Articles tagged "Biopsy"

2021 American Transplant Congress
Comparison of Donor-derived Cell Free Dna Between Recipients with First Solitary Allograft and Regrafts
S. Paluri¹, S. Muthusamy¹, M. Shinbashi¹, G. Gupta¹, B. Dale², Z. Kashi³, P. Halloran⁴, D. Kumar¹
¹Virginia Commonwealth University, Richmond, VA, ²CareDx, Brisbane, CA, ³Kashi Clinical Laboratories, Portland, OR, ⁴ATAGC, Edmonton, AB, Canada
*Purpose: Donor derived-cell free DNA (dd-cfDNA) is a biomarker of immunological injury. Multiple studies have validated its utility in recipients of first solitary kidney transplants…
2021 American Transplant Congress
Given the Potential Impact on Liver Transplant Selection, Revisiting the Current Standard of Diagnosis of Hepatocellular Carcinoma
K. Amarell, B. Fisher, B. Park, K. Ko, B. Kallakury
Department of Pathology & Laboratory Medicine, Georgetown University School of Medicine, Washington, DC
*Purpose: The current standard of diagnosis of hepatocellular carcinoma (HCC) relies on non-invasive radiographic methods, namely computerized tomography (CT) and/or magnetic resonance imaging (MRI). However,…
2021 American Transplant Congress
Liver Biopsy as a Predictor in Risk Stratification for Heart Transplant Candidates
S. Tolia¹, T. Al Saadi¹, N. Narang², A. Joshi², C. Sciamanna², S. Pauwaa², G. Macaluso², M. Dia², A. Tatooles³, P. Pappas³, W. Cotts², A. Andrade²
¹Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL, ²Cardiology, Advocate Christ Medical Center, Oak Lawn, IL, ³Cardiovascular Surgery, Advocate Christ Medical Center, Oak Lawn, IL
*Purpose: Patients undergoing workup for Orthotopic Heart Transplant (OHT) undergo multi-organ evaluation for risk stratification. While cirrhosis is a known predictor of poor outcomes in…
2021 American Transplant Congress
Blood Gene Expression and Donor-derived Cell Free DNA for Diagnosing Subclinical Acute Rejection in Stable Kidney Transplant Recipients
S. Park¹, K. Guo², H. Raymond³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁸, J. Holman⁹, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹⁰, J. Friedewald¹
¹Transplant Nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Transplant Genomics, Inc, Mansfield, MA, ¹⁰University of Arizona College of Medicine, Tucson, AZ
*Purpose: A blood gene expression profile (GEP) has been established as a non-invasive screen for subclinical acute rejection (subAR). For patients with allograft dysfunction, donor-derived…
2021 American Transplant Congress
Macrosteatosis in the US Pediatric Deceased Liver Donor Population, 2005-2018
J. Purvis, D. Dhall, C. McLeod, S. Sheikh, R. Cannon, K. Frey, J. Locke, B. Orandi
University of Alabama School of Medicine, Birmingham, AL
*Purpose: The pediatric obesity epidemic is associated with early signs of non-alcoholic fatty liver disease (NAFLD) such as increased hepatic macrosteatosis and liver enzymes. In…
2021 American Transplant Congress
Prevalence of Diabetic Changes on Kidney Allograft Biopsies of Normoglycemic Simultaneous Pancreas-Kidney Transplant Recipients
C. Mejia, G. Giannini, D. C. Brennan, A. Rosenberg, S. Alasfar
Johns Hopkins University, Baltimore, MD
*Purpose: Small studies suggest that achieving normoglycemia with simultaneous pancreas-kidney transplant (SPK) prevents the development of diabetic nephropathy (DN) among type 1 diabetics (T1DM). However,…
2021 American Transplant Congress
Core Signature of Rejection-Specific Cytokines and Chemokines in Heart Biopsies After Transplantation
L. M. Radomsky¹, Y. Scheibner², J. F. Kuehne¹, J. Keil¹, K. Beushausen¹, K. Ludmilla², A. Schick², F. Ius², G. Warnecke³, C. Bara², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Clinic for Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
*Purpose: Allograft rejection remains one of the limiting factors for survival after HTX. The aim of this project was to characterize the cytokine/chemokine network in…
2021 American Transplant Congress
Baseline Levels of Dd-cf Dna After Pancreas Transplantation: Using Dd-cfdna as an Indicator for Pancreas Rejection and Biopsy Avoidance
A. Yoo, I. Qian, A. Riedel, C. Cazac, A. Bartosic, J. S. Bromberg, J. Scalea
Department of Surgery, Division of Transplant, University of Maryland School of Medicine, Baltimore, MD
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) testing, which has been previously validated for monitoring kidney transplant (KTx) rejection, may provide an alternative to pancreas biopsy that…
2021 American Transplant Congress
Impact of Donor Kidney Biopsy on Kidney Yield and Post-Transplant Outcomes
C. Wang¹, J. Wetmore¹, A. Wey², N. Salkowski², J. Snyder², A. Israni¹
¹Nephrology, Hennepin County Medical Center, Minneapolis, MN, ²Scientific Registry of Transplant Recipients, Minneapolis, MN
*Purpose: Kidney procurement biopsy findings, such as Glomerulosclerosis (GS) is frequently used to determine kidney quality, but it remains unclear the degree of GS in…
2021 American Transplant Congress
Evaluation of Serum Klotho Levels at Early Kidney Post-Transplant
T. Vazquez-Sanchez¹, J. Alonso-Titos¹, M. Sánchez-Niño², E. Sola¹, M. Leon³, V. Lopez¹, P. Ruiz-Esteban¹, E. Porrini⁴, A. Ortiz⁵, D. Hernández¹
¹Nephrology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Malaga, Spain, ²Nephrology, Instituto de InvestigaciónSanitaria de la FundaciónJiménez Díaz,UniversidadAutónoma de Madrid. REDINREN, Madrid, Spain, ³Pathology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Malaga, Spain, ⁴Nephrology, Hospital Universitario de Canarias, CIBICAN, Universidadde laLaguna, REDinREN (RD16/0009/0031) Tenerife e Instituto Reina Sofía de Investigación Renal (IRSIN), Malaga, Spain, ⁵Nephrology, Instituto de InvestigaciónSanitaria de la FundaciónJiménez Díaz,UniversidadAutónoma de Madrid. REDINREN, Malaga, Spain
*Purpose: Klotho expression is lowered in patients with chronic kidney disease (CKD). After kidney transplant (KT), serum Klotho levels could be significantly increased compared to…

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