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Articles tagged "Calcineurin"

  • 2018 American Transplant Congress

    Single-Dose Basiliximab Induction in Liver Transplant Recipients with Delayed CNI Initiation

    D. Salerno,1 N. Lange,1 R. Rosenblatt,2 C. Sammons,3 B. Fortune.2

    1Pharmacy, NewYork-Presbyterian Hospital, New York, NY; 2Medicine, Weill Cornell Medicine, New York, NY; 3Pharmacy, Hospital of the University of Pennsylvania, Philadelphia, PA.

    Liver transplant recipients (LTR) with peri-operative renal injury benefit from a delayed CNI protocol using basiliximab (IL2RA) induction to reduce early CNI exposure. Existing literature…
  • 2018 American Transplant Congress

    Tacrolimus Pharmacokinetics (PK) at Low, Medium, and High Trough Levels in Patients Converted from Twice-Daily Immediate-Release Tacrolimus (TacBID) to Once-Daily Extended-Release Tacrolimus (LCPT)

    P. Malvezzi,1 S. Bunnapradist,2 D. Stevens,3 M. Moten,3 A. Loh,3 S. Patel,3 L. Rostaing.1

    1Service De Néphrologie, Hémodialyse, Aphérèses Et Transplantation Rénale, Chu Grenoble Alpes, La Tronche, France; 2Nephrology, University of California, Los Angeles, Los Angeles, CA; 3Veloxis, Cary, NC.

    LCPT (Envarsus XR®) is a once-daily, extended-release formulation of tacrolimus which has demonstrated greater bioavailability and a smoother PK profile compared to TacBID. This post-hoc…
  • 2018 American Transplant Congress

    Outcomes in Liver Transplant Patients on Renal Sparing Protocol

    A. Polyak,1 D. Ganger,2 A. Shetty.2

    1New York Medical College, Valhalla, NY; 2Comprehensive Transplant Center, Northwestern University, Chicago, IL.

    As liver transplant outcomes have improved, long term native kidney function has taken a critical role in patient survival. Calcineurin inhibitors (CNIs), such as Tacrolimus…
  • 2018 American Transplant Congress

    Overexpression of BAX, NOL3, and XIAP Apoptotic Genes Participates in Calcineurin Inhibitors Nephrotoxicity: New Insights into Chronic Allograft Dysfunction

    L. Garcia-Covarrubias,1 G. Queipo,2 M. Fonseca,2 D. Alcantara,1 P. Prieto,1 H. Diliz,1 A. Garcia,1 H. Hinojosa,1 A. Cicero,1 G. Melendez,3 M. Alamilla,3 R. Lascurain,4 V. Soto.5

    1Transplantation, Hospital General de Mexico, Mexico City, Mexico; 2Genetics, Hospital General de Mexico, Mexico City, Mexico; 3Research, Hospital General de Mexico, Mexico City, Mexico; 4Faculty of Medicine, UNAM, Mexico City, Mexico; 5Pathology, Hospital General de Mexico, Mexico City, Mexico.

    Introduction: Calcineurin inhibitors toxicity (CNIT) is a factor that limit the outcome of renal transplantation graft. The hypoxia causes histological data as nodular hyalinosis, hyalinosis,…
  • 2018 American Transplant Congress

    Effect of Direct-Acting Hepatitis C Treatment Regimens on Calcineurin Inhibitors in Liver and Kidney Transplant Patients

    M. Laub, J. Byrns, M. Harris, C. Berg, S. Sanoff.

    Duke University Hospital, Durham, NC.

    Background: It has been suggested that treatment with direct-acting antivirals (DAA) for hepatitis C virus (HCV) may decrease calcineurin inhibitor (CNI) concentrations. The purpose of…
  • 2018 American Transplant Congress

    The Providers Can't Let Go! An Analysis of an RN Driven Tacrolimus Dose Adjustment Protocol

    Z. Elmaasarani, C. Mardis, L. Gylten, J. Fleming, H. Meadows, N. Patel, C. Perez, D. Taber, V. Rao, V. Rohan, P. Baliga, D. Dubay, N. Pilch.

    MUSC, Charleston.

    Introduction: Tacrolimus (FK) dose adjustment is frequently performed by non-MD staff. Standard protocols to evaluate the ability of non-providers to maintain pts within a goal…
  • 2018 American Transplant Congress

    Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study

    S. Min,1 T. Papaz,1 T. Blydt-Hansen,3 O. Lee,1 U. Allen,1 P. Birk,2 H. Grasemann,1 L. Hamiwka,4 C. Litalien,5 V. Ng,1 R. Parekh,1 K. Tinckam,6 S. Urschel,7 B. Foster,8 S. Mital.1

    1The Hospital for Sick Children, Toronto, Canada; 2Winnipeg Children's Hospital, Winnipeg, Canada; 3BC Children's Hospital, Vancouver, Canada; 4Alberta Children's Hospital, Calgary, Canada; 5CHU Ste-Justine, Montreal, Canada; 6University Health Network, Toronto, Canada; 7Stollery Children's Hospital, Edmonton, Canada; 8Montreal Children's Hospital, Montreal, Canada.

    PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…
  • 2017 American Transplant Congress

    Conversion from Calcineurin Inhibitor to Sirolimus in Kidney Transplantation Recipients with Malignancy.

    J. Yoon, S. Kang, S. Kim, C. Baeck, H. Kim, S.-K. Park.

    Nephrology, Asan Medical Center, Seoul, Republic of Korea

    Background: Kidney transplant recipients are at an increased risk of malignancy for various reasons, such as the chronic use of calcineurin inhibitor (CNI). Sirolimus (SRL),…
  • 2017 American Transplant Congress

    Efficacy of Calcineurin Inhibitors Transferring to Rapamycin in Live Kidney Transplantation from Old Donors to Young Recipients.

    G. Chen, C. Wang, Z. Wu, C. Wang, J. Qiu, L. Chen.

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Background Calcineurin inhibitor(CNI) nephrotoxicity is one of the major reasons for chronic allograft injury in live kidney transplantation from old donors to young recipients. Therefore…
  • 2017 American Transplant Congress

    Influence of Tacrolimus Metabolism Rate on Patients' Survival After Renal Transplantation.

    G. Thölking, J. Steinke, K. Schuette-Nuetgen, H. Pavenstädt, B. Suwelack, S. Reuter.

    Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Münster, Germany

    Introduction: Tacrolimus (Tac) is an integral part of the immunosuppressive regimen after renal transplantation (RTx). A fast Tac metabolism rate defined as the Tac blood…
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