ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bone marrow transplantation"

  • 2017 American Transplant Congress

    Depletion of T-Cells from G-CSF Mobilized Human PBMC Prevents Acute GVHD in NSG Mice.

    Y. Huang, H. Xu, A. Merchak, A. Chhabra, Y. Wen, L. Kahn, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY

    Allogeneic HSC transplantation is commonly utilized for the treatment of hematologic malignancies and autoimmune diseases. However, allogeneic HSC transplantation is limited by potential for the…
  • 2016 American Transplant Congress

    Administration of IL-33 Before Allogeneic Stem Cell Transplantation Expands Recipient Treg That Prevent Graft- vs. Host Disease.

    B. Matta,1 D. Reichenbach,2 X. Zhang,1 B. Koehn,2 L. Mathews,1 C. Feser,2 M. Smith,2 Q. Liu,1 R. Zeiser,3 B. Blazar,2 H. Turnquist.1

    1Dept of Surgery and Starzl Transplant Inst, Univ of Pittsburgh Sch of Med, Pittsburgh, PA; 2Dept of Pediatrics, Univ of Minnesota, Minneapolis, MN; 3Univ Med Cntr Freiburg, Freiburgh, Germany.

    Background: During allogeneic hematopoietic cell transplantation (alloHCT), non-hematopoietic cell IL-33 is augmented and released by recipient conditioning to promote Type 1 alloimmunity and lethal acute…
  • 2016 American Transplant Congress

    iNKT Cell Activation Under Co-Stimulatory Blockade Establishes Mixed Chimerism Through Thymic Regulatory T Cell Activation.

    T. Hirai,1 Y. Ishii,2 R. Ishii,1 S. Miyairi,1 M. Ikemiyagi,1 M. Okumi,1 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; 2Laboratory for Vaccine Design, RIKEN-IMS, Yokohama, Kanagawa, Japan.

    Background: Invariant natural killer T (iNKT) cells have recently garnered considerable attention for their potential to induce regulatory T cells (Tregs). We previously reported a…
  • 2016 American Transplant Congress

    The Function of CD8+TCR– Facilitating Cells and Regulatory T Cells Is Impaired in Flt3-Ligand Knockout Mice.

    Y. Huang, H. Xu, T. Miller, Y. Wen, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Graft CD8+TCR- facilitating cells (FC) enhance engraftment of hematopoietic stem cells (HSC) in allogeneic mouse recipients without causing graft-versus-host disease. FC induce antigen-specific CD4+CD25+FoxP3+ regulatory…
  • 2016 American Transplant Congress

    Absence of Host CD137 Signaling Converts Chronic GVHD Toward Acute GVHD.

    H. Cho,1,3 J. Lee,1,4 J. Kim,1 U. Moon,1 B. Kwon,1,2 S. Park,3 K. Park.4

    1Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; 2School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea; 3Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; 4Department of Internal Medicine, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea.

    CD137 functions mainly as a costimulatory molecule for T cell activation. However, its functions have been found in a variety of other immune and nonimmune…
  • 2016 American Transplant Congress

    Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.

    S. Miyairi,1,2 T. Hirai,1 R. IShii,1 M. Okumi,1 Y. Ishii,3 S. Nunoda,2 K. Yamazaki,2 K. Tanabe.1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; 3Laboratory of Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.

    Calcineurin (CN)-dependent IL-2 production is crucial for regulatory T cells (Tregs) to demonstrate suppressive activity. The mTOR signal is not required for Treg function because…
  • 2016 American Transplant Congress

    Three-Year Outcome After HSCT with Subsequent KT from the Same Haploidentical Donor without Immunosuppression.

    C. Schwarz,1 A. Lawitschka,2 G. Böhmig,3 E. Dauber,4 H. Greinix,5 N. Kozakowski,6 F. Mühlbacher,1 G. Berlakovich,1 T. Wekerle.7

    1Dept. of Surgery, Div. of Transplantation, Medeical University of Vienna, Vienna, Austria; 2St. Anna Children's Hospital, Vienna, Austria; 3Dept. of Internal Medicine, Division of Nephrology, Medical University of Vienna, Vienna, Austria; 4Dept. of Transfusion Medicine, Medical University of Vienna, Vienna, Austria; 5Dept of Internal Medicine, Div of Hematology, Medical University of Graz, Graz, Austria; 6Dept. of Clinical Pathology, Medical University of Vienna, Vienna, Austria; 7Section of Transplantation Immunology, Dept. of Surgery, Medical University of Vienna, Vienna, Austria.

    Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to donor-specific tolerance. Patients reported in the literature that underwent kidney transplantation (KT) after a previous HSCT…
  • 2016 American Transplant Congress

    Nontuberculous Mycobacterial Infection Among Allogeneic Hematopoietic Stem Cell Transplant Recipients: A 16-Year Cohort Study.

    A. Alghamdi, J. Lipton, C. Rotstein, D. Kumar, A. Humar, T. Mazzulli, S. Husain.

    University Health Network, Toronto, Canada.

    Background: Nontuberculous mycobacteria (NTM) infections in hematopoietic stem cell transplant (HSCT) recipients can be associated with significant morbidity and mortality.Methods: We identified all allogeneic HSCT…
  • 2016 American Transplant Congress

    Hematopoietic Cell Transplant and Solid Organ Transplantation: A First Report of the U.S. Experience.

    M. Gupta, M. Levine, P. Abt.

    Surgery, Division of Transplant Surgery, University of Pennsylvania, Philadelphia, PA.

    The prevalence of patients who receive both a hematopoetic cell(HCT) and solid organ transplantation(SOT) is rising. There have been no large scale studies of HCT…
  • 2016 American Transplant Congress

    HLA Identical or Haploidentical Combined Kidney and Bone Marrow Transplantation for Multiple Myeloma with End-Stage Renal Failure.

    T. Kawai,1 Y.-B. Chen,1 M. Sykes,2 C. Benedict,1 N. Tolkoff-Rubin,1 B. Day,1 S. McAfee,1 K. Ballen, S. David,1 T. Spitzer.1

    1Massachusetts General Hospital, Boston; 2Columbia University, New York.

    Patients with multiple myeloma (MM) who developed end-stage renal disease (ESRD) are generally not eligible for either kidney transplantation or allogeneic stem-cell transplant. We performed…
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