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Articles tagged "Drug interaction"

  • 2021 American Transplant Congress

    Are Tacrolimus Concentrations Reduced with Direct-acting Antiviral Administration in Transplant Recipients?

    K. Huang, K. Farrow, M. Christian

    Pharmacy, Penn State Health Hershey Medical Center, Hershey, PA

    *Purpose: To evaluate the effects of direct-acting antivirals (DAAs) on tacrolimus trough concentrations and clinical outcome and to assess the need for a priori dose…
  • 2021 American Transplant Congress

    Iatrogenic Sodium Exposure in Hospitalized Patients with Liver Disease

    P. Klem1, R. Mbangu Kot Mbau2, B. Crowther1, V. Lewis1, S. Lin1, E. Patrick3, A. Nadrash1, K. Schoeppler1, I. Kim1

    1Pharmacy, University of Colorado Hospital, Aurora, CO, 2Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, 3Transplant Services, University of Colorado Hospital, Aurora, CO

    *Purpose: Numerous medications administered in the hospital setting may contain hidden/additional amounts of sodium in the drug itself and via intravenous (IV) diluents or admixtures.…
  • 2021 American Transplant Congress

    Reduction in Medication Errors at Discharge in the Transplant Population via Use of Novel Pharmacist / Nursing Dual Check System

    M. Norris, S. Witek, C. Whritenour, K. Sigafus, C. Chiang, C. Sammons, D. Naveiro, A. Paredes, E. Perez-Ngai, M. Kaminski, R. Westmoreland, G. Malat

    Hospital of the University of Pennsylvania, Philadelphia, PA

    *Purpose: Medication errors are of great concern due to the risk for patient and allograft injury. The aim of this study was to evaluate the…
  • 2020 American Transplant Congress

    Largest Experience of Safety, and Efficacy of Patiromer in Solid Organ Transplants (SOT)

    P. Singh1, H. Winters2, T. E. Pesavento1, K. Schnelle2

    1Transplant Nephrology, Ohio State University, Columbus, OH, 2Transplant Pharmacy, Ohio State University, Columbus, OH

    *Purpose: Hyperkalemia, a potentially life‐threatening electrolyte abnormality, is commonly seen SOT. The predisposing factors are renal-dysfunction, and medications (CNI, TMP-SMX, ACEI, and ARBs). Patiromer, a…
  • 2020 American Transplant Congress

    Role of Tacrolimus Dose Adjustment at Discontinuation of Fluconazole in Liver Transplant

    J. Yau, H. Morris

    University of Virginia Health System, Charlottesville, VA

    *Purpose: The purpose of this study was to characterize the effects of fluconazole (fluc) discontinuation on tacrolimus (tac) levels and the role of prophylactic dose…
  • 2020 American Transplant Congress

    Lack of Drug-Drug Interaction between Maribavir and Voriconazole

    I. H. Song1, K. Ilic2, J. Wu3

    1Quantitative Clinical Pharmacology, Shire, a Takeda Company, Lexington, MA, 2Rare Disease TAU, Shire, a Takeda Company, Lexington, MA, 3Biostat, Shire, a Takeda Company, Lexington, MA

    *Purpose: Maribavir is being evaluated in Phase 3 trials for the treatment of cytomegalovirus infections in transplant recipients. These patients often take numerous concomitant medications,…
  • 2020 American Transplant Congress

    Evaluation of the Use of Sublingual Tacrolimus in the Inpatient Setting

    K. Szempruch1, L. Kemp1, A. Barber1, S. Mason1, G. Offei-Nkansah1, D. Gerber2, P. Owen1

    1Pharmacy, UNC Medical Center, Chapel Hill, NC, 2Surgery-Transplant, UNC Medical Center, Chapel Hill, NC

    *Purpose: To determine the efficacy and safety of sublingual (SL) tacrolimus (TAC) administration.*Methods: A single-center, retrospective study was performed on solid organ transplant recipients who…
  • 2020 American Transplant Congress

    Evaluation of SUBA-Itraconazole Use in Lung Transplant Recipients

    J. G. Youssef1, C. Ahmed1, B. J. Pierce2, C. Pham2, F. Ye1, K. Tatum1, S. Yau1, A. Goodarzi1, H. J. Huang1

    1Department of Medicine, Houston Methodist Hospital, Houston, TX, 2Department of Pharmacy, Houston Methodist Hospital, Houston, TX

    *Purpose: Itraconazole (IT) is commonly used after lung transplant for fungal prophylaxis, particularly in those with a history of skin cancer, concern for Histoplasmosis infection,…
  • 2020 American Transplant Congress

    Glecaprevir-Pibrentasvir Effect on Tacrolimus Troughs in Abdominal Transplant Recipients

    M. Chunduru, K. Schnelle, H. Winters, O. Witkowsky, L. Von Stein

    The Ohio State Wexner Medical Center, Columbus, OH

    *Purpose: Glecaprevir-pibrentasvir (GP) is one of several pangenotypic therapies available for the treatment of hepatitis C. Historical use of ritonavir based hepatitis C therapies increased…
  • 2020 American Transplant Congress

    Sodium Zirconium Cyclosilicate Use in Solid Organ Transplant Recipients and its Effect on Potassium and Immunosuppression

    R. Winstead, M. Demehin, I. Yakubu, C. Song, A. Brown, M. Levy, L. Kamal, G. Gupta

    VCU Health, Richmond, VA

    *Purpose: Transplant recipients often suffer from hyperkalemia which can limit pharmacotherapy. The cause of hyperkalemia is often multifactorial including kidney dysfunction, calcineurin inhibitor use, and…
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