2021 American Transplant Congress
Effect of Donor Glomerulosclerosis and Interstitial Fibrosis/Tubular Atrophy (IFTA) on Kidney Graft Survival: A Single Organ Procurement Organization (OPO) Data
1Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 2OneLegacy, Los Angeles, CA
*Purpose: The kidneys of deceased donors are often biopsied to evaluate transplant organ quality. A high percentage of GS is a leading cause of kidney…2021 American Transplant Congress
Beyond Microarrays: Insights from Ncounter Transcript Analysis of Routine Archival Kidney Allograft Biopsies
Massachusetts General Hospital, Boston, MA
*Purpose: Microarray mRNA analysis of renal allograft biopsies has discovered important insights, but has limitations as a practical clinical test. Here we evaluate a new…2021 American Transplant Congress
Kidney Transplant Survival After Borderline Rejection in the Setting of Denovo Dsa Formation
*Purpose: The significance of borderline cellular rejection has been questioned in the past. Data on borderline rejection with deNovo DSA (dnDSA) formation is limited. We…2021 American Transplant Congress
Transplant Glomerulopathy in the Absence of Donor-specific HLA Antibodies: Risk Factors, Histopathological Features and Graft Outcome
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Transplant glomerulopathy (TG) is established as a hallmark of chronic antibody-mediated rejection in kidney transplant patients with donor-specific HLA antibodies (HLA-DSA). The clinical importance…2021 American Transplant Congress
Impact of Treatment of Subclinical Rejection at 2 Weeks After Kidney Transplantation, Compared by 1 Year Histologic Outcomes
*Purpose: Subclinical rejection (SCR) is associated with chronic allograft nephropathy, which is the most common cause of allograft failure in kidney transplantation (KT). Therefore, early…2021 American Transplant Congress
Effect of Early Biopsy-Proven Rejection on Liver Transplant Outcomes
Surgery, University of Wisconsin, Madison, WI
*Purpose: Existing literature offers conflicting conclusions about whether early acute cellular rejection influences long-term outcomes in liver transplantation.*Methods: We retrospectively collected donor and recipient data…2021 American Transplant Congress
Role of Serial Donor Derived Cell-Free DNA Monitoring in Kidney Transplant Recipients
Nephrology, Stanford University School of Medicine, Palo Alto, CA
*Purpose: Donor derived cell-free DNA (dd cf-DNA; Allosure, CareDx) is increasingly employed for non-invasive kidney transplant monitoring. The goal of this study was 1) to…2021 American Transplant Congress
The Risk of Post-donation Kidney Function Impairment for Prospective Living Kidney Donors with Persistent Isolated Microscopic Hematuria
*Purpose: According to current guidelines, a kidney biopsy is indicated in prospective living kidney donors who present with persistent isolated microscopic hematuria (PIMH) during evaluation,…2021 American Transplant Congress
Donor Derived Cell Free Dna: Teasing Out the Optimal Threshold for Antibody Mediated Rejection
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) assay is a putative noninvasive marker for renal allograft rejection and other etiologies of injury such as BK nephropathy. The…2021 American Transplant Congress
First Full Reversal of Diabetes in Non-human Primates (nhp) with Stem Cell Derived Islet-like-clusters (sc-ilcs)
*Purpose: Deceased donor allo-islet transplants (Tx) have demonstrated the ability of cell-based therapy to fully reverse T1D, however, an inadequate donor supply and frequent need…
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