Articles tagged "Biopsy"

2019 American Transplant Congress
Molecular Phenotype of Proliferative Arteriopathy in Kidney Grafts
A. Perkowska-Ptasinska¹, M. Ciszek¹, D. Deborska-Materkowska¹, A. Debska-Slizien², P. F. Halloran³, M. Myslak⁴
¹Warsaw Medical University, Warsaw, Poland, ²Gdansk Medical University, Gdansk, Poland, ³University of Alberta, Edmonton AB, AB, Canada, ⁴Pomeranian Medical University, Szczecin, Poland
*Purpose: Proliferative arteriopathy (PA) is a lesion characterized by a fibrotic tissue in the arterial intima. The phenomenon is marked by the lack of elastic…
2019 American Transplant Congress
Renal Pathological Findings in Living Kidney Donor Candidates with Minimal Urinary Abnormalities
H. Ahmed¹, C. Drachenberg², R. Ugarte¹, N. Costa¹, C. Cangro¹, R. N. Barth³, M. Weir¹, A. Harirain¹
¹Medicine-Nephrology, University of Maryland Medical Center, Baltimore, MD, ²Pathology, University of Maryland Medical Center, Baltimore, MD, ³Surgery, University of Maryland Medical Center, Baltimore, MD
*Purpose: With the increasing number of ESRD patients requiring transplantation and stagnant number of deceased-donor organs available, minimizing the exclusion of living donor candidates with…
2019 American Transplant Congress
Long-term Impact of Antihypertensive Treatment and Tacrolimus Dose in Renal Allograft Recipients 5 Years Post-Transplantation
D. Rush¹, S. Cockfield², S. Wilson³, J. Schwartz⁴
¹University of Manitoba, Winnipeg, MB, Canada, ²University of Alberta Hopspital, Edmonton, AB, Canada, ³Astellas Pharma Global Development, Northbrook, IL, ⁴Astellas Pharma US, Northbrook, IL
*Purpose: Inflammation and fibrosis after renal transplantation may be modulated by optimizing tacrolimus exposure, or by use of angiotensin-converting enzyme inhibitors (ACEi), or angiotensin receptor…
2019 American Transplant Congress
Inflammation and Fibrosis Are Observed in 34% of Clinically Stable Adult Liver Transplant Recipients
L. Sun¹, J. Levitsky², S. Feng³, A. Humar⁴, A. J. Demetris⁴, J. Emond⁵, A. Shaked⁶, G. Klintmalm⁷, K. Mason⁸, M. DesMarais¹, A. Priore⁹, N. Bridges⁹, B. E. Burrell¹⁰, S. Chandran³, J. Markmann¹¹
¹ITN, San Francisco, CA, ²Northwestern, Chicago, IL, ³UCSF, San Francisco, CA, ⁴UPMC, Pittsburg, PA, ⁵Columbia, New York, NY, ⁶UPenn, Philadelphia, PA, ⁷Baylor, Dallas, TX, ⁸Rho, Chapel Hill, NC, ⁹NIAID, Bethesda, MD, ¹⁰ITN, Bethesda, MD, ¹¹MGH, Boston, MA
*Purpose: OPTIMAL is a 7-center immunosuppression withdrawal (ISW) study in non-autoimmune, non-HCV adult liver transplant recipients ≥3 yrs post-transplant (tx) (NCT02533180). Subjects underwent a screening…
2019 American Transplant Congress
Microscopic Hepatic Steatosis Prior to Liver Transplantation Influences Clinical Outcomes
K. Nakamura, H. Hirao, T. Ito, S. Kageyama, K. Kadono, K. J. Dery, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Surgery, Liver Transplant, UCLA, Los Angeles, CA
*Purpose: Although liver transplantation (LT) has become a standard care for end-stage liver diseases, early allograft dysfunction (EAD) and rejection crises curtail the outcomes. Considering…
2019 American Transplant Congress
Analysis of Immune Cell Proportions in Kidney Transplant Biopsies of Acute Cellular Rejection and Antibody Mediated Rejection Compared with Non-Rejecters
C. R. Dorr¹, A. Muthusamy¹, D. P. Schladt¹, W. Guan², B. Wu², J. S. Maltzman³, W. S. Oetting², P. A. Jacobson², A. K. Israni¹
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Stanford University, Palo Alto, CA
*Purpose: Understanding the immune cell types that are associated with acute rejection (AR) in kidney transplant biopsies may lead to new therapeutic targets for AR.…
2019 American Transplant Congress
CD56+CD57+ Infiltrate is a Predominant Subset of Infiltrating Natural Killer Cell in Renal Transplant Biopsies with Antibody-Mediated Rejection
H. Jung¹, Y. Wee², J. Kim², M. Choi², J. Choi², H. Kwon², J. Jung², S. Kim³, Y. Cho⁴, Y. Park⁴, H. Go⁴, M. Han⁵, Y. Kim², D. Han², S. Shin²
¹Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology (AMIST), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ²Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ³Department of Convergence Medicine, Asan Institute for life sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁴Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ⁵Department of Clinical Epidemiology, Asan Medical Center, Seoul, Korea, Republic of
*Purpose: To verify a subset of intragraft and circulating natural killer cells associated with kidney allograft rejection and fibrosis.*Methods: Thirty-nine clinically indicated transplant biopsies performed…
2019 American Transplant Congress
C1q Dominant Deposits in Renal Transplant Biopsies Are Not Associated with Allograft Dysfunction
A. Babu¹, S. Williamson², N. Khoury¹, M. Safwan¹, A. Patel¹
¹Transplant Institute, Henry Ford Hospitals, Detroit, MI, ²Pathology Surgical, Henry Ford Hospitals, Detroit, MI
*Purpose: Complement deposition in renal allograft biopsies and native kidneys may represent an ongoing inflammatory process. We studied the significance of incidental finding of predominant…
2019 American Transplant Congress
When to Hold: Apixaban in Renal Transplant Recipients
V. H. Do¹, D. Haakinson², K. D. Belfield¹
¹Yale New Haven Hospital, New Haven, CT, ²Yale School of Medicine, New Haven, CT
*Purpose: Renal transplant recipients (RTRs) may develop deep venous thrombosis (DVT), pulmonary embolism (PE), or atrial fibrillation requiring treatment with oral anticoagulation. There is limited…
2019 American Transplant Congress
The Influential Yet Highly Variable Role of Biopsy Findings on Kidney Offer Acceptance Decisions: An Organ Offer Simulation Study
D. Stewart¹, J. Rosendale¹, H. McGehee¹, I. Hall², G. Gupta³, K. Reddy⁴, B. Kasiske⁵, K. Andreoni⁶, D. Klassen¹
¹UNOS, Richmond, VA, ²Univ of Utah, Salt Lake City, UT, ³VCU, Richmond, VA, ⁴Mayo, Phoenix, AZ, ⁵HCMC, Minneapolis, MN, ⁶Univ of Florida, Gainesville, FL
*Purpose: The use of procurement biopsies (Bx) to assess kidney quality is controversial. ‘Biopsy findings’ is an often cited discard reason, yet the association between…