ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Epithelial cells"

  • 2022 American Transplant Congress

    Combined Genome Wide and Single Nuclei Transcriptomics in Posttransplant Acute Kidney Injury Identifies Early Proinflammatory/Profibrogenic Cell Origin

    J. McDaniels1, T. Rousselle1, E. Bardhi1, A. Shetty1, E. Akalin2, D. Maluf1, V. Mas1

    1University of Maryland, Baltimore, MD, 2Albert Einstein College of Medicine, Montefiore Medical Ctr, Bronx, NY

    *Purpose: Kidney transplants offer a unique opportunity to evaluate molecular pathways involved in development and response to acute kidney injury (AKI). This prospective study of…
  • 2022 American Transplant Congress

    Early Il-33 Action on Myeloid Cells is Critical In Resistance to Systemic Candida Albicans Infection

    H. Cho1, S. Park1, B. Kwon2, H. Park1, Y. Kim3, J. Lee4, J. Park4, K. Park4, K. Yoo4

    1Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, 2School of Biological Sciences, University of Ulsan, Ulsan, Korea, Republic of, 3Biomedical research center, Ulsan University Hospital, Ulsan, Korea, Republic of, 4Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea, Republic of

    *Purpose: Invasive candidiasis could be a cause of morbidity and mortality in immunocompromised patients with organ or bone marrow transplantation. In this study, we systematically…
  • 2022 American Transplant Congress

    Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial to Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing iκB-α

    Z. Gui1, W. Zijie2, M. Zheng3, M. Gu1, R. Tan3

    1Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China, 2Jiangsu Province Hospital, Nanjing, China, 3Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China

    *Purpose: Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found Epithelial-mesenchymal transition…
  • 2022 American Transplant Congress

    Defects in Kim-1 Do Not Result In Delayed Graft Function After Kidney Transplantation

    R. S. Suri1, J. Lee2, M. Ban3, B. Shrum2, O. Z. Ismail4, S. Leckie5, A. McIntyre3, Q. Xu6, S. H. Lee2, S. de Chickera2, R. A. Hegele2, L. Gunaratnam2

    1Research Institute of the McGill University Health Center, Montreal, QC, Canada, 2Schulich School of Medicine and Dentistry, Western University, Lodnon, ON, Canada, 3Robarts Research Institute, Lodnon, ON, Canada, 4University of Alberta, Edmonton, AB, Canada, 5London Health Sciences Centre, Lodnon, ON, Canada, 6University of Pittsburg Medical Center, Pittsburg, PA

    *Purpose: Tissue repair is critical to restore organ function after ischemia-reperfusion injury (IRI) during transplantation. During renal injury, upregulation of kidney injury molecule-1 (KIM-1) transforms…
  • 2020 American Transplant Congress

    Circulatory Extracellular Vesicles from Lung Allograft Recipients with Chronic Lung Allograft Dysfunction Can Induce LKB1 Dependent Epithelial-Mesenchymal Transition

    M. Rahman, S. Angara, A. Arjuna, M. Smith, R. Bremner, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Extracellular vesicles (EVs) play important role in physiological and pathological conditions. Recently we demonstrated that circulating exosomes (EVs) with lung self-antigens (SAgs) play important…
  • 2020 American Transplant Congress

    Type 3 Innate Lymphoid Cells Are Associated with a Successful Intestinal Transplant

    J. Kang1, K. Loh1, L. Belyayev1, S. Moturi1, M. Sadat1, K. Khan1, A. Duttargi1, Y. Gusev2, K. Bhuvaneshwar2, H. Ressom2, J. Hawksworth1, C. Matsumoto1, T. Fishbein1, A. Kroemer1

    1MedStar Georgetown Transplant Institute, Washington, DC, 2Georgetown University, Washington, DC

    *Purpose: Innate lymphoid cells (ILCs) play fundamental roles in mucosal barrier functionality and tissue homeostasis. We hypothesized that protective IL-22-producing NKp44+ILC3 subsets are reduced under…
  • 2020 American Transplant Congress

    Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein

    C. Suo, Z. Gui, Z. Wang, J. Zhou, M. Zheng, H. Chen, S. Fei, L. Sun, X. Zhang, M. Gu, R. Tan

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Allograft interstitial fibrosis and fibrogenesis significantly exacerbate the progression of chronic allograft disease (CAD) and are essential therapeutic targets. Epithelial‐mesenchymal transition (EMT) is recognized…
  • 2019 American Transplant Congress

    Absence of Protective Innate Lymphoid Cell Type 3 (ILC3) and Persistence of Proinflammatory Innate Lymphoid Cell Subsets Immediately Post-Transplant Plays a Appreciable Role in Early Intestinal Barrier Dysfunction

    J. Kang, L. Belyayev, K. Loh, P. Cha, S. Moturi, K. Khan, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer

    Georgetown University, Washington, DC

    *Purpose: Innate lymphoid cells (ILCs) , the most recently described family of lymphoid cells, play fundamental roles in mucosal barrier immunity, tissue homeostasis, and immune…
  • 2019 American Transplant Congress

    Soluble C Type Lectin Receptor Protein Inhibition of Natural Killer Cell Mediated Tubular Epithelial Cell Death

    S. Balaji1, B. Fuhrmann2, D. Lian3, H. Diao3, S. Ma3, Z. Zhang3, A. M. Jevnikar3

    1Physiology, Western University, London, ON, Canada, 2Microbiology and Immunology, Western University, London, ON, Canada, 3London Health Sciences Centre, London, ON, Canada

    *Purpose: We have previously shown that Natural Killer (NK) cells can mediate kidney tubular epithelial cell (TEC) death and kidney ischemia-reperfusion injury (IRI) as well…
  • 2019 American Transplant Congress

    Epithelial to Mesenchymal Transition: A Cellular Mediator of Ischemic Cholangiopathy after Liver Transplant

    N. A. Wickramaratne1, R. Li2, R. C. Fyffe-Freil2, T. Tian2, M. J. Mangino2

    1VCUHealth, Richmond, VA, 2Department of Surgery, VCUHealth, Richmond, VA

    *Purpose: Epithelial-to-mesenchymal transition (EMT) is a genetic reprogramming that causes epithelial cells to assume a migratory, mesenchymal phenotype, and it is induced by hypoxia. Ischemic…
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