Articles tagged "Bone marrow transplantation"

2016 American Transplant Congress
Tolerance Induction with Donor Bone Marrow Transplantation in Kidney Transplantation.
H. Park,¹ N. Lee,¹ S. Lee,¹ G. Choi,¹ C. Kwon,¹ S. Kim,¹ J.-W. Joh,¹ M. Kim,² Y. Kwon,² S.-K. Lee.¹
¹Department of Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea; ²Transplantation Research Center, Samsung Biomedical Research Institute, Seoul, Republic of Korea.
Tolerance induction is considered to be a final goal in the field of organ transplantation. We have performed simultaneous bone marrow and kidney transplantation in…
2016 American Transplant Congress
Direct IL-33 Stimulation of T Regulatory Cells via Suppression of Tumorigenicity 2 (ST2) Is Required for Effective Control of Alloimmune Responses.
X. Zhang,^1,3 B. Matta,¹ D. Reichenbach,² B. Blazar,² H. Turnquist.¹
¹Dept of Surgery, Starzl Transplantation Inst, Pittsburgh, PA; ²Dept of Pediatrics, Univ of Minnesota, Minneapolis, MN; ³Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Background: IL-33 is a pleotropic cytokine that can protect against cardiac transplant rejection by expanding regulatory T cells (Treg), particularly a Treg subset expressing the…
2016 American Transplant Congress
Long-Lasting Skin Allograft Tolerance Induced and Maintained by Short-Term Vascularized Bone Marrow Transplant in a Mouse Model.
C.-H. Lin,¹ M. Anggelia,¹ H.-Y. Cheng,¹ Y.-L. Wang,¹ W.-Y. Chuang,¹ C.-H. Lin,¹ G. Brandacher.²
¹Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Accumulating evidences indicate that vascularized bone marrow transplantation (VBMT) plays a critical role in inducing tolerance of vascularized composite allografts (VCA). Recipients with long-term…
2016 American Transplant Congress
Post Transplantation High-Dose Cyclophosphamide Treatment Promotes Immune Tolerance After Skin, Solid Organ, and Vascularized Composite Allotransplantation.
G. Furtmüller,¹ B. Oh,¹ M. Fryer,^1,4 P. Akre,¹ S. Ganguly,² J. Dodd-o,³ D. Cooney,¹ G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore, MD; ²Immunology - Sydney Kimmel Cancer Center, Johns Hopkins Medicine, Baltimore, MD; ³Department of Anesthesiology, Johns Hopkins Medicine, Baltimore, MD; ⁴Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA.
Background: Developing novel approaches to minimize/avoid immunosuppression by induction of immune tolerance represents the prime task in the field of transplantation. Methods: Murine skin, heart,…
2015 American Transplant Congress
Absence of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and 2 Modifies Adaptive Immune Responses
S. Kasimsetty, A. Shigeoka, D. McKay.
Medicine, UCSD, La Jolla, CA.
Background:The NOD family of intracellular pattern recognition receptors (PRRs) plays a key role in immune responses to microbial and danger signals. This family of proteins…
2015 American Transplant Congress
High Incidence of Masked Hypertension in Pediatric Recipients of Stem Cell Transplantation
A. Melk,¹ D. Thurn-Valsassina,¹ B. Schmidt,² R. Beier.³
¹Pediatric Nephrology, Hannover Medical School, Hannover, Germany; ²Nephrology, Hannover Medical School, Hannover, Germany; ³Pediatric Hematology, Hannover Medical School, Hannover, Germany.
Purpose: Different from recipients of a solid organ transplant, stem cell transplantation (SCT) recipients do not receive long term immunosuppressive treatment that may cause renal…
2015 American Transplant Congress
Kidney Transplantation After Hematopoietic Cell Transplantation in Plasma Cell Dyscrasias
V. Domínguez-Pimentel,¹ F. Fortich-Barrios,¹ O. Siverio-Morales,¹ E. Martín-Izquierdo,¹ A. Jarque-López,¹ N. Del Castillo-Rodríguez,¹ J. García,¹ P. Ríos,² M. Macía.¹
¹Division of Nephrology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain; ²Division of Hematology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain.
INTRODUCTION:The plasma cell dyscrasias (PCD) include a number of entities such as multiple myeloma (MM), primary amyloidosis (AL) and Monoclonal immunoglobulin deposition disease (MIDD). Hematopoietic…
2015 American Transplant Congress
Chest Wall,Thymus, and Heart Transplant: Pushing the Boundary of Solid Organ Allotransplantation
G. Torregrossa,¹ M. Sosin,² G. Gerosa,³ A. Dorafshar.²
¹Cardiothoracic Surgery, Mount Sinai Hospital, NYC, NY; ²Plastic and Reconstructive Surgery, Johns Hopkins Hospital, Baltimore, MD; ³Cardiac Surgery, Universita'di Padova, Padova, Italy.
Objective:The last 10 years have ushered in the clinical reality of upper extremity and face transplantation with animal models and basic science evidence to support…
2015 American Transplant Congress
ALDH Expression in Facilitating Cells Plays a Critical Role in Regulatory T Cell Induction and GVHD Prevention
H. Xu,¹ T. Miller,¹ Y. Huang,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
Graft-vs-host disease (GVHD) is a major source of morbidity in hematopoietic stem cell transplantation (HSCT), limiting its application to treat nonmalignant hematopoietic diseases and to…
2015 American Transplant Congress
Vascularized Bone Marrow Plays a Critical Role in Inducing Tolerance of Osteomyocutaneous Allografts
C.-H. Lin,¹ M. Anggelia,¹ Y.-L. Wang,¹ H.-Y. Cheng,¹ W. Lee,² G. Brandacher.²
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taipei, Taiwan; ²Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Vascularized composite allograft (VCA) that includes medullary bone may provide proposed benefits ofvascularized bone marrow transplantation (VBMT), such as a continuous supply of donor…