Articles tagged "Biopsy"

2019 American Transplant Congress
Molecular Analysis of Rejection and Injury in Human Liver Transplant Biopsies: First Results of the INTERLIVER Study
P. F. Halloran and The INTERLIVER Study Group
University of Alberta, Edmonton AB, AB, Canada
*Purpose: The relationship of histologic liver transplant biopsy assessments to actual rejection and injury is unclear. Recent progress in molecular reclassification of kidney, heart, and…
2019 American Transplant Congress
Clinical Implications of Serum Mac-2 Binding Protein in Regular Follow Up after Pediatric Living Donor Liver Transplantation
T. Ueno¹, T. Kodama¹, Y. Noguchi¹, M. Nomura¹, R. Saka¹, Y. Takama¹, Y. Tazuke¹, K. Bessho², H. Okuyama¹
¹Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan, ²Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan
*Purpose: Pediatric living donor liver transplant (LDLT) patients sometimes develops graft fibrosis. They showed graft fibrosis even if their liver function tests were within normal…
2019 American Transplant Congress
Proteomics Reveals Molecular Window and Metabolism of Normothermically Perfused Human Kidneys
A. Weissenbacher¹, H. Huang², A. Thorne³, L. M. Lo Faro³, J. Hunter³, R. Ploeg³, C. C. Coussios⁴, P. J. Friend³, B. Kessler⁵
¹Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, ²Nuffield Department o Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom, ³Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ⁴Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ⁵Nuffield Department o Medicine, Target Discovery Instituteiscovery Institute, University of Oxford, Oxford, United Kingdom
*Purpose: We have shown that 24h normothermic kidney perfusion (NKP) with urine recirculation (URC) is superior to non URC for maintaining homeostasis previously. However, the…
2019 American Transplant Congress
Racial Differences in Acute Kidney Injury Occurrence among Deceased Kidney Donors
M. Doshi¹, I. Hall², S. Mohan³, C. Liu⁴, H. Philbrook⁴, P. Reese⁵, S. Mansour⁶, F. Weng⁷, E. Akalin⁸, J. Bromberg⁹, M. Harhay¹⁰, T. Muthukumar¹¹, B. Schroeppel¹², P. Singh¹³, C. Parikh⁴
¹University of Michigan, Ann Arbor, MI, ²University of Utah, Salt Lake City, UT, ³Columbia, New York, NY, ⁴Johns Hopkins, Baltimore, MD, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Yale University, New Haven, CT, ⁷St. Barnabas, Livingston, NJ, ⁸Mount Sinai, New York, NY, ⁹University of Maryland, Baltimore, MD, ¹⁰Drexel, Philadelphia, PA, ¹¹Cornell, New York, NY, ¹²University of Ulm, Ulm, Germany, ¹³Jefferson, Philadelphia, PA
*Purpose: Kidneys from African American (AA) deceased donors have lower graft survival than kidneys from white donors, regardless of recipient race. We hypothesized that kidneys…
2019 American Transplant Congress
Impact of T-cell Mediated Allograft Inflammation within First-Year after Kidney Transplantation: An Analysis of Paired Biopsies from a Single Center Study
S. Tandukar, R. Mehta, I. Owoyemi, D. Jorgensen, P. Sood, S. Hariharan
Division of Transplant Nephrology, Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: We evaluated the impact of Clinical and Sub-Clinical T-Cell-Mediated Rejection (TCMR) and Sub-Clinical Inflammation (SCI) within 1 year post-transplant.*Methods: Adult kidney transplant patients who…
2019 American Transplant Congress
Early Allograft Dysfunction in the Setting of Histologic Ischemia Reperfusion Injury Following Liver Transplantation: Analysis of Predictors and Outcomes
T. Ito, J. Aziz, V. G. Agopian, S. Younan, J. DiNorcia, H. Yersiz, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI) in Liver Transplantation (LT) is believed to contribute to Early Allograft Dysfunction (EAD). However, the relationship between IRI and EAD…
2019 American Transplant Congress
Histologic Ischemia Reperfusion Injury in Liver Transplantation: A Large Single Center Experience
F. M. Kaldas, T. Ito, S. Younan, J. Aziz, M. Lu, V. G. Agopian, J. DiNorcia III, H. Yersiz, D. G. Farmer, R. W. Busuttil
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Ischemia Reperfusion Injury (IRI) is known to adversely affect graft outcomes in Liver Transplantation (LT). Large series examining the significance of IRI found on…
2019 American Transplant Congress
Outcomes and Clinical Utility of the kSORT Assay in the Prism Prospective Clinical Trial of Highly Sensitized Kidney Transplant Recipients
A. Schroeder, P. Towfighi, C. Hu, S. Hsieh, J. Liberto, I. Damm, T. Sigdel, P. Millar, M. Sarwal, F. Vincenti
Department of Surgery, UCSF, San Francisco, CA
*Purpose: kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of biopsy proven acute rejection (AR) and immune quiescence in kidney transplantation…
2019 American Transplant Congress
Subtyping Of Histologically Stable Kidney Transplants In Molecular Meta-analysis
D. Rychkov¹, T. Sigdel², J. Liberto², M. Sarwal², M. Sirota³
¹ICHS, Department of Surgery, UCSF, San Francisco, CA, ²Department of Surgery, UCSF, San Francisco, CA, ³ICHS, UCSF, San Francisco, CA
*Purpose: Histologically stable allografts have been shown to have molecular inflammation by prior gene expression studies. Nevertheless, there are no methodologies in place to sub-group…
2019 American Transplant Congress
Evaluation of Pretransplant Biopsy as a Influence Factor of Early Graft Function after Donated Kidney Transplantation
X. Qiuxiang, W. Zhendi
Urology Surgery, Wuhan Union Hospital, Wuhan, China
*Purpose: To investigate the relationship between pretransplant biopsy and the early graft function after donated kidney transplantation.*Methods: We examined pretransplant biopsies for 240 kidney transplant…