2021 American Transplant Congress
Kidney Transplant Outcomes Stratified by Age with a Calcineurin and Steroid Free Regimen
1Pharmacy, Duke University Hospital, Durham, NC, 2Nephrology, Duke University Hospital, Durham, NC
*Purpose: To evaluate the impact of an alemtuzumab, belatacept, and sirolimus based regimen on renal function stratified by age in kidney transplant (KT) patients.*Methods: This…2021 American Transplant Congress
Life-supporting Multi-gene Cardiac Xenografts From Swine Demonstrate Survival >8 Months and Preclinical Efficacy for Human Clinical Trials
*Purpose: Cardiac xenotransplantation has been proposed to bridge the gap in organ shortage for those in end-stage heart failure without the opportunity to receive a…2020 American Transplant Congress
Three Year Post Co-Stimulation Blocking Agent (Belatacept) Switch Outcomes of Kidney Transplant Patients Diagnosed with Post-Transplant Thrombotic Microangiopathy
*Purpose: Thrombotic microangiopathy (TMA) can happen after kidney transplant. It may occur de novo or as a recurrent disease. De novo is usually associated with…2020 American Transplant Congress
Belatacept Removal by Plasmapheresis: Kinetics, Dose Adjustments and Clinical Recommendations
*Purpose: Belatacept (BELA), a protein immunosuppressant, has limited available pharmacokinetic (PK) data. Available PK data, limited to product development analyses, shows moderate intrapatient variability with…2020 American Transplant Congress
Human Live Donor Liver Transplantation is Associated with Pd-l1 Expression on Donor-Exosome-Acquiring Host Dendritic Cells
Surgery- Transplantation, University of Wisconsin-Madison, Madison, WI
*Purpose: Liver transplantation (LTx) has been associated with the phenomenon of “cross-dressing” of recipient dendritic cells (DCs) by donor exosome-derived MHC antigens, and acquisition of…2020 American Transplant Congress
IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…2020 American Transplant Congress
Outcomes and Experience with Belatacept in Pediatric Kidney Transplantation
1Emory University, Atlanta, GA, 2Children's Healthcare of Atlanta, Atlanta, GA
*Purpose: Belatacept is a selective co-stimulation blocker used in adult renal transplantation and has shown improvement in glomerular filtration rate (GFR) compared to calcineurin inhibitors…2020 American Transplant Congress
CD11b is a Novel Alternate Receptor for CD154 During Alloimmunity
*Purpose: For decades, blockade of CD40-CD154 has been shown to be a highly effective means of inhibiting alloreactive T cell responses and inducing long-term graft…2020 American Transplant Congress
Post-Transplantation Lymph Node Fibrosis: Significant Implications in Transplant Tolerance
1Brigham and Women's Hospital, Boston, MA, 2University of Maryland School of Medicine, Boston, MA
*Purpose: Lymph nodes (LNs) have been regarded as primary activation sites for alloimmunity following transplantation, but our group has revealed an additional dimension to their…2020 American Transplant Congress
CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus
*Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…
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