Articles tagged "Biopsy"

2019 American Transplant Congress
The Changing Face of T Cell-Mediated Rejection
A. Perkowska-Ptasinska and INTERCOMEX investigators¹, P. F. Halloran²
¹Medical University of Warsaw, Warsaw, Poland, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: We studied how the problem of TCMR in indication biopsies was changing with time by exploring features of 138 biopsies with molecular TCMR in…
2019 American Transplant Congress
The Polish Troubled Kidney Transplant Biopsy Study: External Validation of the Molecular Microscope System
M. Myślak¹, D. Deborska-Materkowska², M. Ciszek², J. Mazurkiewicz¹, A. Debska-Slizien³, P. F. Halloran⁴, A. Perkowska-Ptasińska⁵
¹Pomeranian Medical University, Szczecin, Poland, ²Warsaw Medical Univeristy, Warsaw, Poland, ³Gdansk Medical University, Gdansk, Poland, ⁴Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, ⁵Medical University of Warsaw, Warsaw, Poland
*Purpose: The transplant clinician frequently encounters kidney transplant biopsies that are difficult to interpret by histology. A Molecular Microscope Diagnostic System (MMDx) has been developed…
2019 American Transplant Congress
Urinary Extracellular Vesicles-Related Protein Biomarkers for the Non-Invasive Monitoring of Rejection in Kidney Transplanted Patients
L. Carreras-Planella¹, I. Bancu², D. Cucchiari³, L. Cañas², J. Juega², M. Franquesa¹, M. Perez-Mir², I. Revuelta³, F. Diekman⁴, R. Lauzurica², F. Borràs¹
¹REMAR-IVECAT Group, Institut Germans Trias i Pujol, Badalona, Spain, ²Nephrology- Renal Transplant Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ³Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Barcelona, Spain, ⁴Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Badalona, Spain
*Purpose: Chronic kidney rejection is currently the main cause of graft losses. Blood and urine analyses to monitor kidney transplanted patients are not specific, and…
2019 American Transplant Congress
Clinicopathologic Assessment of Monoclonal Immunoglobulin (Ig) Associated Renal Disease in the Kidney Allograft
J. Kamal¹, R. J. Crew¹, X. Ye², J. Swanson³, G. Appel¹, G. Markowitz⁴, V. D'Agati⁴, I. Batal⁴
¹Nephrology, Columbia Unversity Medical Center, NEW YORK, NY, ²Nephrology, Hartford Hospital, Hartford, CT, ³Surgery, Christiana Hospital, Newark, DE, ⁴Pathology, Columbia Unversity Medical Center, NEW YORK, NY
*Purpose: Monoclonal (M)Ig-associated renal disease comprises a group of disorders caused by paraproteins. Little is known about this entity in the renal allograft, as it…
2019 American Transplant Congress
Do Outcomes Differ in Glomerulitis Predominant Antibody Mediated Rejection and Peritubular capillaritis Predominant Antibody Mediated Rejection?
S. Sethi¹, J. Hou², M. Lin², Y. Ren², A. Peng¹, R. Najjar¹, A. Vo¹, S. Jordan¹, M. Haas², E. Huang¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA, ²Pathology, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: The diagnosis of antibody-mediated rejection (ABMR) in renal allografts requires microvascular inflammation in the form of glomerulitis or peritubular capillaritis (g>0 and/or ptc>0). We…
2019 American Transplant Congress
Chronic Changes on Time Zero Living Donor Allograft Biopsy Do Not Portend Future Kidney Function
A. Agarwal¹, A. Sites², K. L. Brayman¹, A. Doyle³, J. Oberholzer¹, A. Nishio-Lucar³
¹Surgery, University of Virginia, Charlottesville, VA, ²Transplant, University of Virginia, Charlottesville, VA, ³Medicine, University of Virginia, Charlottesville, VA
*Purpose: The predictive ability of implantation biopsies of kidney allografts on either future recipient or living donor kidney function has not been fully elucidated. Herein,…
2019 American Transplant Congress
Rapid Detection of Kidney Transplant Injury by Quantifying Donor-Derived Cell-Free Deoxyribonucleic Acid via Massively Multiplex Polymerase Chain Reaction
T. K. Sigdel¹, F. Acosta², S. Navarro², B. Zimmermann², Z. P. Demko², S. Moshkevich², P. R. Billings², M. M. Sarwal¹
¹University of California San Francisco, San Francisco, CA, ²Natera Inc., San Carlos, CA
*Purpose: Plasma donor-derived cell-free DNA (dd-cfDNA) is a proven marker for allograft rejection in patients with kidney transplant (KT). Our goal was to assess performance…
2019 American Transplant Congress
HuR Dictates HO-1 Expression, Modulates Inflammation and Influences Recipient Outcomes in Liver Transplant Patients
K. J. Dery, K. Nakamura, K. Kadono, H. Hirao, S. Kageyama, T. Ito, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Liver ischemia-reperfusion injury, an innate-immune dominated hepatocellular damage, is a risk factor of early graft dysfunction and rejection in liver transplantation (LT). HuR, an…
2019 American Transplant Congress
Kidney Grafts Ultrasound Guided Biopsy Performed By Nephrologist. Regaining Technique And Improving Results
J. Juega, M. Perez, L. Cañas, J. Soler, M. Troya, I. Bancu, R. Lauzurica
Nephrology, Germans Trias i Pujol Hospital, Badalona, Barcelona, Spain
*Purpose: Stablish the optimal technique and protocol of ultrasound guided renal graft biopsy to be performed by nephrologist compared with previous standard of care, regading…
2019 American Transplant Congress
Peritubular Capillary C4d Positivity in Renal Allograft Biopsies: Implications for Allograft Survival
A. Bailey, S. Tremblay, A. R. Shields, J. Wang, R. Alloway, E. S. Woodle
Transplant Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: C4d deposition in the peritubular capillaries (PTCs) is associated with acute antibody mediated rejection (AMR) and reduced renal allograft survival. PTC C4d positivity, however,…