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Articles tagged "Cytomeglovirus"

  • 2018 American Transplant Congress

    The TRANSFORM Study: Infection Outcomes with Everolimus Plus Reduced Calcineurin Inhibitor and Mycophenolate Plus Standard Calcineurin Inhibitor Regimens in De Novo Kidney Transplant Recipients

    F. Vincenti, J. Cruzado, S. Mulgaonkar, V. Garcia, D. Kuypers, M. Buchler, F. Citterio, U. Huynh-Do, W-.L. Luo, P. Bernhardt, C. Sommerer.

    TRANSFORM Study Group, Novartis Pharma AG, Basel, Switzerland.

    Purpose: Post-transplant (Tx) bacterial and viral infections are known to affect graft and patient survival. Accumulating evidence supports the protective effect of everolimus (EVR) against…
  • 2018 American Transplant Congress

    Primary Cytomegalovirus Infection in Seronegative Kidney Transplant Patients is Associated with Prolonged Cold Ischemic Time of Seropositive Donor Organs

    C. Falk,1,7 F. Schlott,2,7 K. Katsrintaki,1,7 D. Steubl,3 W. Puppe,4 C. Blume,5 H. Haller,6 L. Renders,3 U. Heemann,3 D. Busch,2 M. Neuenhahn.2,7

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany; 3Department of Nephrology, Technical University Munich, Munich, Germany; 4Institute of Virology, Hannover Medical School, Hannover, Germany; 5Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany; 6Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; 7DZIF TTU-IICH, DZIF, Hannover / Munich, Germany.

    Introduction: Human Cytomegalovirus (CMV) infection is still a major risk factor for immunocompromised patients, e.g. kidney recipients. Based on the CMV serostatus of donor (D)…
  • 2018 American Transplant Congress

    Clinical Utility of CMV-Specific CD8+ T-Cell Immune Competence Score in Lung and Heart-Lung Transplant Recipients at Risk of Cytomegalovirus Infection

    A. Meesing,1 R. Abraham,2 R. Razonable.1

    1Division of Infectious Diseases, Mayo Clinic, Rochester, MN; 2Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

    Introduction: Cytomegalovirus (CMV) is a common infection that causes significant morbidity among lung and heart-lung (LHL) transplant recipients. We determined the clinical utility of global…
  • 2018 American Transplant Congress

    Cytomegalovirus (CMV) Infection in Small Intestinal and Multivisceral Transplant Recipients: The Role of Donor Selection on CMV Incidence and Outcomes

    H. Grewal, M. Czech, C. Matsumoto, M. Natarajan, J. Fraker, W. Fan, J. Timpone.

    Medstar Georgetown University Hospital, Washington DC.

    Introduction: CMV infection remains an important cause of morbidity, allograft enteritis, and allograft loss in small intestinal (SIT) and multivisceral transplant (MVT) recipients. As the…
  • 2018 American Transplant Congress

    Standard- versus Low-Dose Valganciclovir for Cytomegalovirus Prophylaxis in Intermediate-Risk Kidney Transplant Recipients

    N. Wilson, N. Sulejmani, A. Jantz, A. Patel, B. Summers.

    Henry Ford Hospital, Detroit, MI.

    Background: Although guidelines recommend valganciclovir (VGC) 900 mg daily for cytomegalovirus (CMV) prophylaxis in solid organ transplant patients, multiple centers have reported clinical success, reduced…
  • 2018 American Transplant Congress

    Identifying Specificity Groups in the CMV IE-1 T Cell Receptor Repertoire

    M. Lucia,1 F. Rubelt,2 S. Luque,3 S. Krams,1 C. Esquivel,1 O. Bestard,3 O. Martinez.1

    1Department of Surgery, Stanford University, Palo Alto; 2Institute for Immunity, Transplantation and Infection, Stanford University, Palo Alto; 3Experimental Nephrology, IDIBELL, Barcelona, Catalonia, Spain.

    Cytomegalovirus (CMV) continues to be a major problem for organ transplant recipients. T cells specific to the CMV antigens immediate-early (IE-1) and pp65 CMV govern…
  • 2018 American Transplant Congress

    Th17 and NK Responses Are Differentially Induced in Renal Allografts According to Recipient Murine Cytomegalovirus Dose and Strain

    M. Shimamura,1 M. Li,2 S. Boddeda,1 B. Chen,2 Q. Zeng,1 T. Schoeb,2 V. Velazquez.1

    1Center for Vaccines and Immunity and Dept. of Pediatric Infectious Diseases, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH; 2Depts. of Pediatric Infectious Diseases, Pathology, and Genetics, University of Alabama at Birmingham, Birmingham, AL.

    Purpose: To study the impact of cytomegalovirus (CMV) recipient positive (R+) serostatus upon renal allograft injury, murine CMV (MCMV) D+/R+ kidney transplants using recipients infected…
  • 2018 American Transplant Congress

    Recovery of Wild-Type Genotype after Documented Ganciclovir-Resistance in Transplant Recipients with Recurrent CMV Viremia

    J. Fose, M. Jorgenson, Z. Degrave, R. Redfield, J. Smith, D. Mandelbrot.

    University of Wisconsin Hospital, Madison; University of Wisconsin School of Medicine and Public Health, Madison.

    Purpose: Ganciclovir-resistant cytomegalovirus (GR-CMV) is serious complication after transplantation. Recurrence after primary GR-CMV infection is common, with literature defined rates of approximately 20-30%. It is…
  • 2018 American Transplant Congress

    Evaluation of the Use of Oral Valganciclovir for the Treatment of Cytomegalovirus Infections in Pediatric Intestinal Transplant Recipients: A Single Center Review

    M. Henry, M. Vacha, M. Keck, D. Florescu.

    Nebraska Medicine, Omaha, NE.

    Purpose: To evaluate the safety and efficacy of oral valganciclovir in treating cytomegalovirus (CMV) infections in pediatric intestinal transplant recipients (pITR).Methods: This retrospective review included…
  • 2018 American Transplant Congress

    Alveolar Macrophages Derived from MCMV Latently Infected Donors Drives the Viral Reactivation and Dissemination Following the Orthotopic Left Lung Transplantation in Mice

    S. Han, Z. Zheng, M. He, J-.J. Wang, S. Yan, M. Abecassis, Z. Zhang.

    Comprehensive Transplant Center and Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Background: The incidence of cytomegalovirus (CMV) disease is higher in lung transplants, than in other SOT recipients, especially in high-risk D+/R- recipients. Using a murine…
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