ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Dosage"

  • 2022 American Transplant Congress

    Reduction of Rabbit Anti-Thymocyte Globulin Dosing for Induction of Kidney Transplant During the COVID-19 Pandemic

    C. Burrelli1, S. Gundling1, D. Ecabert1, R. Powell1, A. Padiyar1, K. Andreoni1, K. Chavin2, A. Bixby1

    1University Hospitals Cleveland Medical Center, Cleveland, OH, 2University Hospitals Cleveland Medical Center / Case Western Reserve, Cleveland, OH

    *Purpose: Rabbit anti-thymocyte globulin (rATG) is a polyclonal antibody utilized for induction immunosuppression in high immunologic risk kidney transplant recipients. However, the optimal total dose…
  • 2022 American Transplant Congress

    Real-Life Tacrolimus Levels Are Associated with Biopsy-Proven Acute Rejection After the First Year Post-Kidney Transplantation

    S. Meziyerh, T. van Gelder, D. van der Helm, P. J. van der Boog, J. W. de Fijter, D. J. Moes, A. P. de Vries

    LUMC, Leiden, Netherlands

    *Purpose: Evidence to recommend specific target concentrations for immunosuppression beyond the first year of kidney transplantation (KT) is limited. We correlated real-life exposure data of…
  • 2022 American Transplant Congress

    Conversion of Tacrolimus Immediate Release to LCP Tacrolimus in Obese Kidney Transplant Recipients

    J. Newman, N. Patel, S. Patel, T. Sprague, E. Andrade, N. Rao, F. Bartlett, D. DuBay, V. Rohan, M. Casey, D. Taber

    MUSC, Charleston, SC

    *Purpose: Data describing the safety, efficacy and conversion ratio of tacrolimus immediate release (IR) to LCP-tacrolimus (LCP) in obese patients (BMI > 30) is lacking.…
  • 2022 American Transplant Congress

    Artificial Intelligence Based Dosing of Tacrolimus in Liver Transplantation: Prospective, Randomized Phase 2 Trial

    A. Zarrinpar1, C. Ho2, C. Warren1, J. Khong2, M. Lee2, S. Duarte1, K. Andreoni1, M. Johnson1, N. Battula3, D. McKimmy1, T. Beduschi1

    1Surgery, University of Florida, Gainesville, FL, 2Mechanical and Aerospace Engineering, University of California, Los Angeles, CA, 3Surgery, University of Oklahoma, Oklahoma City, OK

    *Purpose: Inter- and intra-individual variability in calcineurin dose requirements necessitates empirical clinician-titrated dosing that frequently results in deviation from target ranges, particularly during the critical…
  • 2022 American Transplant Congress

    Use of Dd-cfdna to Guide Tapering of Immunosuppression Therapy in Kidney Transplant Recipients

    G. Osuchukwu1, A. Trevino1, L. Beretich2, S. McCormick2, N. Kaur2, R. White2, P. Gauthier2

    1Victoria Kidney and Dialysis Associates, Victoria, TX, 2Natera, Inc., Austin, TX

    *Purpose: Continuous administration of immunosuppressive therapy (IST) is required to avoid allograft rejection in transplant recipients. However, these therapeutic interventions can lead to significant side…
  • 2022 American Transplant Congress

    Incidence of Dapsone-Induced Methemoglobinemia in Solid Organ Transplant Recipients

    D. Quan1, R. Gordon1, J. Lee1, D. Khoshabafard2, A. Han1

    1Pharmacy, UCSF Medical Center, San Francisco, CA, 2Clinical Phamacy, UCSF School of Pharmacy, San Francisco, CA

    *Purpose: The purpose of this study was to determine the incidence of dapsone-induced methemoglobinemia in solid organ transplant recipients.*Methods: This was a single-center retrospective cohort…
  • 2022 American Transplant Congress

    Safety and Efficacy of Darbepoetin Alfa Dosing Strategies in Renal Transplant Recipients

    J. A. Solis, A. Dao, T. Sam, T. Ma, A. F. Yango, B. V. Fischbach, N. Wilson

    Baylor University Medical Center, Dallas, TX

    *Purpose: Post-transplant anemia (PTA) is a common phenomenon in renal transplant recipients (RTR). There are currently no consensus guidelines for PTA, however patients are commonly…
  • 2022 American Transplant Congress

    Kidney Transplant Recipients with Diabetic Mellitus Demand Larger Doses of Mycophenolate Mofetil

    D. Takamoto, H. Sasaki, S. Harada, Y. Takada, H. Harada, T. Tsujimoto

    Kidney transplant surgery and Urology, Sapporo City General Hospital, Sapporo, Japan

    *Purpose: To monitor blood concentration of immunosuppressants, therapeutic drug monitoring (TDM) is required at any point after kidney transplantation (KT) to prevent kidney graft from…
  • 2022 American Transplant Congress

    The Role of Gut Microbiota in Tacrolimus Blood Level Fluctuation, Time in Therapeutic Range and AlloSure Donor Derived Cell-Free DNA, Controlling for CYP3A5

    M. Nayebpour1, N. Koizumi1, J. Melancon2, M. Hasan2

    1George Mason University, Arlington, VA, 2George Washington University Hospital, Washington, DC

    *Purpose: High tacrolimus variability (TV), low time in therapeutic range (TTR) and high percentage of donor derived cell-free DNA (dd-cfDNA) are associated with acute kidney…
  • 2022 American Transplant Congress

    Impact of African American Race on Lcp-Tac Dosing and Clinical Outcomes

    T. Sprague, F. Bartlett, J. Newman, S. Patel, N. Rao, E. Andrande, V. Rohan, D. Dubay, M. Casey, D. Taber

    Medical University of South Carolina, Charleston, SC

    *Purpose: The goal of this study was to assess the impact of African American (AA) race on the conversion ratio from Tac-IR to LCP-Tac, while…
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