Articles tagged "Calcineurin"

2018 American Transplant Congress
Effect of Direct-Acting Hepatitis C Treatment Regimens on Calcineurin Inhibitors in Liver and Kidney Transplant Patients
M. Laub, J. Byrns, M. Harris, C. Berg, S. Sanoff.
Duke University Hospital, Durham, NC.
Background: It has been suggested that treatment with direct-acting antivirals (DAA) for hepatitis C virus (HCV) may decrease calcineurin inhibitor (CNI) concentrations. The purpose of…
2018 American Transplant Congress
The Providers Can't Let Go! An Analysis of an RN Driven Tacrolimus Dose Adjustment Protocol
Z. Elmaasarani, C. Mardis, L. Gylten, J. Fleming, H. Meadows, N. Patel, C. Perez, D. Taber, V. Rao, V. Rohan, P. Baliga, D. Dubay, N. Pilch.
MUSC, Charleston.
Introduction: Tacrolimus (FK) dose adjustment is frequently performed by non-MD staff. Standard protocols to evaluate the ability of non-providers to maintain pts within a goal…
2018 American Transplant Congress
Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study
S. Min,¹ T. Papaz,¹ T. Blydt-Hansen,³ O. Lee,¹ U. Allen,¹ P. Birk,² H. Grasemann,¹ L. Hamiwka,⁴ C. Litalien,⁵ V. Ng,¹ R. Parekh,¹ K. Tinckam,⁶ S. Urschel,⁷ B. Foster,⁸ S. Mital.¹
¹The Hospital for Sick Children, Toronto, Canada; ²Winnipeg Children's Hospital, Winnipeg, Canada; ³BC Children's Hospital, Vancouver, Canada; ⁴Alberta Children's Hospital, Calgary, Canada; ⁵CHU Ste-Justine, Montreal, Canada; ⁶University Health Network, Toronto, Canada; ⁷Stollery Children's Hospital, Edmonton, Canada; ⁸Montreal Children's Hospital, Montreal, Canada.
PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…
2018 American Transplant Congress
The Study of the Influence on hIAPP Deposition and Dysfunction in INS-1 Cell by Calcineurin Inhibitors
J. Zhang, W. Lv, C. Zhang, N. Sun, X. Li, Y. Shi, A. Jiao, J. Lin, Y. Lv.
Hepatobiliary Surgery Department and Unit of Organ Transplantation, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Background hIAPP is formed in islet β cells, misfolded hIAPP results in the deposition inside the β-cells and shows a damage to the β-cells. The…
2018 American Transplant Congress
Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
A. Leino,¹ C. Emoto,² T. Fukuda,² M. Privitera,¹ A. Vinks,^1,2 R. Alloway.¹
¹University of Cinninati, Cincinnati, OH; ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Cannabidiol (CBD), a major purified non-psychoactive component of marijuana with anticonvulsant properties, is being studied under an expanded access IND as an adjuvant treatment for…
2018 American Transplant Congress
The Effect of Tacrolimus Trough Level and Intrapatient Variability on the Transplant Outcomes in Kidney Transplantation
J. Lee,¹ J. Lee,¹ Y. Jung,¹ D. Kim,¹ S. Song,² J. Lee,³ J. Lee,¹ M. Kim,¹ S. Kim,¹ Y. Kim,¹ B. Kim,⁴ K. Huh.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Korea; ²Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; ³Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; ⁴Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.
Background: Tacrolimus (TAC) is the mainstay of immunosuppression for kidney transplantation (KT). Although TAC has a narrow therapeutic index, appropriate trough concentrations of TAC have…
2018 American Transplant Congress
Once Daily CNI Administration Based on Pharmacodynamic Analysis for Preventing Viral Infection
Y. Matsuoka,¹ K. Iwasaki,² Y. Miwa,² K. Horimi,¹ K. Uchida,² T. Kobayashi.¹
¹Renal Transplant Surgery, Aichi Medical University, Nagakute City, Aichi, Japan; ²Kidney Disease and Transplant Immunology, Aichi Medical University, Nagakute City, Aichi, Japan.
BackgroundInfectious complications under immunosuppressive therapy are inevitable problems. Viral infection (include reactivation) occurs at a certain frequency even if immunosuppressive agents are totally adjusted by…
2017 American Transplant Congress
Impact of Belatacept Conversion on Kidney Transplant Function, Histology and Gene Expression.
P. Sanghi,¹ G. Gupta,¹ D. Kumar,¹ J. Reeve,² M. Levy,¹ A. Sharma,¹ H. Fattah,¹ P. Kimball,¹ H. Massey,¹ A. King,¹ P. Halloran.²
¹Virginia Commonwealth University, Richmond; ²Alberta Transplant Applied Genomics Center, Edmonton, Canada
Background: Belatacept (bela) might be an alternative to Calcineurin Inhibitors (CNI) in order to avoid presumed nephrotoxicity. In this study we assessed the impact of…
2017 American Transplant Congress
Long-Term Preservation of Renal Function in Liver Transplant Recipients with Rabbit Anti-Thymocyte Globulin Induction and Delayed Initiation of Calcineurin Inhibitors.
I. Bajjoka, A. Yaldo, C. Crombez, K. Brown, M. Abouljoud.
Transplant Institute, Henry Ford Health System, Detroit, MI
Methods: A single-center retrospective analysis of medical records of 989 liver transplant recipients from 2001-2010 were reviewed and evaluated for patients who received thymo induction…
2017 American Transplant Congress
Costimulatory Blockade in Delayed Graft Function.
J. Von Visger,¹ A. Diez,¹ U. Nori,¹ T. Pesavento,¹ R. Pelletier,² A. Rajab,² A. El Hinnawi,² H. Winters.³
¹Medicine, The Ohio State University, Columbus, OH; ²Surgery, The Ohio State University, Columbus, OH; ³Pharmacy, The Ohio State University, Columbus, OH
Background: Delayed graft function (DGF) contributes to higher risk of rejection, poorer graft survival, hospital length of stay (LOS), and other morbidities. Studies also suggest…

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