2016 American Transplant Congress
Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.
Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…2016 American Transplant Congress
HLA Antibody Clonality and Epitopes Dictate Complement Activation.
Background: Alloimmunization results in production of polyclonal donor specific antibodies (DSA) against human leukocyte antigens (HLA), which mediate endothelial cell activation, leukocyte recruitment, and complement…2016 American Transplant Congress
Lysosome Ativity Regulates LG3 Export by Apoptotic Cells.
LG3, a C-terminal fragment of perlecan bioactive on vascular cells, has been implicated in aggravation of renal allograft rejection and vascular injury. Recently, we have…2016 American Transplant Congress
Vascular Endothelial Cell Activation by Mitochondria Links Innate and Adaptive Immune Responses to Allograft Injury.
Surgery, Duke University Medical Center, Durham, NC.
Vascular endothelial cells (ECs) are an initial barrier between allografts and the host immune system and play an important role in initiating allograft rejection. Increasing…2016 American Transplant Congress
Tacrolimus as a Tool for Intracellular Assessment of von Willebrand Factor Production by Activated Human Glomerular Endothelial Cells.
Renal Division, University Health Center (CHU) of Quebec, Laval University, Quebec, QC, Canada.
Background: Von Willebrand factor (vWF) is a prothrombotic mediator stored in intracytoplasmic granules within endothelial cells and is released by endothelial exocytosis, leading to microangiopathic…2016 American Transplant Congress
Matrix Metalloproteinase-2 (MMP-2) Activity Protects Against Hepatic Ischemia Reperfusion Injury Through MMP-9-Dependent and MMP-9-Independent Mechanisms.
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix Metalloproteinases (MMPs) are a family of proteinases with key roles in tissue homeostasis, inflammation and repair. We have recently shown that MMP-9 and MMP-2,…2016 American Transplant Congress
Recombinant TSGL-Ig Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation.
Background: Liver endothelial cells (LEC) suffer from ROS-mediated stress in the pathogenesis of liver ischemia-reperfusion injury (IRI). We used a novel recombinant form of soluble…2016 American Transplant Congress
Sphingosine-1 Phosphate Receptor 1 Agonist SEW2871 Ameliorates Hepatocellular Injury on Ischemic Reperfusion in Mice: A New Therapeutic Target.
Introduction: We had reported that activated protein C (APC) administration had cytoprotective effects on hepatic ischemic reperfusion (IR) injury in rat and mice models. Recent…2016 American Transplant Congress
Prolonged Cold Ischemia Time Negatively Impacts Graft and Recipient Survival in a Murine Orthotopic Hindlimb Transplant Model.
Department of Surgery, UCLA Medical Center, Los Angeles, CA.
Purpose: The safe maximum cold preservation time remains unknown in Vascularized Composite Allotransplantation (VCA), yet is of critical clinical significance. VCAs with a large muscular…2016 American Transplant Congress
Hypothermic Machine Perfusion Ameliorates Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells Through Upregulating Expression of Krüppel-Like Factors 2.
Protective mechanisms of hypothermic machine perfusion (MP) remain largely unknown. Vascular branches of the renal arteries of 6 kidneys in 320 donors were unexpectedly injured…
American Transplant Congress abstracts