Articles tagged "Drug interaction"

2021 American Transplant Congress
Clazakizumab (clz, Anti-il-6 Antibody) Treatment Affects Il-6/il-6r Signaling by Increasing Soluble Gp130 (sgp130) in Hla-sensitized Kidney Transplant Patients (hs Ktx Pts) Treated for Chronic Antibody-mediated Rejection (cabmr)
B. Shin, S. Ge, A. Jimenez, N. Ammerman, A. Vo, R. Zhang, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Cerritos, CA
*Purpose: IL-6 is a pro-inflammatory cytokine responsible for chronic vascular inflammation and a promising target for cABMR modulation. IL-6/sIL-6R complex initiates more pathogenic trans-signaling pathways…
2021 American Transplant Congress
Quantifying the Interaction Between Posaconazole and Tacrolimus in Liver Transplant Recipients: A Practical Approach
B. Lane¹, U. Kaszubski¹, A. Freeman¹, B. Wise¹, L. Hutchinson¹, M. Janusek¹, G. Therapondos², H. Bohorquez³, S. Anders¹
¹Pharmacy, Ochsner Medical Center, New Orleans, LA, ²Hepatology, Ochsner Medical Center, New Orleans, LA, ³Transplant Surgery, Ochsner Medical Center, New Orleans, LA
*Purpose: The interaction between tacrolimus (FK) and posaconazole (POSA) is well documented, however the extent of this interaction and the practical management has yet to…
2021 American Transplant Congress
Implementation of a High-risk Medication Report for Waitlisted Liver Transplant Candidates
M. M. Eiting¹, H. Yeh², M. Cote¹, S. Shao¹, A. B. Scherrer², L. Dageforde², N. Elias², C. Rogers Marks¹
¹Pharmacy, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA
*Purpose: Use of high-risk medications (HRMs) at the time of liver transplant may lead to delays in surgery or peri-operative complications (bleeding, drug-drug interactions (DDI),…
2020 American Transplant Congress
Lack of Drug-Drug Interaction between Maribavir and Voriconazole
I. H. Song¹, K. Ilic², J. Wu³
¹Quantitative Clinical Pharmacology, Shire, a Takeda Company, Lexington, MA, ²Rare Disease TAU, Shire, a Takeda Company, Lexington, MA, ³Biostat, Shire, a Takeda Company, Lexington, MA
*Purpose: Maribavir is being evaluated in Phase 3 trials for the treatment of cytomegalovirus infections in transplant recipients. These patients often take numerous concomitant medications,…
2020 American Transplant Congress
Evaluation of the Use of Sublingual Tacrolimus in the Inpatient Setting
K. Szempruch¹, L. Kemp¹, A. Barber¹, S. Mason¹, G. Offei-Nkansah¹, D. Gerber², P. Owen¹
¹Pharmacy, UNC Medical Center, Chapel Hill, NC, ²Surgery-Transplant, UNC Medical Center, Chapel Hill, NC
*Purpose: To determine the efficacy and safety of sublingual (SL) tacrolimus (TAC) administration.*Methods: A single-center, retrospective study was performed on solid organ transplant recipients who…
2020 American Transplant Congress
Evaluation of SUBA-Itraconazole Use in Lung Transplant Recipients
J. G. Youssef¹, C. Ahmed¹, B. J. Pierce², C. Pham², F. Ye¹, K. Tatum¹, S. Yau¹, A. Goodarzi¹, H. J. Huang¹
¹Department of Medicine, Houston Methodist Hospital, Houston, TX, ²Department of Pharmacy, Houston Methodist Hospital, Houston, TX
*Purpose: Itraconazole (IT) is commonly used after lung transplant for fungal prophylaxis, particularly in those with a history of skin cancer, concern for Histoplasmosis infection,…
2020 American Transplant Congress
Glecaprevir-Pibrentasvir Effect on Tacrolimus Troughs in Abdominal Transplant Recipients
M. Chunduru, K. Schnelle, H. Winters, O. Witkowsky, L. Von Stein
The Ohio State Wexner Medical Center, Columbus, OH
*Purpose: Glecaprevir-pibrentasvir (GP) is one of several pangenotypic therapies available for the treatment of hepatitis C. Historical use of ritonavir based hepatitis C therapies increased…
2020 American Transplant Congress
Sodium Zirconium Cyclosilicate Use in Solid Organ Transplant Recipients and its Effect on Potassium and Immunosuppression
R. Winstead, M. Demehin, I. Yakubu, C. Song, A. Brown, M. Levy, L. Kamal, G. Gupta
VCU Health, Richmond, VA
*Purpose: Transplant recipients often suffer from hyperkalemia which can limit pharmacotherapy. The cause of hyperkalemia is often multifactorial including kidney dysfunction, calcineurin inhibitor use, and…
2020 American Transplant Congress
Zoledronate Induced AKI with Nephrotic Range Proteinuria in a Transplant Kidney
S. Reddy, H. Khamash
Nephrology, Mayo Clinic, Phoenix, AZ
*Purpose: An unusual presentation of acute kidney injury with nephrotic range proteinuria following zoledronate in a normal functioning transplant kidney.*Methods: 61-year-old lady with history of…
2020 American Transplant Congress
Largest Experience of Safety, and Efficacy of Patiromer in Solid Organ Transplants (SOT)
P. Singh¹, H. Winters², T. E. Pesavento¹, K. Schnelle²
¹Transplant Nephrology, Ohio State University, Columbus, OH, ²Transplant Pharmacy, Ohio State University, Columbus, OH
*Purpose: Hyperkalemia, a potentially life‐threatening electrolyte abnormality, is commonly seen SOT. The predisposing factors are renal-dysfunction, and medications (CNI, TMP-SMX, ACEI, and ARBs). Patiromer, a…