Articles tagged "Biopsy"

2019 American Transplant Congress
Graft TIM4 Deficiency Protects Liver from Ischemia Reperfusion Injury: From Mouse to Human
S. Kageyama¹, K. Kadono¹, H. Hirao¹, K. Nakamura¹, T. Ito², K. J. Dery¹, D. Oncel¹, B. Ke¹, F. M. Kaldas², R. W. Busuttil², J. W. Kupiec-Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA
*Purpose: Liver ischemia-reperfusion injury (IRI) is a major risk factor for early graft dysfunction and rejection in orthotopic liver transplantation (OLT). We and others have…
2019 American Transplant Congress
Urinary Podocin mRNA as Predictor of Renal Allograft Function Decline
A. Naik¹, J. Aqeel¹, D. Cibrik², M. Samaniego³, L. Wickman¹, S. Wang¹, M. Chowdhury¹, R. Wiggins¹
¹University of Michigan, Ann Arbor, MI, ²University of Kansas, Kansas City, KS, ³Henry Ford, Detroit, MI
*Purpose: Traditional biomarkers (such as proteinuria, 1year eGFR) as well as validated risk prediction tools such as the Birmingham Risk Score predict risk of ESRD.…
2019 American Transplant Congress
Clinical Outcomes and Risk Factors for Delayed or Slow Graft Function in an Adult, Urban Renal Transplant Population
K. Tejani, Z. Hajjiri, E. Benedetti, A. Lichvar
University of Illinois at Chicago, Chicago, IL
*Purpose: Delayed graft function (DGF) and slow graft function (SGF) are shown to be associated with higher risk of rejection and suboptimal allograft function over…
2019 American Transplant Congress
International Multicenter Study Evaluating Clinical Outcomes Associated with Acute Antibody-Mediated Rejection
S. Corman¹, I. Hirji², E. Brouwer², S. H. Park¹, C. Macahilig³, A. Vergani², T. Bo², P. Wolthoff³, P. Keown⁴
¹Pharmerit International, Bethesda, MD, ²Shire, Cambridge, MA, ³Medical Data Analytics, Parsippany, NJ, ⁴University of British Columbia, Vancouver, BC, Canada
*Purpose: Evaluating factors that impact clinical outcomes of patients with acute antibody-mediated rejection (aAMR) may help manage and improve outcomes following kidney transplant. The objective…
2019 American Transplant Congress
The Changing Face of T Cell-Mediated Rejection
A. Perkowska-Ptasinska and INTERCOMEX investigators¹, P. F. Halloran²
¹Medical University of Warsaw, Warsaw, Poland, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: We studied how the problem of TCMR in indication biopsies was changing with time by exploring features of 138 biopsies with molecular TCMR in…
2019 American Transplant Congress
The Polish Troubled Kidney Transplant Biopsy Study: External Validation of the Molecular Microscope System
M. Myślak¹, D. Deborska-Materkowska², M. Ciszek², J. Mazurkiewicz¹, A. Debska-Slizien³, P. F. Halloran⁴, A. Perkowska-Ptasińska⁵
¹Pomeranian Medical University, Szczecin, Poland, ²Warsaw Medical Univeristy, Warsaw, Poland, ³Gdansk Medical University, Gdansk, Poland, ⁴Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, ⁵Medical University of Warsaw, Warsaw, Poland
*Purpose: The transplant clinician frequently encounters kidney transplant biopsies that are difficult to interpret by histology. A Molecular Microscope Diagnostic System (MMDx) has been developed…
2019 American Transplant Congress
Urinary Extracellular Vesicles-Related Protein Biomarkers for the Non-Invasive Monitoring of Rejection in Kidney Transplanted Patients
L. Carreras-Planella¹, I. Bancu², D. Cucchiari³, L. Cañas², J. Juega², M. Franquesa¹, M. Perez-Mir², I. Revuelta³, F. Diekman⁴, R. Lauzurica², F. Borràs¹
¹REMAR-IVECAT Group, Institut Germans Trias i Pujol, Badalona, Spain, ²Nephrology- Renal Transplant Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ³Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Barcelona, Spain, ⁴Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Badalona, Spain
*Purpose: Chronic kidney rejection is currently the main cause of graft losses. Blood and urine analyses to monitor kidney transplanted patients are not specific, and…
2019 American Transplant Congress
Clinicopathologic Assessment of Monoclonal Immunoglobulin (Ig) Associated Renal Disease in the Kidney Allograft
J. Kamal¹, R. J. Crew¹, X. Ye², J. Swanson³, G. Appel¹, G. Markowitz⁴, V. D'Agati⁴, I. Batal⁴
¹Nephrology, Columbia Unversity Medical Center, NEW YORK, NY, ²Nephrology, Hartford Hospital, Hartford, CT, ³Surgery, Christiana Hospital, Newark, DE, ⁴Pathology, Columbia Unversity Medical Center, NEW YORK, NY
*Purpose: Monoclonal (M)Ig-associated renal disease comprises a group of disorders caused by paraproteins. Little is known about this entity in the renal allograft, as it…
2019 American Transplant Congress
Do Outcomes Differ in Glomerulitis Predominant Antibody Mediated Rejection and Peritubular capillaritis Predominant Antibody Mediated Rejection?
S. Sethi¹, J. Hou², M. Lin², Y. Ren², A. Peng¹, R. Najjar¹, A. Vo¹, S. Jordan¹, M. Haas², E. Huang¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA, ²Pathology, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: The diagnosis of antibody-mediated rejection (ABMR) in renal allografts requires microvascular inflammation in the form of glomerulitis or peritubular capillaritis (g>0 and/or ptc>0). We…
2019 American Transplant Congress
Chronic Changes on Time Zero Living Donor Allograft Biopsy Do Not Portend Future Kidney Function
A. Agarwal¹, A. Sites², K. L. Brayman¹, A. Doyle³, J. Oberholzer¹, A. Nishio-Lucar³
¹Surgery, University of Virginia, Charlottesville, VA, ²Transplant, University of Virginia, Charlottesville, VA, ³Medicine, University of Virginia, Charlottesville, VA
*Purpose: The predictive ability of implantation biopsies of kidney allografts on either future recipient or living donor kidney function has not been fully elucidated. Herein,…