ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2018 American Transplant Congress

    Targeting Lymphotoxin Signaling in Lymphatics Regulates Immune Sensitization, Elicitation, and Resolution

    W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.

    UMB, MD.

    Background:Contact hypersensitivity (CHS) is a T cell-mediated cutaneous inflammatory response which includes three phases of priming/sensitization, elicitation, and resolution,mirroring many aspects of allogeneic responses. The…
  • 2018 American Transplant Congress

    p16INK4a Deletion in Vascular Endothelium Improves Kidney Regeneration Post Ischemia Reperfusion Injury

    A. Melk,1 A. Baisantry,1,2 S. Wang,1 F. Kubaink,1 R. Bhayadia,1 R. Schmitt.2

    1Department of Kidney, Liver & Metabolic Diseases, MHH, Hannover, Germany; 2Department of Nephrology, MHH, Hannover, Germany.

    Background: Ischemia Reperfusion injury (IRI) mediated cellular senescence in kidney allografts has been linked to a loss in regenerative potential and delayed graft function. Injured…
  • 2018 American Transplant Congress

    Endothelin A Receptor (ETaR) siRNA Ameliorates Renal Ischemia Reperfusion Injury through Upregulating Expression of eNOS in Rats

    Y. Jia, L. Li, T. Zhu.

    Shanghai Key Labratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.

    Aims: To explore the protective effect of Endothelin A Receptor (ETaR) siRNA on renal ischemia reperfusion injury and its underlying mechanism.Methods: The model of unilateral…
  • 2018 American Transplant Congress

    Novel Function of TIE2 in Immunoregulation

    C. Ghosh, T. Agur, A-.L. Mak, S. Pal, J. Wedel, B. David.

    Transplant Research Program, Boston Children's Hospital, Boston, MA.

    The immunogenicity of graft microvascular endothelial cells (ECs) has immense biological significance in the modulation of the local intragraft microenvironment. EC may either support Teffector…
  • 2018 American Transplant Congress

    Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells

    W. Hassanein,1 P. Patel,1 A. Werdsheim,1 J. Brilliant,1 E. Buckingham,1 N. Shockcor,1 C. Drachenberg,2 R. Barth,1 J. LaMattina.1

    1Surgery, University of Maryland, Baltimore, MD; 2Pathology, University of Maryland, Baltimore, MD.

    Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…
  • 2018 American Transplant Congress

    Recombinant Thrombomodulin alpha Attenuates Kidney Graft Damage after Long Cold Ischemia Time in a Rat Kidney Transplant Model

    S. Tamaki,1 K. Shinoda,1 M. Shimoda,2 S. Morita,1 H. Asanuma,1 M. Oya.1

    1Urology, Keio University School of Medicine, Tokyo, Japan; 2Pathology, Keio University School of Medicine, Tokyo, Japan.

    Objectives: Thrombomodulin (TM) extensively expresses on the endothelial cells in the steady state and is known to prevent hypercoagulation via combining with thrombin and inactivating…
  • 2018 American Transplant Congress

    Ultrastructural Changes in Lung Allografts: Endothelial Changes Correlate with Donor Specific Antibody & Antibody Mediated Rejection

    M. Alexander, A. Bentall, P. Abell Aleff, J. Scott, A. Roden.

    Mayo Clinic, Rochester, MN.

    Introduction: Antibody mediated rejection (AMR) causes lung allograft (LA) injury. Challenges with C4d interpretation & lack of specific histological criteria account for difficulty in diagnosing…
  • 2018 American Transplant Congress

    Rapamycin Impairs Human Endothelial Cell Alloimmunogenicity Independent of PD-1/PD-1 Ligand Inhibitory Signaling

    Q. Gao, V. Bendersky, A. Kirk, H. Xu.

    Department of Surgery, Duke University Medical Center, Durham, NC.

    Rapamycin prevents costimulation blockade (CoB)-resistant rejection in mice and primates, and early human data suggests a similar salutary effect. We have hypothesized that one mechanism…
  • 2018 American Transplant Congress

    Treg Regulate Distinct Lymphatic NFκB Signaling Pathways to Alter Migration and Immunity

    W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.

    UMB, MD.

    Background: Treg migration to the graft and draining lymph nodes is crucial for graft survival. Little is known about the molecular cues that regulate the…
  • 2018 American Transplant Congress

    CD40 Signaling in Proximal Tubules Regulates Fibrosis in Both Hypertension and Chronic Allograft Rejection

    V. Bletsos, J. Breidenbach, S. Haller, S. Stepkowski.

    University of Toledo College of Medicine and Life Sciences, Toledo, OH.

    Background: We explored the role of CD40 signaling in kidney proximal tubule epithelial cells on renal interstitial fibrosis (IF) in two models: hypertension; and chronic…
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