ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Biopsy"

  • 2019 American Transplant Congress

    Organ-Procurement Organization and Donor Factor-Related Variation in Deceased Donor Kidney Biopsies and Discards: A National Practice Patterns Analysis

    K. Lentine1, A. Naik2, M. Schnitzler1, H. Randall1, J. Wellen3, B. Kasiske4, G. Marklin5, D. Brockmeier5, M. Cooper6, H. Xiao1, Z. Zhang1, R. Gaston6, R. Rothweiler5, D. Axelrod7

    1Saint Louis Univ, St. Louis, MO, 2Univ of Michigan, Ann Arbor, MI, 3Washington Univ, St. Louis, MO, 4SRTR, Minneapolis, MN, 5Mid-America Transplant, St. Louis, MO, 6Georgetown Univ, Washington, DC, 7Univ of Iowa, Iowa City, IA

    *Purpose: The clinical utility and outcome implications of deceased donor kidney allograft procurement biopsies are controversial.*Methods: We analyzed Scientific Registry of Transplant Recipients data (n=59,328…
  • 2019 American Transplant Congress

    Utility of a Novel dd-cfDNA Test to Detect Injury in Renal Post-Transplant Patients

    J. Peabody1, P. Billings2, Z. Demko2, D. Paculdo1, M. Tran1, S. Moshkevich2, C. Valdenor1

    1QURE Healthcare, San Francisco, CA, 2Natera, Inc., San Carlos, CA

    *Purpose: Detecting allograft injury and rejection is critical to preventing graft loss. Current standard of care (SoC) relies on serum creatinine (SC) and biopsy to…
  • 2019 American Transplant Congress

    Notch1 Signaling Protects Liver Grafts from Ischemia Reperfusion Injury: From Mouse to Human

    K. Kadono, S. Kageyama, H. Hirao, K. Nakamura, T. Ito, K. J. Dery, D. Oncel, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

    Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: The clinical relevance and tissue-specific role of Notch1 activation, a highly conserved transmembrane receptor involved in cell fate decision, proliferation and regeneration, in orthotopic…
  • 2019 American Transplant Congress

    Histologic Ischemia Reperfusion Injury in Liver Transplantation: A Large Single Center Experience

    F. M. Kaldas, T. Ito, S. Younan, J. Aziz, M. Lu, V. G. Agopian, J. DiNorcia III, H. Yersiz, D. G. Farmer, R. W. Busuttil

    Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Ischemia Reperfusion Injury (IRI) is known to adversely affect graft outcomes in Liver Transplantation (LT). Large series examining the significance of IRI found on…
  • 2019 American Transplant Congress

    Outcomes and Clinical Utility of the kSORT Assay in the Prism Prospective Clinical Trial of Highly Sensitized Kidney Transplant Recipients

    A. Schroeder, P. Towfighi, C. Hu, S. Hsieh, J. Liberto, I. Damm, T. Sigdel, P. Millar, M. Sarwal, F. Vincenti

    Department of Surgery, UCSF, San Francisco, CA

    *Purpose: kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of biopsy proven acute rejection (AR) and immune quiescence in kidney transplantation…
  • 2019 American Transplant Congress

    Subtyping Of Histologically Stable Kidney Transplants In Molecular Meta-analysis

    D. Rychkov1, T. Sigdel2, J. Liberto2, M. Sarwal2, M. Sirota3

    1ICHS, Department of Surgery, UCSF, San Francisco, CA, 2Department of Surgery, UCSF, San Francisco, CA, 3ICHS, UCSF, San Francisco, CA

    *Purpose: Histologically stable allografts have been shown to have molecular inflammation by prior gene expression studies. Nevertheless, there are no methodologies in place to sub-group…
  • 2019 American Transplant Congress

    Racial Differences in Acute Kidney Injury Occurrence among Deceased Kidney Donors

    M. Doshi1, I. Hall2, S. Mohan3, C. Liu4, H. Philbrook4, P. Reese5, S. Mansour6, F. Weng7, E. Akalin8, J. Bromberg9, M. Harhay10, T. Muthukumar11, B. Schroeppel12, P. Singh13, C. Parikh4

    1University of Michigan, Ann Arbor, MI, 2University of Utah, Salt Lake City, UT, 3Columbia, New York, NY, 4Johns Hopkins, Baltimore, MD, 5University of Pennsylvania, Philadelphia, PA, 6Yale University, New Haven, CT, 7St. Barnabas, Livingston, NJ, 8Mount Sinai, New York, NY, 9University of Maryland, Baltimore, MD, 10Drexel, Philadelphia, PA, 11Cornell, New York, NY, 12University of Ulm, Ulm, Germany, 13Jefferson, Philadelphia, PA

    *Purpose: Kidneys from African American (AA) deceased donors have lower graft survival than kidneys from white donors, regardless of recipient race. We hypothesized that kidneys…
  • 2019 American Transplant Congress

    Impact of T-cell Mediated Allograft Inflammation within First-Year after Kidney Transplantation: An Analysis of Paired Biopsies from a Single Center Study

    S. Tandukar, R. Mehta, I. Owoyemi, D. Jorgensen, P. Sood, S. Hariharan

    Division of Transplant Nephrology, Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: We evaluated the impact of Clinical and Sub-Clinical T-Cell-Mediated Rejection (TCMR) and Sub-Clinical Inflammation (SCI) within 1 year post-transplant.*Methods: Adult kidney transplant patients who…
  • 2019 American Transplant Congress

    Early Allograft Dysfunction in the Setting of Histologic Ischemia Reperfusion Injury Following Liver Transplantation: Analysis of Predictors and Outcomes

    T. Ito, J. Aziz, V. G. Agopian, S. Younan, J. DiNorcia, H. Yersiz, D. G. Farmer, R. W. Busuttil, F. M. Kaldas

    Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) in Liver Transplantation (LT) is believed to contribute to Early Allograft Dysfunction (EAD). However, the relationship between IRI and EAD…
  • 2019 American Transplant Congress

    Hepatocyte SIRT1 Modulates ATF4/CHOP and Mitigates Liver Transplant Ischemia-Reperfusion Injury: From Bench-to-Bedside

    H. Hirao1, S. Kageyama1, K. Kadono1, K. Nakamura1, T. Ito1, K. J. Dery1, D. Oncel1, X. Li2, B. Ke1, F. M. Kaldas1, R. W. Busuttil1, J. W. Kupiec‐Weglinski1

    1Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, 2National Institute of Environmental Health Sciences, Research Triangle Park, NC

    *Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation against hepatic ischemia-reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Although…
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