Articles tagged "Biopsy"

2019 American Transplant Congress
CEACAM1 – p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human
H. Hirao¹, K. Nakamura¹, S. Kageyama¹, T. Ito¹, K. Kadono¹, M. Kujawski², K. J. Dery¹, R. A. Sosa¹, E. F. Reed¹, F. M. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec‐Weglinski¹
¹UCLA, Los Angeles, CA, ²City of Hope, Duarte, CA
*Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolism, its role in orthotopic liver transplantation (OLT) is unknown. A recent…
2019 American Transplant Congress
Quantitative Proteome Profiling in T Cell-Mediated Rejection
L. Song¹, G. Zeng², P. Liu³, F. Fang⁴, H. Liu⁴, X. Xie¹, P. Randhawa², K. Xiao⁴
¹Department of Urological Organ Transplantation, The Second Xiangya Hospital, Central-South University, Changsha, China, ²Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Department of Biostatistics, Graduate School of Public Health, and Departments of Pharmacology and P, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA
*Purpose: The proteomic analyses through formalin-fixation and paraffin embedding (FFPE) specimens reflects systemic and inherent renal injury perturbations for different kidney transplant injury states. In…
2019 American Transplant Congress
Increased Number of Intragraft FoxP3+ T Cells is Strongly Correlated with Decreased Graft Survival in Chronic Active Antibody Mediated Rejection
K. Sablik¹, K. Jordanova², M. Clahsen-van Groningen¹, M. Betjes¹
¹Erasmus MC, Rotterdam, Netherlands, ²Amsterdam UMC, Amsterdam, Netherlands
*Purpose: Chronic-active antibody-mediated rejection (c-aABMR) is the most important cause of late renal allograft failure. However, renal inflammation and rate of loss of renal allograft…
2019 American Transplant Congress
Ikaros/IRF4 Signaling Regulates SIRT1-Mediated Macrophage M2 Shift in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human
K. Kadono¹, K. Nakamura¹, H. Hirao¹, S. Kageyama¹, K. J. Dery¹, T. Ito¹, J. Aziz¹, X. Li², B. Ke¹, R. W. Busuttil¹, J. W. Kupiec‐Weglinski¹
¹Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and rejection in liver transplantation (LT). Despite the efficacy of Sirtuin 1…
2019 American Transplant Congress
Are Protocol Biopsies Necessary for Pediatric Renal Transplant Recipients?
E. Allred, E. Ingulli
Pediatrics, UCSD, San Diego, CA
*Purpose: Renal allograft survival indirectly correlates with acute rejection episodes. Subacute rejection is also associated with decreased graft survival. Protocol biopsies (bxs) have been implemented…
2019 American Transplant Congress
Recipient Antibiotics Pretreatment Protects Liver Transplants from Ischemia-Reperfusion Injury via Prostaglandin E2: From Bench-to Bedside
K. Nakamura, S. Kageyama, T. Ito, H. Hirao, K. Kadono, K. J. Dery, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation and autophagy enhancement to mitigate ischemia-reperfusion injury (IRI) in orthotopic liver…
2019 American Transplant Congress
Timing and Donor-Specific Antibodies, but Not C4d Deposition, Determine Leukocyte Infiltration in Renal Allograft Biopsies with the Histological Picture of Antibody-Mediated Rejection
J. Callemeyn¹, A. Senev¹, E. Lerut², M. Coemans¹, D. Kuypers¹, W. Gwinner³, M. Essig⁴, D. Anglicheau⁵, P. Marquet⁶, M. Naesens¹
¹Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, ²Department of Pathology, University Hospitals Leuven, Leuven, Belgium, ³Department of Nephrology, Hannover Medical School, Hannover, Germany, ⁴Department of Nephrology, Dialysis and Transplantation, University of Limoges, Limoges, France, ⁵Necker-Enfants Malades Institute, French National Institute of Health and Medical Research U1151, Paris, France, ⁶U850 INSERM, University of Limoges, Limoges, France
*Purpose: Diagnosis of antibody-mediated rejection following kidney transplantation can be challenging, given the limited specificity of individual histological parameters and time-dependent occurrence of histological confounders.…
2019 American Transplant Congress
Incidence and Predictors of Post-Kidney Biopsy (KBx) Bleeding in Liver Transplant (LT) Candidates with Renal Dysfunction
H. M. Wadei¹, P. Abader¹, N. Aslam², T. Jarmi¹, A. P. Keaveny¹, K. Croome¹, D. D. Lee¹, C. Taner¹
¹Department of Transplant, Mayo Clinic, Jacksonville, FL, ²Department of Medicine, Division of Nephrology, Mayo Clinic, Jacksonville, FL
*Purpose: Pre-LT kidney biopsy is seldom performed in LT candidates with renal dysfunction and/or proteinuria partially due to the limited information regarding KBx bleeding. We…
2019 American Transplant Congress
Recipient TIM4 Expression is Essential for Hepatocellular Function in Liver Transplantation
K. Kadono, S. Kageyama, H. Hirao, K. Nakamura, K. J. Dery, D. Oncel, T. Ito, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and predisposes to rejection in orthotopic liver transplantation (OLT). Previous studies…
2019 American Transplant Congress
Microsteatosis in Livers from Donation after Circulatory Death (DCD) Donors is Associated with Inferior Graft and Patient Survival Following Liver Transplantation (LTX)
N. Bath, G. Leverson, D. Foley
University of Wisconsin, Madison, WI
*Purpose: The current theory is that severe macrosteatosis (MaS) (>50%) in livers recovered from donation after brain death (DBD) donors leads to increased rates of…