Articles tagged "Eosinophils"

2022 American Transplant Congress
Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance
Y. Guo¹, Z. Mei¹, M. Khalil¹, D. Li¹, A. Banerjee¹, A. Gelman², D. Kreisel², A. Krupnick¹
¹Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, ²Washington University School of Medicine in St Louis, Saint Louis, MO
*Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…
2022 American Transplant Congress
Lung Allograft-Resident Eosinophils Maintain Long-Term Graft Integrity by Restraining Humoral Alloimmunity
Z. Mei¹, Y. Guo¹, D. Li¹, M. Khalil¹, A. Banerjee¹, A. Gelman², D. Kreisel², A. Krupnick³
¹Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, ²Washington University in St. Louis, St. Louis, MO, ³Department of Surgery, University of Maryland, Baltimore, baltimore, MD
*Purpose: The finding that eosinophils facilitate immunosuppression-mediated acceptance of murine lung allograft by downregulating alloreactive CD8+ T cells has been recently described by our group.…
2021 American Transplant Congress
Eosinophils Attenuate Hepatic Ischemia Reperfusion Injury in Mice Through St2-Dependent Il-13 Production
Y. Yang, Y. Wang, M. Wang, J. Jeong, L. Xu, Y. Wen, C. Emontzpohl, W. Dar, C. Ju
Department of Anesthesiology, McGovern Medical School University of Texas Health Science Center at Houston, Houston, TX
*Purpose: The purpose is to investigate the functional role of eosinophils during hepatic ischemia and reperfusion injury (IRI).*Methods: Mice with antibody-induced eosinophil depletion and two…
2020 American Transplant Congress
Eosinophils Maintain Lung Allograft Tolerance by Sequestering CD8+ T Cells in Bronchial Associated Lymphoid Tissue
Z. Mei¹, Y. Guo¹, A. Hata¹, A. Banerjee¹, D. Li¹, A. Manafi¹, B. Mahgoub¹, D. Kreisel², A. Gelman², A. S. Krupnick¹
¹Department of Surgery, University of Virginia, Charlottesville, VA, ²Department of Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: It has been recently described that eosinophils can facilitate immunosuppression-mediated acceptance of murine lung allografts. But the role of eosinophils in long term maintenance…
2020 American Transplant Congress
Co-Stimulatory Blockade Immunosuppression Facilitates Lung Allograft Acceptance Through an Increase in Local IL-5 Production by Type 2 Innate Lymphoid Cells
Y. Guo, Z. Mei, A. Hata, B. Mahgoub, D. Li, A. Manafi, A. Banerjee, A. Gelman, D. Kreisel, A. Krupnick
Surgery, University of Virginia, Charlottesville, VA
*Purpose: We have recently demonstrated that co-stimulatory blockade (CSB)-induced mouse lung allograft acceptance depends on a rapid influx of eosinophils that function to downregulate T…
2015 American Transplant Congress
Eosinophilic Gastrointestinal Disease in Pediatric Liver and Kidney Transplant Recipients
S. Mohammad,¹ J. Bush,² K. Amsden,¹ A. Kagalwalla,¹ H. Melin-Aldana,² N. Arva.²
¹Pediatrics, Northwestern University, Chicago; ²Pathology, Northwestern University, Chicago.
Eosinophilic gastrointestinal disease (EGID) has been associated with immunosuppression use in solid organ transplant recipients. However, its relationship to the post-transplant clinical course is unknown.…