Articles tagged "Endothelial activation"

2016 American Transplant Congress
Markers of Activation of Microvascular Endothelial Cells Predict a Poor Long-Term Graft Outcome in Early Renal Graft Biopsies Displaying Acute Tubular Necrosis.
Y.-C. Dubois-Xu,¹ P. Ahmadpoor,¹ A. Corchia,¹ D. Buob,² P. Galichon,¹ I. Brochériou,¹ C. Suberbielle,³ A. Hertig,¹ E. Rondeau.¹
¹INSERM UMR_S1155, INSERM, Paris, France; ²Pathology, APHP, Hoptal Tenon, Paris, France; ³HLA Institute, INSERM_S940, Paris, France.
Acute tubular necrosis (ATN), is a histopathological feature frequently seen in the early post renal transplant biopsies taken from patients with delayed graft function (DGF).…
2016 American Transplant Congress
Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR.
S. Salehi, E. Reed.
Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.
Aim: Antibody-mediated rejection (AMR) is a major issue affecting solid organ transplants, manifesting with recruitment of monocytes to the endothelium of the allograft. The purpose…
2015 American Transplant Congress
Oxidative Stress During Organ Recovery Influences Transplant Vasculopathy Development
M. Maglione,¹ G. Riede,¹ B. Cardini,¹ D. Bernhard,² B. Messner,² K. Watschinger,³ C. Steger,⁴ G. Brandacher,⁵ J. Pratschke,¹ E. Werner,³ R. Oberhuber.¹
¹Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria; ²Cardiac Surgery Research Laboratory, Department of Surgery, Vienna Medical University, Vienna, Austria; ³Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria; ⁴Institute of Pathology, Innsbruck Medical University, Innsbruck, Austria; ⁵Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Transplant vasculopathy is still a major obstacle to long-term graft survival. Pharmacological strategies aiming at preventing it are still lacking. Herein we show that the…
2015 American Transplant Congress
Serum Proteins Are Significantly Upregulated in Patients With Clinical Antibody-Mediated Rejection
A. Gareau,¹ I. Gibson,² C. Wiebe,¹ J. Ho,¹ D. Rush,¹ P. Nickerson.¹
¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Pathology, University of Manitoba, Winnipeg, MB, Canada.
Background: Antibody-mediated rejection (ABMR) is a major pathway associated with late graft loss. Although serum de novo donor-specific HLA antibodies are frequently observed in ABMR,…
2015 American Transplant Congress
Antibody-Induced Platelet Activation Increases Allograft Hyaluronan Fragmentation
H.-H. Kuo,¹ R. Fan,¹ N. Dvorina,¹ C. De La Motte,² W. Baldwin.¹
¹Immunology, Lerner Research Istitute, Cleveland, OH; ²Pathobiology, Lerner Research Institute, Cleveland, OH.
Antibodies to MHC class I antigens have been shown to activate endothelial cells to release von Willebrand factor (vWf) and P-selectin from storage granules. These…
2015 American Transplant Congress
mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia
I. Werner, A. Hernandez-Sierra, F. Guo, A. Moritz, A. Beiras-Fernandez.
Department of Thoracic and Cardiovascular Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany.
ObjectivemTOR inhibitors Everolimus and Sirolimus are currently used as maintenance immunosuppressive agents to prevent rejection of solid transplanted organs. Episodes of transplant rejection and graft…
2015 American Transplant Congress
A Specific Inhibitor of C1s, TNT003, Prevents Complement-Mediated Enhancement of Monocyte Adhesion to Endothelium in Response to HLA Antibodies
N. Valenzuela,¹ K. Thomas,¹ A. Mulder,² G. Parry,³ S. Parker,³ E. Reed.¹
¹Immunogenetics Center, UCLA, Los Angeles, CA; ²Leiden University, Leiden, Netherlands; ³True North Therapeutics, San Francisco, CA.
HLA antibody (Ab) mediated complement activation on endothelial cells (EC) is likely a critical driver of antibody-mediated inflammation. Production of complement anaphylatoxins by HLA antibodies…