Articles tagged "Biopsy"

2019 American Transplant Congress
High Prevalence of De Novo Donor-Specific Antibodies during Rejection after Liver Transplantation
J. Colmenero, N. Flores, A. Diaz, M. Vasquez, P. Ruiz, G. Crespo, J. Martorell, M. Navasa
Liver Transplant Unit, Hospital Clinic Barcelona, Barcelona, Spain
*Purpose: Anti-HLA donor specific antibodies (dnDSA) after liver transplantation (LT) are currently under investigation. Recent studies show an incidence of dnDSA after LT ranging from…
2019 American Transplant Congress
The Safety of Surveillance and Indication Biopsies in Kidney Transplantation: A Series of 2000 Biopsies
A. S. Naik¹, Y. Huang², D. M. Cibrik³, E. Shaban¹, M. McGuire¹, C. Boyer¹, S. P. Norman¹
¹Internal Medicine/Nephrology, Univ of Michigan Medical Ctr, Ann Arbor, MI, ²Internal Medicine/Nephrology, Univ of California Davis, Sacremento, CA, ³Internal Medicine/Nephrology, Kansas University Medical Center, Kansas City, KS
*Purpose: Kidney biopsy (KB) remains the most important diagnostic tool in kidney transplantation. Despite its value, surveillance KB are not routinely done at majority of…
2019 American Transplant Congress
A Potential Role for IgE-Mediated Immune Response in the Pathogenesis of Chronic Antibody-Mediated Rejection
F. Rascio¹, P. Pontrelli², G. S. Netti³, E. Manno¹, B. Infante¹, S. Simone², G. Castellano², M. Seveso⁴, E. Cozzi⁴, L. Gesualdo², G. Stallone¹, G. Grandaliano¹
¹Department of Medical and Surgical Sciences, Nephrology Dialysis and Transplantation Unit, University of Foggia, Foggia, Italy, ²Department of Emergency, and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy, ³Dept. of Medical and Surgical Sciences, Clinical Pathology Unit, University of Foggia, Foggia, Italy, ⁴Department of Cardiac, Thoracic and Vascular Sciences, Transplant Immunology Unit, University of Padua, Padova, Italy
*Purpose: Chronic antibody-mediated rejection (CAMR) is the main cause of graft loss and shares with systemic lupus erythematosus (SLE) the antibody-mediated kidney damage and the…
2019 American Transplant Congress
Liquid Biopsy for Chronic Rejection after Kidney Transplantation. A Novel Non-Invasive Biomarker Involved in Inflammatory Amplifier
Y. Takada¹, D. Kamimura², H. Higuchi¹, D. Iwami¹, K. Hotta¹, N. Iwahara¹, N. Shinohara¹, M. Murakami²
¹Renal and Genitourinary Surgery, Hokkaido University Hospital, Sapporo, Japan, ²Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
*Purpose: In kidney transplantation (KTx), despite recent advances of medical technology, chronic rejection accounts for 25% of the graft loss. Chronic active antibody-mediated rejection (CAAMR)…
2019 American Transplant Congress
Kidney Donor Profile Index Significantly Correlates With Reperfusion Biopsy Findings
A. Perez-Gutierrez¹, P. Witkowski¹, J. Fung¹, D. N. Danz², R. Cummings¹, A. Chang³
¹Transplantation Institute, University of Chicago Medicine, Chicago, IL, ²Economics, University of Pittsburgh, Pittsburgh, PA, ³Pathology, University of Chicago Medicine, Chicago, IL
*Purpose: The kidney donor profile index (KDPI) includes donor factors that are associated with graft survival, and estimates the quality of the kidney graft. Suboptimal…
2019 American Transplant Congress
Role of Molecular Microscope in the Interpretation of Endarteritis and Acute Thrombotic Microangiopathy
M. Ciszek¹, A. Perkowska-Ptasińska¹, D. Deborska-Materkowska¹, A. Debska-Slizien², P. F. Halloran³, M. Myslak⁴
¹Warsaw Medical Univeristy, Warsaw, Poland, ²Gdansk Medical University, Gdansk, Poland, ³ATAGC, University of Alberta, Edmonton AB, AB, Canada, ⁴Pomeranian Medical University, Szczecin, Poland
*Purpose: According to the Banff classification, endarteritis (Figure 1A, case 1) may be a manifestation of either: TCMR and ABMR. Acute thrombotic microangiopathy (TMA) constitutes…
2019 American Transplant Congress
CD4 T Cell is Essential in an Innate-Immune Driven Ischemia-Reperfusion Injury in Mouse and Human
S. Kageyama¹, K. Kadono¹, H. Hirao¹, K. Nakamura¹, T. Ito², K. J. Dery¹, D. Oncel¹, R. A. Sosa³, E. F. Reed³, F. M. Kaldas², R. W. Busuttil², J. W. Kupiec-Weglinski¹, Y. Zhai¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, ³Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA
*Purpose: Although CD4 T cells are critical in the mechanism of allograft rejection, little is known about their role in the innate immune-driven ischemia-reperfusion injury…
2019 American Transplant Congress
Molecular Analysis of Rejection and Injury in Human Liver Transplant Biopsies: First Results of the INTERLIVER Study
P. F. Halloran and The INTERLIVER Study Group
University of Alberta, Edmonton AB, AB, Canada
*Purpose: The relationship of histologic liver transplant biopsy assessments to actual rejection and injury is unclear. Recent progress in molecular reclassification of kidney, heart, and…
2019 American Transplant Congress
Clinical Implications of Serum Mac-2 Binding Protein in Regular Follow Up after Pediatric Living Donor Liver Transplantation
T. Ueno¹, T. Kodama¹, Y. Noguchi¹, M. Nomura¹, R. Saka¹, Y. Takama¹, Y. Tazuke¹, K. Bessho², H. Okuyama¹
¹Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan, ²Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan
*Purpose: Pediatric living donor liver transplant (LDLT) patients sometimes develops graft fibrosis. They showed graft fibrosis even if their liver function tests were within normal…
2019 American Transplant Congress
Proteomics Reveals Molecular Window and Metabolism of Normothermically Perfused Human Kidneys
A. Weissenbacher¹, H. Huang², A. Thorne³, L. M. Lo Faro³, J. Hunter³, R. Ploeg³, C. C. Coussios⁴, P. J. Friend³, B. Kessler⁵
¹Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, ²Nuffield Department o Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom, ³Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ⁴Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ⁵Nuffield Department o Medicine, Target Discovery Instituteiscovery Institute, University of Oxford, Oxford, United Kingdom
*Purpose: We have shown that 24h normothermic kidney perfusion (NKP) with urine recirculation (URC) is superior to non URC for maintaining homeostasis previously. However, the…