ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bone marrow transplantation"

  • 2017 American Transplant Congress

    Depletion of T-Cells from G-CSF Mobilized Human PBMC Prevents Acute GVHD in NSG Mice.

    Y. Huang, H. Xu, A. Merchak, A. Chhabra, Y. Wen, L. Kahn, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY

    Allogeneic HSC transplantation is commonly utilized for the treatment of hematologic malignancies and autoimmune diseases. However, allogeneic HSC transplantation is limited by potential for the…
  • 2016 American Transplant Congress

    Tolerance Induction with Donor Bone Marrow Transplantation in Kidney Transplantation.

    H. Park,1 N. Lee,1 S. Lee,1 G. Choi,1 C. Kwon,1 S. Kim,1 J.-W. Joh,1 M. Kim,2 Y. Kwon,2 S.-K. Lee.1

    1Department of Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea; 2Transplantation Research Center, Samsung Biomedical Research Institute, Seoul, Republic of Korea.

    Tolerance induction is considered to be a final goal in the field of organ transplantation. We have performed simultaneous bone marrow and kidney transplantation in…
  • 2016 American Transplant Congress

    Direct IL-33 Stimulation of T Regulatory Cells via Suppression of Tumorigenicity 2 (ST2) Is Required for Effective Control of Alloimmune Responses.

    X. Zhang,1,3 B. Matta,1 D. Reichenbach,2 B. Blazar,2 H. Turnquist.1

    1Dept of Surgery, Starzl Transplantation Inst, Pittsburgh, PA; 2Dept of Pediatrics, Univ of Minnesota, Minneapolis, MN; 3Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

    Background: IL-33 is a pleotropic cytokine that can protect against cardiac transplant rejection by expanding regulatory T cells (Treg), particularly a Treg subset expressing the…
  • 2016 American Transplant Congress

    Long-Lasting Skin Allograft Tolerance Induced and Maintained by Short-Term Vascularized Bone Marrow Transplant in a Mouse Model.

    C.-H. Lin,1 M. Anggelia,1 H.-Y. Cheng,1 Y.-L. Wang,1 W.-Y. Chuang,1 C.-H. Lin,1 G. Brandacher.2

    1Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.

    Background: Accumulating evidences indicate that vascularized bone marrow transplantation (VBMT) plays a critical role in inducing tolerance of vascularized composite allografts (VCA). Recipients with long-term…
  • 2016 American Transplant Congress

    Post Transplantation High-Dose Cyclophosphamide Treatment Promotes Immune Tolerance After Skin, Solid Organ, and Vascularized Composite Allotransplantation.

    G. Furtmüller,1 B. Oh,1 M. Fryer,1,4 P. Akre,1 S. Ganguly,2 J. Dodd-o,3 D. Cooney,1 G. Raimondi,1 W. Lee,1 L. Luznik,2 G. Brandacher.1

    1Department of Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore, MD; 2Immunology - Sydney Kimmel Cancer Center, Johns Hopkins Medicine, Baltimore, MD; 3Department of Anesthesiology, Johns Hopkins Medicine, Baltimore, MD; 4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA.

    Background: Developing novel approaches to minimize/avoid immunosuppression by induction of immune tolerance represents the prime task in the field of transplantation. Methods: Murine skin, heart,…
  • 2016 American Transplant Congress

    Administration of IL-33 Before Allogeneic Stem Cell Transplantation Expands Recipient Treg That Prevent Graft- vs. Host Disease.

    B. Matta,1 D. Reichenbach,2 X. Zhang,1 B. Koehn,2 L. Mathews,1 C. Feser,2 M. Smith,2 Q. Liu,1 R. Zeiser,3 B. Blazar,2 H. Turnquist.1

    1Dept of Surgery and Starzl Transplant Inst, Univ of Pittsburgh Sch of Med, Pittsburgh, PA; 2Dept of Pediatrics, Univ of Minnesota, Minneapolis, MN; 3Univ Med Cntr Freiburg, Freiburgh, Germany.

    Background: During allogeneic hematopoietic cell transplantation (alloHCT), non-hematopoietic cell IL-33 is augmented and released by recipient conditioning to promote Type 1 alloimmunity and lethal acute…
  • 2016 American Transplant Congress

    iNKT Cell Activation Under Co-Stimulatory Blockade Establishes Mixed Chimerism Through Thymic Regulatory T Cell Activation.

    T. Hirai,1 Y. Ishii,2 R. Ishii,1 S. Miyairi,1 M. Ikemiyagi,1 M. Okumi,1 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; 2Laboratory for Vaccine Design, RIKEN-IMS, Yokohama, Kanagawa, Japan.

    Background: Invariant natural killer T (iNKT) cells have recently garnered considerable attention for their potential to induce regulatory T cells (Tregs). We previously reported a…
  • 2016 American Transplant Congress

    The Function of CD8+TCR– Facilitating Cells and Regulatory T Cells Is Impaired in Flt3-Ligand Knockout Mice.

    Y. Huang, H. Xu, T. Miller, Y. Wen, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Graft CD8+TCR- facilitating cells (FC) enhance engraftment of hematopoietic stem cells (HSC) in allogeneic mouse recipients without causing graft-versus-host disease. FC induce antigen-specific CD4+CD25+FoxP3+ regulatory…
  • 2016 American Transplant Congress

    Absence of Host CD137 Signaling Converts Chronic GVHD Toward Acute GVHD.

    H. Cho,1,3 J. Lee,1,4 J. Kim,1 U. Moon,1 B. Kwon,1,2 S. Park,3 K. Park.4

    1Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; 2School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea; 3Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; 4Department of Internal Medicine, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea.

    CD137 functions mainly as a costimulatory molecule for T cell activation. However, its functions have been found in a variety of other immune and nonimmune…
  • 2016 American Transplant Congress

    Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.

    S. Miyairi,1,2 T. Hirai,1 R. IShii,1 M. Okumi,1 Y. Ishii,3 S. Nunoda,2 K. Yamazaki,2 K. Tanabe.1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; 3Laboratory of Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.

    Calcineurin (CN)-dependent IL-2 production is crucial for regulatory T cells (Tregs) to demonstrate suppressive activity. The mTOR signal is not required for Treg function because…
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