ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2016 American Transplant Congress

    Sphingosine 1-Phosphate (S1P) Receptors Differentially Regulate Murine and Human CD4 T Cell Migration Across Lymphatic Endothelium.

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.

    S1P and S1PR1 are used by T cells to migrate from thymus across microvascular endothelium to the blood circulation, and across medullary lymphatic endothelium of…
  • 2016 American Transplant Congress

    A Unique In Vitro Migration Model for Leukocyte Trans-Lymphatic Endothelial Migration.

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.

    Trans-endothelial migration (TEM) is an essential process for leukocyte circulation. While much is known about lymphocyte blood to tissue migration, far less is known about…
  • 2016 American Transplant Congress

    Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.

    R. Finnegan,1 P. Zhu,1 S. Stephenson,1 K. Patel,2 S. Nadig,1,2,3 C. Atkinson.1,2,3

    1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; 2Department of Surgery, Medical University of South Carolina, Charleston, SC; 3South Carolina Investigators in Transplantation, Medical University of South Carolina, Charleston, SC.

    Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…
  • 2016 American Transplant Congress

    HLA Antibody Clonality and Epitopes Dictate Complement Activation.

    K. Thomas,1 N. Valenzuela,1 A. Mulder,2 E. Reed.1

    1Pathology and Laboratory Medicine, UCLA, Los Angeles, CA; 2Leiden University Medical Center, Leiden, Netherlands.

    Background: Alloimmunization results in production of polyclonal donor specific antibodies (DSA) against human leukocyte antigens (HLA), which mediate endothelial cell activation, leukocyte recruitment, and complement…
  • 2015 American Transplant Congress

    Tandem P-Selectin Glycoprotein Ligand-Immunoglobulin (TSGL-Ig) Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation

    C. Zhang,1 H. Ji,1 Y. Liu,1 X. Shen,1 F. Gao,1 R. Busuttil,1 G. Shaw,2 J. Kupiec-Weglinski.1

    1Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA; 2Quell Pharma Inc., Half Moon Bay, CA.

    Background: Liver endothelial cell (LEC) damage is central in the pathogenesis of hepatic ischemia-reperfusion injury (IRI). LEC detachment/progressed denudation are typical during cold storage and…
  • 2015 American Transplant Congress

    Allogeneic Monocyte–Endothelial Cell Interaction Plays a Critical Role in Initiating Early Pro-Fibrosis Responses

    E. Gall, H. Xu, K. Samy, A. Kirk.

    Surgery, Duke University Medical Center, Durham, NC.

    Chronic allograft nephropathy (CAN), characterized by interstitial fibrosis, vascular intimal thickening, and glomerulosclerosis, has remained as leading cause of allograft failure. The role of innate…
  • 2015 American Transplant Congress

    Lymphotoxin Controls Treg Interactions With Lymphatic Endothelial Cells and Interstitial Migration In Vivo

    C. Brinkman, Y. Xiong, S. Ahmad, J. Bromberg.

    University of Maryland, Baltimore, MD.

    Introduction: Lymphotoxin (LT) coordinates the development, organization and structure of lymphoid organs, and LTβreceptor (LTβR) is involved in thymocyte migration. However, LT has no described…
  • 2015 American Transplant Congress

    Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR

    S. Salehi, E. Reed.

    Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.

    Aim: Antibody-mediated rejection (AMR) persists as a major issue affecting solid organ transplants. The purpose of this study was to investigate the proximal signaling events…
  • 2015 American Transplant Congress

    Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)

    R. Catar,1 C. Luecht,1 M. Simon,1 A. Philippe,1 A. Kusch,1 M. Szczepek,2 P. Hildebrand,2 P. Scheerer,2 D. Dragun.1

    1Nephrology and Intensive Care Medicine, Charité, Berlin, Germany; 2Institute of Medical Physics and Biophysics, Charité, Berlin, Germany.

    Microvascular endothelium is major target for antibodies directed against HLA and non-HLA antigens. Functional antibodies targeting G-protein coupled receptors (GPCRs) such as AT1R or ETAR…
  • 2015 American Transplant Congress

    Use of RNA Sequencing for Discovery of Markers of Accommodation in Surveillance Biopsies from Recipients of an ABO-Incompatible Renal Transplant

    A. McLean,2 K. Dominy,1 A. Sosinsky,1 M. Mueller,1 J. Galliford,2 T. Cook,1,2 C. Roufosse.1,2

    1Imperial College, London, United Kingdom; 2Imperial College Healthcare NHS Trust, London, United Kingdom.

    Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…
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