ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2016 American Transplant Congress

    Detection of Endothelial Cell Specific Molecule-1 According to Allograft Status After Kidney Transplantation.

    J.-W. Seo, S.-Y. Kim, Y.-G. Kim, Y.-H. Jeong, Y.-H. Lee, J.-Y. Moon, T.-W. Lee, C.-G. Ihm, S.-H. Lee.

    Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

    To investigate urine ESM-1(endothelial cell specific molecule-1) as well as plasma ESM-1 level from renal allograft recipients, we show whether there is the difference of…
  • 2016 American Transplant Congress

    Everolimus Abrogates C5a and TGFβ Mediated Perycite-to-Myofibroblast Transition (PMT) Inhibiting Vascular Rarefaction.

    G. Castellano, R. Franzin, A. Stasi, C. Divella, L. Gesualdo.

    Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

    Microvascular pericytes have detrimental effects on tubulo-interstitial fibrosis via PMT. However, therapeutic strategies that might interfere with this process are currently lacking. We aimed to…
  • 2016 American Transplant Congress

    Human and Mouse Treg Use Lymphotoxin for Migration Across Lymphatic Endothelium.

    C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore, MD; 2Univerity of Minnesota, Minneapolis, MN.

    Introduction: Lymphotoxin (LT) directs lymphoid organ structure, and LTβ receptor (LTβR) is involved in leukocyte migration into lymph nodes (LN) and thymocyte migration. We previously…
  • 2016 American Transplant Congress

    The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.

    M. Dieudé,1,4,5 C. Bell,2,5 J. Turgeon,1,5 D. Beillevaire,1,4,5 S. Qi,1,5 E. Boilard,3,5 P. Thibault,2,5 M.-J. Hébert.1,4,5

    1Research Centre Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Canada; 2Institute for research in immunology and cancer (IRIC), Montreal, Canada; 3Centre de Recherche du CHU de Québec, Québec, Canada; 4Université de Montréal, Montréal, Canada; 5Canadian National Transplant Research Program, Edmonton, Canada.

    Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…
  • 2016 American Transplant Congress

    Blocking MHC Class II on Human Endothelium Mitigates Acute Rejection of Vessel Allografts by Effector Memory T Cells.

    P. Abrahimi,1 L. Qin,2 W. Chang,1 A. Bothwell,1 G. Tellides,2 W. Saltzman,3 J. Pober.1

    1Immunobiology, Yale School of Medicine, New Haven, CT; 2Surgery, Yale School of Medicine, New Haven, CT; 3Biomedical Engineering, Yale University, New Haven, CT.

    Acute allograft rejection is mediated by alloreactive CD8+ T cells that differentiate into cytotoxic lymphocytes (CTL). In most rodent models, CTL differentiate from naïve CD8+…
  • 2016 American Transplant Congress

    Pathogenic Role of Anti-HLA Antibodies on Endothelial Progenitor Cell Dysfunction of Highly Sensitized Kidney Transplanted Patients.

    V. Cantaluppi,1 S. Dellepiane,2 D. Medica,2 G. Tognarelli,2 M. Quaglia,1 C. Musetti,1 A. Airoldi,1 L. Biancone.2

    1Nephrology, Dialysis and Kidney Transplantation Unit, University of Eastern Piedmont "A. Avogadro", Novara, Italy; 2Nephrology, Dialysis and Kidney Transplantation Unit, University of Torino, Torino, Italy.

    Anti-HLA antibodies (abs) bind to kidney graft endothelial cells inducing complement-mediated injury and humoral rejection. Endothelial Progenitor Cells (EPC) are bone marrow-derived precursors able to…
  • 2016 American Transplant Congress

    Sphingosine 1-Phosphate (S1P) Receptors Differentially Regulate Murine and Human CD4 T Cell Migration Across Lymphatic Endothelium.

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.

    S1P and S1PR1 are used by T cells to migrate from thymus across microvascular endothelium to the blood circulation, and across medullary lymphatic endothelium of…
  • 2016 American Transplant Congress

    A Unique In Vitro Migration Model for Leukocyte Trans-Lymphatic Endothelial Migration.

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.

    Trans-endothelial migration (TEM) is an essential process for leukocyte circulation. While much is known about lymphocyte blood to tissue migration, far less is known about…
  • 2016 American Transplant Congress

    Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.

    R. Finnegan,1 P. Zhu,1 S. Stephenson,1 K. Patel,2 S. Nadig,1,2,3 C. Atkinson.1,2,3

    1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; 2Department of Surgery, Medical University of South Carolina, Charleston, SC; 3South Carolina Investigators in Transplantation, Medical University of South Carolina, Charleston, SC.

    Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…
  • 2016 American Transplant Congress

    HLA Antibody Clonality and Epitopes Dictate Complement Activation.

    K. Thomas,1 N. Valenzuela,1 A. Mulder,2 E. Reed.1

    1Pathology and Laboratory Medicine, UCLA, Los Angeles, CA; 2Leiden University Medical Center, Leiden, Netherlands.

    Background: Alloimmunization results in production of polyclonal donor specific antibodies (DSA) against human leukocyte antigens (HLA), which mediate endothelial cell activation, leukocyte recruitment, and complement…
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