ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Biopsy"

  • 2019 American Transplant Congress

    Rapid Detection of Kidney Transplant Injury by Quantifying Donor-Derived Cell-Free Deoxyribonucleic Acid via Massively Multiplex Polymerase Chain Reaction

    T. K. Sigdel1, F. Acosta2, S. Navarro2, B. Zimmermann2, Z. P. Demko2, S. Moshkevich2, P. R. Billings2, M. M. Sarwal1

    1University of California San Francisco, San Francisco, CA, 2Natera Inc., San Carlos, CA

    *Purpose: Plasma donor-derived cell-free DNA (dd-cfDNA) is a proven marker for allograft rejection in patients with kidney transplant (KT). Our goal was to assess performance…
  • 2019 American Transplant Congress

    HuR Dictates HO-1 Expression, Modulates Inflammation and Influences Recipient Outcomes in Liver Transplant Patients

    K. J. Dery, K. Nakamura, K. Kadono, H. Hirao, S. Kageyama, T. Ito, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

    Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: Liver ischemia-reperfusion injury, an innate-immune dominated hepatocellular damage, is a risk factor of early graft dysfunction and rejection in liver transplantation (LT). HuR, an…
  • 2019 American Transplant Congress

    Kidney Grafts Ultrasound Guided Biopsy Performed By Nephrologist. Regaining Technique And Improving Results

    J. Juega, M. Perez, L. Cañas, J. Soler, M. Troya, I. Bancu, R. Lauzurica

    Nephrology, Germans Trias i Pujol Hospital, Badalona, Barcelona, Spain

    *Purpose: Stablish the optimal technique and protocol of ultrasound guided renal graft biopsy to be performed by nephrologist compared with previous standard of care, regading…
  • 2019 American Transplant Congress

    Peritubular Capillary C4d Positivity in Renal Allograft Biopsies: Implications for Allograft Survival

    A. Bailey, S. Tremblay, A. R. Shields, J. Wang, R. Alloway, E. S. Woodle

    Transplant Surgery, University of Cincinnati, Cincinnati, OH

    *Purpose: C4d deposition in the peritubular capillaries (PTCs) is associated with acute antibody mediated rejection (AMR) and reduced renal allograft survival. PTC C4d positivity, however,…
  • 2019 American Transplant Congress

    Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of Kidney Transplant Biopsies

    I. Moinuddin1, D. Kumar1, P. Halloran2, L. Kamal1, A. King1, P. Kimball1, M. Levy1, C. Bhati1, D. Massey1, G. Gupta1

    1VCU Medical Center, Richmond, VA, 2Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Circulating donor-derived cell free DNA (cfDNA; Allosure, CareDx, USA), a non-invasive test that could detect rejection in kidney allografts was validated using histologic diagnoses(HDx).…
  • 2019 American Transplant Congress

    Surveillance Biopsy Utilization Reported Higher In Transplant Centers Performing Over 100 Kidney Transplants Per Year.

    D. M. Lee1, R. First1, S. Rose1, M. Abecassis2

    1Transplant Genomics Inc, Mansfield, MA, 2Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: To assess the frequency of surveillance biopsies in kidney transplant patients in transplant centers performing greater than 100 transplants per year, and to compare…
  • 2019 American Transplant Congress

    Absence of Non Alcoholic Fatty Liver Disease in Allografts from Morbidly Obese Donors: A Marker for Success?

    M. MacConmara, A. Mufti, S. Hanish, T. Kerr, P. Vagefi, C. Hwang

    Surgery (Division of Surgical Transplantation), UT Southwestern, Dallas, TX

    *Purpose: Livers from African-American, morbidly obese donors are less likely to be discarded. We examined the utility of pre-recovery liver biopsy as a predictive biomarker…
  • 2019 American Transplant Congress

    Borderline Changes in Kidney Allografts Represents a Non-Homogenous Cohort with Different Outcome

    P. Hruba1, J. Maluskova1, Z. Krejcik2, M. Merkerova-Dostalova2, V. Stranecky3, J. Klema4, K. Osickova1, M. Wohlfahrtova1, E. Honsova1, O. Viklicky1

    1Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Institute of Hematology and Blood Transfusion, Prague, Czech Republic, 3Institute of Inherited Metabolic Disorders, Prague, Czech Republic, 4Czech Technical University, Prague, Czech Republic

    *Purpose: Borderline changes (BL) represent a frequent histological finding in kidney allograft with unclear prognosis.*Methods: In this single center, retrospective, observational study, the BL were…
  • 2019 American Transplant Congress

    Is HLA Donor-Specific Antibody (DSA)-C3d+ Assay a Potential Predictor of Subclinical Antibody Mediated Damage in the Renal Graft?

    A. G. Contreras1, M. I. Solis-G1, C. Ramirez-Espinoza1, J. Hernandez-Rosales2, M. Vilatoba-Chapa1, R. Cruz-Martínez1, J. Granados1, L. E. Morales-Buenrostro3, J. Alberú1, J. M. Arreola-Guerra4

    1Transplantation, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, 2Department of Histocompatibility, Laboratorio Clinico del Campestre, Mexico City, Mexico, 3Nephrology-Mineral Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, 4Internal Medicine, Centenario Hospital Miguel Hidalgo, Mexico City, Mexico

    *Purpose: The Aim of the study was to explore the predictive value of the C3d assay for tissue damage in kidney transplant recipients (KTR) in…
  • 2019 American Transplant Congress

    Single Cell Sequencing of Human Kidney Allograft

    H. Yang1, H. Suryawanshi2, M. Lagman1, M. Lubetzky1, A. Alonso1, S. Seshan1, T. Tuschl2, M. Suthanthiran1, T. Muthukumar1

    1Weill Cornell Medicine, New York, NY, 2Rockefeller University, New York, NY

    *Purpose: Transcriptome-based clustering of individual cells within the kidney allograft may help identify cell type-specific injury and has the potential to redefine the current histopathology-based…
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