2017 American Transplant Congress
iNKT Cell Activation Plus Veto Cell Transfer Yields Complete Chimerism in a Murine Sub-Lethal Bone Marrow Transplant Model.
Transplant tolerance induction makes it possible to preserve functional grafts for a lifetime without immunosuppressants. We have previously established a novel method for mixed chimera…2016 American Transplant Congress
iNKT Cell Activation Under Co-Stimulatory Blockade Establishes Mixed Chimerism Through Thymic Regulatory T Cell Activation.
Background: Invariant natural killer T (iNKT) cells have recently garnered considerable attention for their potential to induce regulatory T cells (Tregs). We previously reported a…2016 American Transplant Congress
The Function of CD8+TCR– Facilitating Cells and Regulatory T Cells Is Impaired in Flt3-Ligand Knockout Mice.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Graft CD8+TCR- facilitating cells (FC) enhance engraftment of hematopoietic stem cells (HSC) in allogeneic mouse recipients without causing graft-versus-host disease. FC induce antigen-specific CD4+CD25+FoxP3+ regulatory…2016 American Transplant Congress
Absence of Host CD137 Signaling Converts Chronic GVHD Toward Acute GVHD.
CD137 functions mainly as a costimulatory molecule for T cell activation. However, its functions have been found in a variety of other immune and nonimmune…2016 American Transplant Congress
Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.
Calcineurin (CN)-dependent IL-2 production is crucial for regulatory T cells (Tregs) to demonstrate suppressive activity. The mTOR signal is not required for Treg function because…2016 American Transplant Congress
Three-Year Outcome After HSCT with Subsequent KT from the Same Haploidentical Donor without Immunosuppression.
Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to donor-specific tolerance. Patients reported in the literature that underwent kidney transplantation (KT) after a previous HSCT…2016 American Transplant Congress
Nontuberculous Mycobacterial Infection Among Allogeneic Hematopoietic Stem Cell Transplant Recipients: A 16-Year Cohort Study.
University Health Network, Toronto, Canada.
Background: Nontuberculous mycobacteria (NTM) infections in hematopoietic stem cell transplant (HSCT) recipients can be associated with significant morbidity and mortality.Methods: We identified all allogeneic HSCT…2016 American Transplant Congress
Hematopoietic Cell Transplant and Solid Organ Transplantation: A First Report of the U.S. Experience.
Surgery, Division of Transplant Surgery, University of Pennsylvania, Philadelphia, PA.
The prevalence of patients who receive both a hematopoetic cell(HCT) and solid organ transplantation(SOT) is rising. There have been no large scale studies of HCT…2016 American Transplant Congress
HLA Identical or Haploidentical Combined Kidney and Bone Marrow Transplantation for Multiple Myeloma with End-Stage Renal Failure.
1Massachusetts General Hospital, Boston; 2Columbia University, New York.
Patients with multiple myeloma (MM) who developed end-stage renal disease (ESRD) are generally not eligible for either kidney transplantation or allogeneic stem-cell transplant. We performed…2016 American Transplant Congress
Tolerance Induction with Donor Bone Marrow Transplantation in Kidney Transplantation.
Tolerance induction is considered to be a final goal in the field of organ transplantation. We have performed simultaneous bone marrow and kidney transplantation in…
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