ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Articles tagged "Endothelial activation"

  • 2020 American Transplant Congress

    Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation

    A. S. Naik, R. Menon, E. Otto, C. C. Berthier, E. Farkash, S. P. Norman, M. Kretzler

    University of Michigan, Ann Arbor, MI

    *Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…
  • 2020 American Transplant Congress

    Extracellular Vesicles Mediate Endothelial to Mesenchymal Transition and Tubular Senescence in Renal Antibody- Mediated Rejection by Inducing Complement Activation

    G. Castellano, R. Franzin, A. Stasi, C. Divella, G. Merlotti, M. Quaglia, F. Sallustio, G. Stallone, V. Cantaluppi, L. Gesualdo

    Emergency and Organ Transplantation, University of Bari, Bari, Italy

    *Purpose: EVs (Extracellular vesicles), circulating microparticles able to mediate cell-to cell communication, are emerging as pivotal in different kidney diseases. Renal Antibody-Mediated Rejection (AMR) is…
  • 2020 American Transplant Congress

    Activation of the ICOS/ICOS-Ligand Pathway in Antibody-Mediated Kidney Graft Rejection

    V. Cantaluppi1, G. Merlotti1, M. Quaglia1, G. Rosso1, N. Clemente1, G. Cappellano1, A. Chiocchetti1, G. Castellano2, U. Dianzani1, G. Camussi3

    1Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy, 2Nephrology, Dialysis and Kidney Transplantation Unit, University of Foggia, Foggia, Italy, 3Department of Medical Sciences, University of Torino, Torino, Italy

    *Purpose: The costimulatory pathway ICOS/ICOS-Ligand may represent a new therapeutic target in antibody-mediated rejection (ABMR), the major cause of long term kidney graft failure. The…
  • 2020 American Transplant Congress

    Mitochondrion-Endothelial Interaction Generates Danger Signal in Promoting Costimulation-Resistant T Cell-Mediated Allograft Rejection

    S. Li1, M. Song1, Q. Li2, A. Kirk1, H. Xu1

    1Surgery, Duke University, Durham, NC, 2Immunology, Duke University, Durham, NC

    *Purpose: Endothelial cells (ECs) play a critical role in allorecognition, presentation, and costimulation for initiation of alloimmune rejection. The objective of this study was to…
  • 2020 American Transplant Congress

    PD-L1 Signals Lymphatic Endothelium for Treg Migration

    W. Piao1, L. Li1, K. Hippen2, Y. Zhang2, V. Saxena3, Y. Xiong1, C. Paluskievicz1, M. WillsonShirkey1, B. Blazar2, L. Riella4, J. Bromberg5

    1Surgery, U of Maryland, Baltimore, MD, 2Pediatrics, U of Minnesota, Minneapolis, MN, 3U of Maryland, Baltimore, MD, 4Transplantation Research Center, Harvard U, Boston, MA, 5Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD

    *Purpose: Regulatory T cell (Treg) migration is important for tolerance, although the molecules that regulate Treg entry to lymphatics are poorly understood. Lymphatic endothelial cells…
  • 2020 American Transplant Congress

    The Effect of Human Thrombomodulin on Thrombotic Complications in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation

    C. E. Goerlich1, A. Singh1, D. Kaczorowski1, M. Abdullah1, B. Lewis1, I. Tatarov1, A. Hershfeld1, T. Zhang1, P. Odonkor1, E. Strauss1, B. Williams1, D. Ayares2, M. Mohiuddin1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor, Blacksburg, VA

    *Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
  • 2020 American Transplant Congress

    Vesicle-Associated Tweak is Increased During Acute Cellular Rejection and Contributes to Endothelial Inflammation

    O. Gidlof, J. Sadrian, M. Grossi, S. Alcevska, J. Lundgren, G. Rådegran, G. Smith

    Cardiology, Lund University, Lund, Sweden

    *Purpose: Extracellular vesicles (EVs) are released from immune cells upon activation and play direct roles in allograft tolerance and rejection, in part through delivery of…
  • 2020 American Transplant Congress

    Ex Vivo Isolated Human Vessel Perfusion System for the Design and Assessment of Nanomedicines Targeted to the Endothelium

    L. G. Bracaglia1, T. Lysyy2, L. Qin2, C. Albert1, J. S. Pober2, G. Tellides2, W. M. Saltzman1, G. T. Tietjen2

    1Yale University, New Haven, CT, 2Yale School of Medicine, New Haven, CT

    *Purpose: In solid organ transplantation the host immune system acts to reject the graft. This process is facilitated at the endothelial surface, where inflamed donor…
  • 2019 American Transplant Congress

    ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy

    D. Jane-wit1, C. Fang1, L. Liu1, L. Qin1, G. Guangxin Li1, P. Nigrovic2, G. Tellides3, J. Pober4

    1Dept of Cardiology, Yale University School of Medicine, New Haven, CT, 2Dept of Rheumatology, Immunology, and Allergy, Harvard University, Boston, MA, 3Dept of Surgery, Yale University School of Medicine, New Haven, CT, 4Dept of Immunobiology, Yale University School of Medicine, New Haven, CT

    *Purpose: Complement promotes vascular inflammation in transplant organ rejection, a process leading to cardiac allograft vasculopathy. In this study, we identify a new Rab5 effector…
  • 2019 American Transplant Congress

    Novel Activation Responses by Endothelial Cells within the Pro-Tolerogenic Intragraft Microenvironment

    J. Wedel1, K. Liu1, P. T. Sage2, C. V. Carman3, P. Bobrowicz4, S. Kong5, B. McLaughlin4, D. M. Briscoe1

    1Transplant Research Program, Boston Children's Hospital, Boston, MA, 2Transplant Research Center, Brigham and Woman Hospital, Boston, MA, 3Harvard T.H. Chan School of Public Health, Boston, MA, 4Compass Therapeutics, Cambridge, MA, 5Computational Health Informatics Program, Boston Children's Hospital, Boston, MA

    *Purpose: Current paradigms indicate that endothelial cells (EC) within allografts participate in the initiation and progression of allograft rejection. However, little is known about their…
  • « Previous Page
  • 1
  • 2
  • 3
  • 4
  • 5
  • Next Page »

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences