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American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2016 American Transplant Congress

    Detection of Endothelial Cell Specific Molecule-1 According to Allograft Status After Kidney Transplantation.

    J.-W. Seo, S.-Y. Kim, Y.-G. Kim, Y.-H. Jeong, Y.-H. Lee, J.-Y. Moon, T.-W. Lee, C.-G. Ihm, S.-H. Lee.

    Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

    To investigate urine ESM-1(endothelial cell specific molecule-1) as well as plasma ESM-1 level from renal allograft recipients, we show whether there is the difference of…
  • 2016 American Transplant Congress

    Everolimus Abrogates C5a and TGFβ Mediated Perycite-to-Myofibroblast Transition (PMT) Inhibiting Vascular Rarefaction.

    G. Castellano, R. Franzin, A. Stasi, C. Divella, L. Gesualdo.

    Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

    Microvascular pericytes have detrimental effects on tubulo-interstitial fibrosis via PMT. However, therapeutic strategies that might interfere with this process are currently lacking. We aimed to…
  • 2016 American Transplant Congress

    Human and Mouse Treg Use Lymphotoxin for Migration Across Lymphatic Endothelium.

    C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore, MD; 2Univerity of Minnesota, Minneapolis, MN.

    Introduction: Lymphotoxin (LT) directs lymphoid organ structure, and LTβ receptor (LTβR) is involved in leukocyte migration into lymph nodes (LN) and thymocyte migration. We previously…
  • 2016 American Transplant Congress

    The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.

    M. Dieudé,1,4,5 C. Bell,2,5 J. Turgeon,1,5 D. Beillevaire,1,4,5 S. Qi,1,5 E. Boilard,3,5 P. Thibault,2,5 M.-J. Hébert.1,4,5

    1Research Centre Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Canada; 2Institute for research in immunology and cancer (IRIC), Montreal, Canada; 3Centre de Recherche du CHU de Québec, Québec, Canada; 4Université de Montréal, Montréal, Canada; 5Canadian National Transplant Research Program, Edmonton, Canada.

    Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…
  • 2015 American Transplant Congress

    Lymphatic Endothelium Uniquely Enhances T Cell Migration to S1P

    C. Brinkman, Y. Xiong, J. Bromberg.

    University of Maryland, Baltimore, MD.

    Introduction: Sphingosine-1-phosphate (S1P) is a signaling sphingolipid that regulates cell egress from lymphoid and non-lymphoid tissues. While S1P has been described as a chemoattractant, its…
  • 2015 American Transplant Congress

    Tandem P-Selectin Glycoprotein Ligand-Immunoglobulin (TSGL-Ig) Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation

    C. Zhang,1 H. Ji,1 Y. Liu,1 X. Shen,1 F. Gao,1 R. Busuttil,1 G. Shaw,2 J. Kupiec-Weglinski.1

    1Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA; 2Quell Pharma Inc., Half Moon Bay, CA.

    Background: Liver endothelial cell (LEC) damage is central in the pathogenesis of hepatic ischemia-reperfusion injury (IRI). LEC detachment/progressed denudation are typical during cold storage and…
  • 2015 American Transplant Congress

    Allogeneic Monocyte–Endothelial Cell Interaction Plays a Critical Role in Initiating Early Pro-Fibrosis Responses

    E. Gall, H. Xu, K. Samy, A. Kirk.

    Surgery, Duke University Medical Center, Durham, NC.

    Chronic allograft nephropathy (CAN), characterized by interstitial fibrosis, vascular intimal thickening, and glomerulosclerosis, has remained as leading cause of allograft failure. The role of innate…
  • 2015 American Transplant Congress

    Lymphotoxin Controls Treg Interactions With Lymphatic Endothelial Cells and Interstitial Migration In Vivo

    C. Brinkman, Y. Xiong, S. Ahmad, J. Bromberg.

    University of Maryland, Baltimore, MD.

    Introduction: Lymphotoxin (LT) coordinates the development, organization and structure of lymphoid organs, and LTβreceptor (LTβR) is involved in thymocyte migration. However, LT has no described…
  • 2015 American Transplant Congress

    Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR

    S. Salehi, E. Reed.

    Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.

    Aim: Antibody-mediated rejection (AMR) persists as a major issue affecting solid organ transplants. The purpose of this study was to investigate the proximal signaling events…
  • 2015 American Transplant Congress

    Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)

    R. Catar,1 C. Luecht,1 M. Simon,1 A. Philippe,1 A. Kusch,1 M. Szczepek,2 P. Hildebrand,2 P. Scheerer,2 D. Dragun.1

    1Nephrology and Intensive Care Medicine, Charité, Berlin, Germany; 2Institute of Medical Physics and Biophysics, Charité, Berlin, Germany.

    Microvascular endothelium is major target for antibodies directed against HLA and non-HLA antigens. Functional antibodies targeting G-protein coupled receptors (GPCRs) such as AT1R or ETAR…
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