ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Calcineurin"

  • 2017 American Transplant Congress

    Systemic Meta-Analysis: Is Early Conversion to mTOR Inhibitors Represent a Suitable Choice in Renal Transplant Recipients?

    K. Jayant,1 I. Reccia,2 J. Walton,1 A. Sharma,3 A. Halawa.1

    1Faculty of Health and Sciences, Institute of Learning and Teaching, University of Liverpool, Liverpool, United Kingdom; 2Department of Hepato-Pancreato-Biliary Surgery (HPB), Hammersmith Hospital, Imperial College, London, United Kingdom; 3Sheffield Teaching Hospitals, Sheffield Teaching Hospitals, Sheffield, United Kingdom

    Aim: This meta-analysis focuses on the current evidence of renal graft functioning and graft survival following early conversion to mTOR inhibitors with or without CNI…
  • 2017 American Transplant Congress

    Conversion from Calcineurin Inhibitor to Sirolimus in Kidney Transplantation Recipients with Malignancy.

    J. Yoon, S. Kang, S. Kim, C. Baeck, H. Kim, S.-K. Park.

    Nephrology, Asan Medical Center, Seoul, Republic of Korea

    Background: Kidney transplant recipients are at an increased risk of malignancy for various reasons, such as the chronic use of calcineurin inhibitor (CNI). Sirolimus (SRL),…
  • 2017 American Transplant Congress

    Efficacy of Calcineurin Inhibitors Transferring to Rapamycin in Live Kidney Transplantation from Old Donors to Young Recipients.

    G. Chen, C. Wang, Z. Wu, C. Wang, J. Qiu, L. Chen.

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Background Calcineurin inhibitor(CNI) nephrotoxicity is one of the major reasons for chronic allograft injury in live kidney transplantation from old donors to young recipients. Therefore…
  • 2017 American Transplant Congress

    Influence of Tacrolimus Metabolism Rate on Patients' Survival After Renal Transplantation.

    G. Thölking, J. Steinke, K. Schuette-Nuetgen, H. Pavenstädt, B. Suwelack, S. Reuter.

    Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Münster, Germany

    Introduction: Tacrolimus (Tac) is an integral part of the immunosuppressive regimen after renal transplantation (RTx). A fast Tac metabolism rate defined as the Tac blood…
  • 2017 American Transplant Congress

    Tacrolimus Appears to Be a Protective Factor for De Novo DSA Formation in Non-Sensitized Kidney Transplant Patients.

    M. Marron-Wojewodzki,1 I. Szwarc,1 C. Rene,2 G. Mourad,1 M. Le Quintrec.1,3

    1Department of Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, Montpellier, France; 2Departement of Immunology, Hôpital Saint Eloi, Montpellier, France; 3Inserm U1183,, IRMB,Hôpital Saint Eloi, Montpellier, France

    Background.Development of de novo donor specific antibodies (dnDSA) concerns about 10% of patients within the first year following kidney transplantation and reach about 20% within…
  • 2017 American Transplant Congress

    Early Exposure of Everolimus with and without Calcineurin Inhibitors.

    C. Felipe, A. Ferreira, T. Abait, A. Bessa, P. Ruppel, L. Hiramoto, M. Ivani, H. Tedesco, J. Medina- Pestana.

    Nephrology Division, Hospital do Rim, UNIFESP, São Paulo, SP, Brazil

    This study aimed to evaluate the effect of cyclosporine (CSA) or tacrolimus (TAC) on early exposure of everolimus (EVR).A cohort of 306 kidney transplant recipients…
  • 2017 American Transplant Congress

    Impact of Belatacept Conversion on Kidney Transplant Function, Histology and Gene Expression.

    P. Sanghi,1 G. Gupta,1 D. Kumar,1 J. Reeve,2 M. Levy,1 A. Sharma,1 H. Fattah,1 P. Kimball,1 H. Massey,1 A. King,1 P. Halloran.2

    1Virginia Commonwealth University, Richmond; 2Alberta Transplant Applied Genomics Center, Edmonton, Canada

    Background: Belatacept (bela) might be an alternative to Calcineurin Inhibitors (CNI) in order to avoid presumed nephrotoxicity. In this study we assessed the impact of…
  • 2017 American Transplant Congress

    Long-Term Preservation of Renal Function in Liver Transplant Recipients with Rabbit Anti-Thymocyte Globulin Induction and Delayed Initiation of Calcineurin Inhibitors.

    I. Bajjoka, A. Yaldo, C. Crombez, K. Brown, M. Abouljoud.

    Transplant Institute, Henry Ford Health System, Detroit, MI

    Methods: A single-center retrospective analysis of medical records of 989 liver transplant recipients from 2001-2010 were reviewed and evaluated for patients who received thymo induction…
  • 2017 American Transplant Congress

    Costimulatory Blockade in Delayed Graft Function.

    J. Von Visger,1 A. Diez,1 U. Nori,1 T. Pesavento,1 R. Pelletier,2 A. Rajab,2 A. El Hinnawi,2 H. Winters.3

    1Medicine, The Ohio State University, Columbus, OH; 2Surgery, The Ohio State University, Columbus, OH; 3Pharmacy, The Ohio State University, Columbus, OH

    Background: Delayed graft function (DGF) contributes to higher risk of rejection, poorer graft survival, hospital length of stay (LOS), and other morbidities. Studies also suggest…
  • 2017 American Transplant Congress

    Changes in Urinary Neutrophil Gelatinase Associated Lipocalin Combined with Urine Cytokines and Microalbuminuria as Predictors for Interstitial Fibrosis and Tubular Atrophy in Kidney Transplantation: A Matched-Pair Tissue Cohort Study.

    W. Chancharoenthana,1 A. Leelahavanichkul,1 S. Wattanatorn,1 J. Issara-Amphorn,2 Y. Avihingsanon,1 K. Praditpornsilpa,1 N. Townamchai.1

    1Division of Nephrology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; 2Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Background: Late graft loss from interstitial fibrosis - tubular atrophy (IF/TA) continues to be the “Achilles' heel” of kidney transplantation (KT). Long-term calcineurin inhibitors (CNIs)…
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