2019 American Transplant Congress
Platelets Augment Granzyme K Production By Macrophages In Antibody-mediated Rejection
Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: When antibodies bind to MHC antigens on endothelial cells a cascade of responses is initiated including exocytosis of adhesion molecules followed by attachment and…2019 American Transplant Congress
Lymphotoxin Beta Receptor Determines Lymph Node Structure for Treg Migration and Suppression of Graft Rejection
*Purpose: Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels…2019 American Transplant Congress
Intact Lymphatics Are Essential for Costimulation Blockade-Induced Lung Allograft Survival
*Purpose: Blocking lymphangiogenesis is thought to diminish immune responses to donor tissues. However, lung transplantation (Tx), which involves airway and vascular but not lymphatic anastomoses,…2019 American Transplant Congress
Serum Adipocyte Fatty Acid Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients
*Purpose: Adipocyte fatty acid-binding protein (A-FABP) is abundantly found in mature adipocytes, activated macrophages, and dendritic cells and is involved in lipid metabolism, metabolic and…2018 American Transplant Congress
Endothelial Cell Heterogeneity Governs Basal and Inducible Inflammatory Responses Relevant to Allograft Injury
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
PurposeTransplanted tissues are differentially susceptible to ischemia/reperfusion and rejection. Endothelial cells (EC) are active regulators of inflammation. But model EC may not adequately reflect the…2018 American Transplant Congress
Targeting Lymphotoxin Signaling in Lymphatics Regulates Immune Sensitization, Elicitation, and Resolution
Background:Contact hypersensitivity (CHS) is a T cell-mediated cutaneous inflammatory response which includes three phases of priming/sensitization, elicitation, and resolution,mirroring many aspects of allogeneic responses. The…2018 American Transplant Congress
p16INK4a Deletion in Vascular Endothelium Improves Kidney Regeneration Post Ischemia Reperfusion Injury
Background: Ischemia Reperfusion injury (IRI) mediated cellular senescence in kidney allografts has been linked to a loss in regenerative potential and delayed graft function. Injured…2018 American Transplant Congress
Endothelin A Receptor (ETaR) siRNA Ameliorates Renal Ischemia Reperfusion Injury through Upregulating Expression of eNOS in Rats
Aims: To explore the protective effect of Endothelin A Receptor (ETaR) siRNA on renal ischemia reperfusion injury and its underlying mechanism.Methods: The model of unilateral…2018 American Transplant Congress
Novel Function of TIE2 in Immunoregulation
Transplant Research Program, Boston Children's Hospital, Boston, MA.
The immunogenicity of graft microvascular endothelial cells (ECs) has immense biological significance in the modulation of the local intragraft microenvironment. EC may either support Teffector…2018 American Transplant Congress
Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells
1Surgery, University of Maryland, Baltimore, MD; 2Pathology, University of Maryland, Baltimore, MD.
Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…
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