial‐mesenchymal transition (EMT) is recognized…
  • 2019 American Transplant Congress

    Absence of Protective Innate Lymphoid Cell Type 3 (ILC3) and Persistence of Proinflammatory Innate Lymphoid Cell Subsets Immediately Post-Transplant Plays a Appreciable Role in Early Intestinal Barrier Dysfunction

    J. Kang, L. Belyayev, K. Loh, P. Cha, S. Moturi, K. Khan, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer

    Georgetown University, Washington, DC

    *Purpose: Innate lymphoid cells (ILCs) , the most recently described family of lymphoid cells, play fundamental roles in mucosal barrier immunity, tissue homeostasis, and immune…
  • 2019 American Transplant Congress

    Soluble C Type Lectin Receptor Protein Inhibition of Natural Killer Cell Mediated Tubular Epithelial Cell Death

    S. Balaji1, B. Fuhrmann2, D. Lian3, H. Diao3, S. Ma3, Z. Zhang3, A. M. Jevnikar3

    1Physiology, Western University, London, ON, Canada, 2Microbiology and Immunology, Western University, London, ON, Canada, 3London Health Sciences Centre, London, ON, Canada

    *Purpose: We have previously shown that Natural Killer (NK) cells can mediate kidney tubular epithelial cell (TEC) death and kidney ischemia-reperfusion injury (IRI) as well…
  • 2019 American Transplant Congress

    Epithelial to Mesenchymal Transition: A Cellular Mediator of Ischemic Cholangiopathy after Liver Transplant

    N. A. Wickramaratne1, R. Li2, R. C. Fyffe-Freil2, T. Tian2, M. J. Mangino2

    1VCUHealth, Richmond, VA, 2Department of Surgery, VCUHealth, Richmond, VA

    *Purpose: Epithelial-to-mesenchymal transition (EMT) is a genetic reprogramming that causes epithelial cells to assume a migratory, mesenchymal phenotype, and it is induced by hypoxia. Ischemic…
  • 2019 American Transplant Congress

    Bortezomib Attenuates the Progression of Epithelial to Mesenchymal Transition through Smurf1 Akt mTOR P70S6K Pathway in Rat Allograft Renal Interstitial Fibrosis Model

    R. Tan, Z. Wang, S. Fei, Z. Han, J. Tao, X. Ju, M. Gu

    No.300 Guangzhou Road of Nanjing, Nanjing, China

    *Purpose: Our study was to detect the effects of Bortezomib and Smurf1 in the EMT and allograft renal interstitial fibrosis.*Methods: Biomarkers of EMT, as well…
  • 2019 American Transplant Congress

    Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney Transplant

    S. Jain1, R. Plenter2, T. Nydam2, A. Jani1

    1Renal Division, University of Colorado, Aurora, CO, 2Transplant Microsurgery Program, University of Colorado, Aurora, CO

    *Purpose: Delayed graft function portends reduced 5-year graft survival and is associated with prolonged cold ischemia (CI). The aim of this study was to determine…
  • 2019 American Transplant Congress

    Inhibition of CXCR3 Expression through Blockade of STAT3 Alpha Signaling Down-Regulate Inflammation of Renal Ischemia-Reperfusion Injury

    J. Kim1, J. Park2, K. Yoo2, J. Moon1, J. Jeong1, C. Lee3, Y. Kim1, S. Yang4

    1Seoul National University College of Medicine, Seoul, Korea, Republic of, 2Dongguk University College of Medicine, Gyeonggi-do, Korea, Republic of, 3Cheju Halla General Hospital, Cheju, Jeju-do, Korea, Republic of, 4Kidney Research Institute, Seoul National University, Seoul, Korea, Republic of

    *Purpose: Signal transducer and activator of transcription 3 (STAT3) is the main mediator of interleukin 6 (IL-6)-type cytokine signaling. Although it exists in two isoforms:…
  • 2018 American Transplant Congress

    Inhibition of Neutrophil Recruitment and Activation Protects Airway Epithelium after Transplantation

    R. Zhang,1 H. Fang,1 Q. Chen,2 J. Ochando,3 Y. Ding,1 J. Xu.1

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Background: Obliterative bronchiolitis (OB) is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases.…
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