Articles tagged "Bone marrow transplantation"

2015 American Transplant Congress
Recipient IL-33 Promotes Type 1 Alloimmunity and Lethal Acute GVHD Following alloHCT
B. Matta,¹ D. Reichenbach,² V. Schwarze,³ V. Tkachev,⁴ L. Mathews,¹ Q. Liu,¹ M. Warncke,⁵ J. Ferrara,⁴ R. Zeiser,³ B. Blazar,² H. Turnquist.¹
¹Surgery, Univ. of Pittsburgh, Pittsburgh, PA; ²Pediatrics, Univ. of Minnesota, Minneapolis, MN; ³Hematology and Oncology, Univ. Medical Center Freiburg, Freiburg, Germany; ⁴Pediatrics, Univ. of Michigan, Ann Arbor, MI; ⁵Novartis Institute for Biomedical Research, Basel, Switzerland.
Background: Graft-versus-host disease (GVHD) is a common complication of allogeneic (allo) hematopoietic cell transplantation (HCT) that limits its widespread application for the induction of transplant…
2015 American Transplant Congress
Donor Specific Tolerance Can Be Induced by Donor Bone Marrow Transfer With Activation of Invariant Naturel Killer T Cells
S. Miyairi,¹ T. Hirai,¹ R. Shibahara,¹ K. Omoto,¹ S. Nunoda,² K. Yamazaki,² Y. Ishii,³ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; ²Cardiovascular Surgery, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; ³Laboratory of Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
It has been reported that liposomal formulation of a-galactosylceramide(lipo-aGC) could induce antigen specific regulatory T cells (Treg) in vivo when administered with particular antigens. We…
2015 American Transplant Congress
Combined Bone Marrow Plus Liver Transplantation in Cynomolgus Monkeys
J. Weiner, Y. Kato, R. Duran-Struuck, M. Martinez, S. Baker, P. Alonso, J. Zitsman, A. Wu, P. Houck, T. Pinyavat, J. Lefkowitch, S. Chaudhry, T. Kato, M. Sykes, A. Griesemer.
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
IntroductionCombined kidney/bone marrow transplantation (CKBMT) induces tolerance in both primates and humans. Since liver is thought to be more tolerogenic than kidney, we hypothesized that…
2015 American Transplant Congress
Differential Expression and Function of ASC and Nlrp3 Inflammasome Adaptors in Hematopoietic Stem Cells (HSCs)
A. Scheinok, R. Elahimehr, A. Shigeoka, S. Kasimsetty, D. McKay.
Medicine, University of California San Diego, San Diego, CA.
HSCs are activated by pattern recognition receptors (PRRs), which might provide novel targets for improved engraftment. How PRRs affect HSC engraftment after BM transplantation is…
2015 American Transplant Congress
CD8⁺TCR^– Bone Marrow Facilitating Cells Prime Migration and Enhance Homing of Hematopoietic Stem and Progenitor Cells
Y. Wen,¹ Y. Huang,¹ T. Miller,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
We recently reported the induction of chimerism and tolerance to renal allografts without GVHD or engraftment syndrome in HLA-mismatched living donor renal transplant recipients through…
2015 American Transplant Congress
The Role of an Intragraft Vascularized Bone Marrow Niche in Establishing Mixed Chimerism and Allograft Acceptance
M. Fryer, B. Oh, G. Furtmüller, G. Raimondi, G. Brandacher.
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.
Background: Vascularized composite allotransplantation has emerged as a viable treatment option for patients with devastating tissue loss not amenable to traditional reconstructive techniques. Different from…