Articles tagged "Engraftment"

2020 American Transplant Congress
CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction
P. Shrestha, L. Batra, M. T. Malik, M. Tan, E. S. Yolcu, H. Shirwan
Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY
*Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…
2020 American Transplant Congress
Hepatitis B Virus Prophylaxis and Treatment among Hematopoietic Stem Cell Transplant Recipients: Impact on Engraftment and Outcomes
B. Buzo¹, J. Fernandes Ramos², R. Marques Rossetti³, N. Salles⁴, A. Mendrone-Junior⁴, V. Rocha³, A. de Seixas Santos Nastri⁵
¹Division of Infectious Diseases, University of Alberta, Edmonton, AB, Canada, ²Division of Infectious Diseases and Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, ³Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, ⁴Fundacao Pro-Sangue, Sao Paulo, Brazil, ⁵Division of Infectious Diseases, University of Sao Paulo, Sao Paulo, Brazil
*Purpose: Hepatitis B virus infection is a worldwide concern with a broad distribution. It can reactivate in immunocompromised populations such as solid organ and hematopoietic…
2020 American Transplant Congress
Epithelial To Mesenchymal Transition Mediates Engraftment Of Endoderm And Hepatic Progenitor Cells In The Quiescent Liver
W. S. Fagg¹, N. Lui², L. Patrikeev³, O. Saldarriaga*⁴, H. Lerner-Stevenson⁵, V. Popov⁶, M. Motamade³, J. H. Fair¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Surgery, Naiyou Lui, Galveston, TX, ³Ophthalmology, University of Texas Medical Branch, Galveston, TX, ⁴Pathology, Omar Saldarriaga, Galveston, TX, ⁵pathology, University of Texas Medical Branch, Galveston, TX, ⁶Pathology, University of Texas Medical Branch, Galveston, TX
*Purpose: Stem cell transplantation to the liver is a promising therapeutic strategy for a variety of disorders. Hepatocyte transplantation has short term efficacy, but can…
2019 American Transplant Congress
Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney
S. Noel¹, J. T. Kurzhagen¹, S. Lee¹, M. Sadasivam², A. R. Hamad², P. M. Pierorazio³, H. Rabb¹
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Pathology, Johns Hopkins University, Baltimore, MD, ³Urology, Johns Hopkins University, Baltimore, MD
*Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
2019 American Transplant Congress
Pluripotent Stem Cell Differentiation: Delaying Forward Differentiation Signals Maintains Definitive Endoderm Phenotype for Cellular Transplantation
J. Fair¹, M. M. Shoja¹, N. Liu¹, I. Patrikeev², M. Motamedi², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX
*Purpose: Endodermal precursors (EP), derived in vitro from mouse pluripotent stem cell (PSC) sources, are capable of clinically useful engraftment in the unmodified (quiescent) liver…
2019 American Transplant Congress
CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation
M. Song, K. Samy, Q. Gao, R. P. Davis, F. Leopard, Z. Fitch, C. Bennett, G. R. Devi, B. H. Collins, A. D. Kirk
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…
2019 American Transplant Congress
Differentiation and Characterization of Human Endodermal Precursors for Liver Cell Therapies
W. S. Fagg¹, N. Liu¹, M. Shoja¹, I. Patrikeev², M. Motamedi², J. Fair¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX
*Purpose: Mouse pluripotent stem cell (PSC)-derived endoderm precursors (EPs) have small size, endoderm lineage gene expression signatures, and high proliferation rates, that allow engraftment in…
2019 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine DLA-Mismatch Model
B. Swearingen¹, S. Graves², R. Storb², D. W. Mathes¹
¹University of Colorado School of Medicine, Aurora, CO, ²Fred Hutchinson Cancer Research Center, Seattle, WA
*Purpose: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols rely on…
2019 American Transplant Congress
Parathyroid CD34+ Cells Induce Neovascularization of Donor and Recipient Leading to Chimeric Vessel Formation and Improved Engraftment of Co-Transplanted Pancreatic Islets
Y. Kelly¹, C. Ward¹, Q. Duh¹, W. Chang², P. Stock¹, Q. Tang¹
¹UCSF, San Francisco, CA, ²San Francisco Veterans Affairs, San Francisco, CA
*Purpose: We recently showed improved engraftment and diabetes reversal when mature islets or stem-cell-derived beta cells (SCIPC) were co-transplanted with parathyroid gland (PTG). The CD34+…
2019 American Transplant Congress
Can Cxcl8 Inhibitor (reparixin) Improve Islet Engraftment And Clinical Outcomes After Islet Allotransplantation? University Of Chicago Preliminary Results From A Phase 3 Multicenter Randomized, Double-blinded, Prospective Study.
P. Bachul¹, K. Golab¹, L. Basto¹, L. Wang¹, M. Tibudan¹, J. Golebiewska², M. Para¹, L. Perea¹, F. Antic¹, J. Fung¹, P. Witkowski¹
¹University of Chicago Medicine, Chicago, IL, ²Medical University of Gdansk, Gdansk, Poland
*Purpose: Reparixin is a novel CxCR1/2 chemokine receptor-blocking molecule, which has been shown improving islet engraftment in animal models. A multicenter trial was organized to…