ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial activation"

  • 2020 American Transplant Congress

    Activation of the ICOS/ICOS-Ligand Pathway in Antibody-Mediated Kidney Graft Rejection

    V. Cantaluppi1, G. Merlotti1, M. Quaglia1, G. Rosso1, N. Clemente1, G. Cappellano1, A. Chiocchetti1, G. Castellano2, U. Dianzani1, G. Camussi3

    1Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy, 2Nephrology, Dialysis and Kidney Transplantation Unit, University of Foggia, Foggia, Italy, 3Department of Medical Sciences, University of Torino, Torino, Italy

    *Purpose: The costimulatory pathway ICOS/ICOS-Ligand may represent a new therapeutic target in antibody-mediated rejection (ABMR), the major cause of long term kidney graft failure. The…
  • 2020 American Transplant Congress

    Mitochondrion-Endothelial Interaction Generates Danger Signal in Promoting Costimulation-Resistant T Cell-Mediated Allograft Rejection

    S. Li1, M. Song1, Q. Li2, A. Kirk1, H. Xu1

    1Surgery, Duke University, Durham, NC, 2Immunology, Duke University, Durham, NC

    *Purpose: Endothelial cells (ECs) play a critical role in allorecognition, presentation, and costimulation for initiation of alloimmune rejection. The objective of this study was to…
  • 2020 American Transplant Congress

    PD-L1 Signals Lymphatic Endothelium for Treg Migration

    W. Piao1, L. Li1, K. Hippen2, Y. Zhang2, V. Saxena3, Y. Xiong1, C. Paluskievicz1, M. WillsonShirkey1, B. Blazar2, L. Riella4, J. Bromberg5

    1Surgery, U of Maryland, Baltimore, MD, 2Pediatrics, U of Minnesota, Minneapolis, MN, 3U of Maryland, Baltimore, MD, 4Transplantation Research Center, Harvard U, Boston, MA, 5Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD

    *Purpose: Regulatory T cell (Treg) migration is important for tolerance, although the molecules that regulate Treg entry to lymphatics are poorly understood. Lymphatic endothelial cells…
  • 2020 American Transplant Congress

    The Effect of Human Thrombomodulin on Thrombotic Complications in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation

    C. E. Goerlich1, A. Singh1, D. Kaczorowski1, M. Abdullah1, B. Lewis1, I. Tatarov1, A. Hershfeld1, T. Zhang1, P. Odonkor1, E. Strauss1, B. Williams1, D. Ayares2, M. Mohiuddin1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor, Blacksburg, VA

    *Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
  • 2020 American Transplant Congress

    Vesicle-Associated Tweak is Increased During Acute Cellular Rejection and Contributes to Endothelial Inflammation

    O. Gidlof, J. Sadrian, M. Grossi, S. Alcevska, J. Lundgren, G. Rådegran, G. Smith

    Cardiology, Lund University, Lund, Sweden

    *Purpose: Extracellular vesicles (EVs) are released from immune cells upon activation and play direct roles in allograft tolerance and rejection, in part through delivery of…
  • 2020 American Transplant Congress

    Ex Vivo Isolated Human Vessel Perfusion System for the Design and Assessment of Nanomedicines Targeted to the Endothelium

    L. G. Bracaglia1, T. Lysyy2, L. Qin2, C. Albert1, J. S. Pober2, G. Tellides2, W. M. Saltzman1, G. T. Tietjen2

    1Yale University, New Haven, CT, 2Yale School of Medicine, New Haven, CT

    *Purpose: In solid organ transplantation the host immune system acts to reject the graft. This process is facilitated at the endothelial surface, where inflamed donor…
  • 2020 American Transplant Congress

    Novel Technique to Analyze Blood-Endothelial Cell Interactions Under Flow Conditions

    M. R. Connolly1, K. Petitpas1, L. Burdorf1, B. Cerel1, C. Laird2, D. Harris2, A. Azimzadeh1, R. N. Pierson III1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2University of Maryland, Baltimore, Baltimore, MD

    *Purpose: The Bioflux system has been used to study platelet-driven thrombosis and leukocyte adhesion. Typically, whole blood is stained with calcein (green) to evaluate platelet…
  • 2020 American Transplant Congress

    Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation

    A. S. Naik, R. Menon, E. Otto, C. C. Berthier, E. Farkash, S. P. Norman, M. Kretzler

    University of Michigan, Ann Arbor, MI

    *Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…
  • 2019 American Transplant Congress

    Clazakizumab Acts on Endothelial Cells to Limit Antibody Mediated Damage

    J. Lion1, K. Poussin1, E. Chong2, D. Glotz3, N. A. Mooney1

    1Alloimmunité-Autoimmunité-Transplantation, INSERM, Paris, France, 2Vitaeris, Vancouver, BC, Canada, 3Nephrology and Transplantation, Hôpital Saint Louis, Paris, France

    *Purpose: Human microvascular endothelial cell expression of HLA class II antigens is strongly increased, both in vitro and in vivo, under inflammatory conditions. HLA class…
  • 2019 American Transplant Congress

    ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy

    D. Jane-wit1, C. Fang1, L. Liu1, L. Qin1, G. Guangxin Li1, P. Nigrovic2, G. Tellides3, J. Pober4

    1Dept of Cardiology, Yale University School of Medicine, New Haven, CT, 2Dept of Rheumatology, Immunology, and Allergy, Harvard University, Boston, MA, 3Dept of Surgery, Yale University School of Medicine, New Haven, CT, 4Dept of Immunobiology, Yale University School of Medicine, New Haven, CT

    *Purpose: Complement promotes vascular inflammation in transplant organ rejection, a process leading to cardiac allograft vasculopathy. In this study, we identify a new Rab5 effector…
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