Articles tagged "Biopsy"

2018 American Transplant Congress
Is the NETos Increased in Acute Antibody Mediated Rejection?
R. Villca-Gonzales,¹ J. Torres-Ruiz,² D. Gomez-Martin,² J. Alberu,³ L. Morales-Buenrostro.¹
¹Nephrology, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico; ²Immunology, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico; ³Transplantation, Inst. Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, CDMX, Mexico.
Neutrophils can promote graft inflammation through a form of programmed cell death termed "NETosis". How alloantibodies contribute to neutrophil responses in grafts is not clear…
2018 American Transplant Congress
Chronic Changes on Time Zero Living Donor Allograft Biopsy Portraits Worse Donor Renal Function
A. Nishio-Lucar,¹ J. Murphy,² A. Sites,³ H. Cathro,² A. Doyle,¹ K. Warburton,¹ A. Agarwal.⁴
¹Medicine, University of Virginia, Charlottesville, VA; ²Pathology, University of Virginia, Charlottesville, VA; ³Transplant Services, University of Virginia, Charlottesville, VA; ⁴Surgery, University of Virginia, Charlottesville, VA.
The prognostic ability of zero hour biopsy (ZHB) in renal allografts has not been fully elucidated. ZHB utility predicting living kidney donor (LKD) renal recovery…
2018 American Transplant Congress
Effect of Acute Vascular Inflammation (v) on Death Censored Graft Failure (DCGF) Following Kidney Transplant (KTx)
J. Grande,¹ L. Hunsicker,² R. LeDuc,³ A. Matas, The DeKAF Consortium.
¹Pathology, Mayo Clinic, Rochester, MN; ²Int. Med., U Iowa, Iowa City, IA; ³Biostatistics and Surgery, U Minnesota, Minneapolis, MN.
The impact of acute vascular inflammation in acute cellular or humoral rejection following KTx, and the effect of isolated vascular inflammatory lesions on late DCGF,…
2018 American Transplant Congress
Magnitude of Pre-Biopsy Decline in Renal Function and Its Association with Allograft Rejection
S. Voora,¹ P. Ahearn,¹ M. Tavakol,² K. Johansen,^1,3 E. Ku.¹
¹Division of Nephrology, UCSF, San Francisco, CA; ²Department of Surgery, UCSF, San Francisco, CA; ³Department of Epidemiology/Biostatistics, UCSF, San Francisco, CA.
Introduction: Acute rejection is a significant cause of morbidity, and transplant biopsy remains the gold standard for diagnosing rejection. To our knowledge there have been…
2018 American Transplant Congress
Unilateral vs. Bilateral Dual Kidney Transplantation: University of Bologna Experience
M. Del Gaudio,¹ M. Ravaioli,¹ C. Zanfi,¹ V. Bertuzzo,¹ L. Maroni,¹ G. La Manna,² G. Liviano,² A. Siniscalchi,³ A. D'Errico,⁴ A. Pinna.¹
¹Organ Insufficency and Transplantation/Transplantation Unit Prof. A.D. Pinna, S.Orsola Malpighi Hospital University of Bologna, Bologna, Italy; ²Organ Insufficency and Transplantation Nephrology Unit G. La Manna, S.Orsola Malpighi Hospital University of Bologna, Bologna, Italy; ³Organ Insufficency and Transplantation Intensive Care Unit Prof. S. Faenza, S.Orsola Malpighi Hospital University of Bologna, Bologna, Italy; ⁴Organ Insufficency and Transplantation Pathology Unit D'Errico, S.Orsola Malpighi Hospital University of Bologna, Bolgona, Italy.
One option for using organs from donors with a suboptimal nephron mass, e.g. expanded criteria donors (ECD) kidneys, is dual kidney transplantation (DKT)Methods: Ninety-three DKT…
2018 American Transplant Congress
Factor Analysis (FA) of Renal Transplant Biopsy (KTxBx) Data Enables Objective Assessment of Risk for Subsequent Death Censored Graft Failure (DCGF)
L. Hunsicker,¹ J. Grande,² J. Cecka,³ A. Matas,⁴ The DeKaf Consortium.
¹Int. Med., UIowa, Iowa City, IA; ²Pathology, Mayo Clinic, Rochester, MN; ³Immunogenetics, UCLA, Los Angeles, CA; ⁴Surgery, U Minnesota, Minneapolis, MN.
We examined the impact of five axes of injury identified by FA in the KTxBx on the hazard for subsequent DCGF in two DeKAF cohorts.Methods:…
2018 American Transplant Congress
A Substantial Fraction of Surveillance Transplant Biopsies Have Clinically Actionable Findings
A. Shammout,¹ A. Naik,² M. Samaniego,² E. Farkash.¹
¹Pathology, Michigan Medicine, Ann Arbor; ²Nephrology, Michigan Medicine, Ann Arbor.
Background: Surveillance biopsies in renal transplant recipients may detect subclinical disease that affects graft longevity. At our transplant center, most patients with stable allograft function…
2018 American Transplant Congress
Novel Approach to Molecular Testing Using Routine Diagnostic Tissue
P. Herzyk,¹ F. McMonagle,¹ P. Shiels,¹ S. Coley.²
¹University of Glasgow, Glasgow, United Kingdom; ²Columbia University, New York.
Currently, molecular diagnostics in kidney transplantation requires dedicated fresh tissue. This requirement limits use in mainstream clinical settings due to perceived increased patient risk in…
2018 American Transplant Congress
Predictors of Graft Survival at the Time of a Kidney Transplant Indication Biopsy
G. Einecke,¹ J. Reeve,^2,3 P. Halloran.^2,4
¹Hannover Medical School, Hannover, Germany; ²Alberta Transplant Applied Genomics Centre, Edmonton, Canada; ³Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ⁴Medicine, University of Alberta, Edmonton, Canada.
We predicted kidney transplant graft survival after indication biopsy in 884 patients. Analysis was performed using random forests, a multivariate machine learning method to assess…
2018 American Transplant Congress
Diabetic Nephropathy after Kidney Transplantation in Patients with Pre-Transplantation Type II Diabetes May Occur Later and Be Less Common Than Previously Thought
A. Cimeno, J. Munley, S. Sultan, M. Weir, S. Bartlett, C. Drachenberg, A. Hararian, J. Bromberg, J. Scalea.
Surgery, University of Maryland, Baltimore, MD.
Background: Classical medical teaching suggests that diabetic nephropathy occurs more quickly in transplanted kidneys than in the native kidneys. The largest report of post-transplantation diabetic…