ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Engraftment"

  • 2017 American Transplant Congress

    Tolerogenic Potential, Migratory Pathways, Engraftment and Long-Term Survival of Human Hematopoietic Chimeric Cells – A Novel Strategy to Induce Tolerance in Transplantation.

    M. Siemionow, E. Bryndza Tfaily, E. Szilagyi, J. Cwykiel, S. Uygur, M. Czerwinski.

    Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL

    Background: Cell-based therapies represent a new promising strategy for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…
  • 2017 American Transplant Congress

    Confirmation of the Safety of Cryopreserved Human Cord Blood Derived Di-Chimeric Cells in the NSG Mouse Model.

    J. Cwykiel, N. Filipek, E. Szilagyi, E. Tfaily, M. Siemionow.

    Orthopaedics, University of Illinois at Chicago, Chicago, IL

    Background: Cell therapies are a promising approach for tolerance induction in Vascularized Composite Allotransplantation (VCA). Thus, we have developed a new supportive therapy of ex…
  • 2017 American Transplant Congress

    Delayed Tolerance Induction Protocol for Vascularized Composite Allografts in Non-Human Primates: The Immunomodulatory Effect of Donor Bone Marrow Transplantation Does Not Prevent the Development of Chronic Rejection in the Absence of Durable Mixed Chimerism.

    Z. Ng, A. Lellouch, A.-R. Gama, I. Schol, I. Rosales, R. Colvin, L. Geoghegan, J. Kurtz, C. Cetrulo.

    Massachusetts General Hospital, Boston, MA

    PURPOSE: Donor bone marrow transplantation (DBMT) has been investigated in experimental and clinical vascularized composite allotransplantation (VCA). With longer-term follow-up, reports of chronic VCA rejection…
  • 2017 American Transplant Congress

    Assessment of Islet Damage During Isolation Utilizing miRNAs and Its Significance with Post-Transplant Outcome in TPIAT.

    P. Saravanan,1 M. Kanak,2 G. Yoshimatsu,1 M. Lawrence,1 B. Naziruddin.3

    1Baylor Scott and White Research Institute, Dallas, TX; 2Virginia Commonwealth University, Richmond, VA; 3Baylor Simmons Transplant Institute, Dallas, TX

    Background: Pancreatic islets with high quality are essential for better endocrine function and post-transplant outcome in total pancreatectomy with islet autotransplantation (TPIAT). The islets are…
  • 2017 American Transplant Congress

    Transplantation of Chimeric Cells of Myoblast and Mesenchymal Stem Cell Origin for Restoration of Muscle Function.

    M. Siemionow, E. Szilagyi, J. Cwykiel, A. Domaszewska-Szostek, A. Heydemann, J. Garcia-Martinez.

    University of Illinois at Chicago, Chicago

    Background: Allogeneic stem cell therapies aim to restore muscle tissue after traumatic loss or muscular dystrophies. Limited engraftment due to rejection is a major challenge.…
  • 2017 American Transplant Congress

    Timing of Mesenchymal Stem Cell Infusions Affects Rejection Free and Overall Islet Allograft Survival.

    N. Kenyon,1 M. Willman,1 D. Han,1 A. Rabassa,1 W. Diaz,1 R. Leeman,1 K. McHenry,2 D. Salomon,3 A. Bartholomew,4 N. Kenyon,1 D. Berman.1

    1Diabetes Research Institute, University of Miami, Miami, FL; 2University of Illinois at Urbana-Champaign, Champaign, IL; 3The Scripps Research Institute, La Jolla, CA; 4University of Illinois at Chicago, Chicago, IL

    We recently demonstrated that autologous, bone marrow-derived mesenchymal stem cells (MSC) promote allogeneic islet engraftment and survival in a streptozotocin induced, cynomolgus monkey model of…
  • 2017 American Transplant Congress

    Suppression of Inflammation by Withaferin A in Cerulein-Induced Pancreatitis Model Results in Improved Syngeneic Islet Engraftment.

    G. Yoshimatsu,1 M. Kanak,2 C. Chang,1 C. Darden,1 M. Lawrence,1 B. Naziruddin.3

    1Baylor Scott and White Research Institute, Dallas, TX; 2Virginia Commonwellth University, Richmond, VA; 3Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: Chronic pancreatitis (CP) is characterized by inflammatory damage to acinar cells followed by islets. In clinical islet autotransplantation, patients with advanced stages of CP…
  • 2016 American Transplant Congress

    Porcine Islets Engineered with SA-FasL Protein Induces Robust Tolerance in Mice through CD4+CD25+FoxP3+ Treg Cells.

    K. Woodward,1 H. Zhao,1 H. Shirwan,1 F. Wang,1 M. Graham,2 B. Hering,2 E. Yolcu.1

    1Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY; 2Schulze Diabetes Institute and Department of Surgery, University of Minnesota, Minneapolis, MN.

    Introduction: We have shown that porcine islets engineered to transiently display SA-FasL protein on their surface establish tolerance in mice following transplantation under the kidney…
  • 2016 American Transplant Congress

    The Function of CD8+TCR– Facilitating Cells and Regulatory T Cells Is Impaired in Flt3-Ligand Knockout Mice.

    Y. Huang, H. Xu, T. Miller, Y. Wen, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Graft CD8+TCR- facilitating cells (FC) enhance engraftment of hematopoietic stem cells (HSC) in allogeneic mouse recipients without causing graft-versus-host disease. FC induce antigen-specific CD4+CD25+FoxP3+ regulatory…
  • 2016 American Transplant Congress

    iNKT Cell Ligands Administered with Bone Marrow Cells Expand Allo-Specific Regulatory T Cells In Vivo and Establish Transplant Tolerance.

    S. Miyairi,1,2 T. Hirai,1 M. Okumi,1 Y. Ishii,3 K. Yamazaki,2 K. Tanabe.1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; 3Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.

    Invariant natural killer T(iNKT) cells have the powerful potential to expand regulatory T cells(Tregs), especially when they are presented α-galactosylceramide(aGC) by B cells. We previously…
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