Articles tagged "Biopsy"

2022 American Transplant Congress
Deep-Learning Based Pathological Assessment of Frozen Procurement Kidney Biopsies
Z. Yi¹, C. Xi¹, M. Menon², P. Cravedi¹, B. Murphy¹, S. Ward¹, F. Salem¹, W. Zhang¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Yale University School of Medicine, New York, NY
*Purpose: Organ shortage in kidney transplantation is a major issue for ESKD individuals on the waiting list. Sclerotic glomeruli or interstitial fibrosis on procurement donor…
2022 American Transplant Congress
Histologic Borderline Reflects Molecular Injury Not Rejection: Results from the Trifecta Study
P. F. Halloran¹, K. S. Madill-Thomsen¹, Z. Demko², A. Prewett², P. Billings², P. Gauthier², .. and the Trifecta Investigators³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Natera Inc., San Carlos, CA, ³., ., AB, Canada
*Purpose: In the Trifecta study (NCT04239703), we recently compared indication biopsy diagnoses (MMDx and histology) and plasma %dd-cfDNA levels for indication biopsies (JASN in press…
2022 American Transplant Congress
Reassessment of Previous Kidney Discards from a Single Large Organ Procurement Organization
S. Bunnapradist¹, T. Seto², A. Cohen², T. Rosenthal¹, G. Danovitch¹
¹David Geffen School of Medicine, Los Angeles, CA, ²One Legacy, Los Angeles, CA
*Purpose: After deceased donor kidneys are recovered, they are offered according to UNOS policy and are discarded if no centers in the country would use…
2022 American Transplant Congress
The Relative Association of Clinical Variables and Histologic Lesions with Molecular Rejection in Kidney Transplant Biopsies
M. L. Sikosana¹, J. Reeve², P. F. Halloran², INTERCOMEX Investigators³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³INTERCOMEX, Edmonton, AB, Canada
*Purpose: Availability of molecular assessment (MMDx) independent of conventional variables (time, clinical, histologic, and HLA antibody) presents an opportunity to re-assess the relative strength of…
2022 American Transplant Congress
The Ontario Anatomic Kidney Score (OAKS) : Quantitative Macroscopic Assessment versus Histological Grading in Pre-transplant Evaluation of Donor Kidneys
J. Mello Offerni¹, D. Matty², H. Abed³, P. Roshanov⁴, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Undergraduate Medical Education, Western University, Schulich School of Medicine & Dentistry, London, ON, Canada, ³Division of Urology, Department of Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ⁴Division of Nephrology, Department of Internal Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada
*Purpose: Quantitative gross assessment of a kidney has not been used to influence the evaluation to utilize a kidney for transplantation. The Ontario Anatomic Kidney…
2022 American Transplant Congress
Treading the Paradigm Shift: A Single Center Comparative Study of Outcomes Between Pre-Emptive and Early Kidney Transplant with Non Pre-Emptive Kidney Transplant Recipients Innational Kidney and Transplant Institute
E. U. Go, L. Baloloy
Organ Transplantation and Vascular Surgery, National Kidney and Transplant Institute, Quezon City, Philippines
*Purpose: To compare the 3-year outcome of pre-emptive and early kidney transplant recipients versus non pre-emptive recipients in our institution from January 2013 to December…
2022 American Transplant Congress
Biopsy Characteristics of Kidneys from a Single Large OPO
S. Bunnapradist¹, T. Seto², A. Cohen², T. Rosenthal¹, G. Danovitch¹
¹David Geffen School of Medicine, Los Angeles, CA, ²One Legacy, Los Angeles, CA
*Purpose: As deceased donor pool have expanded, kidney biopsy has been increasingly used to help determine organ suitability for transplant. There are concerns that biopsy…
2022 American Transplant Congress
Top Molecules Associated with CLAD in Lung Transplants Are Shared Between Mucosal Biopsies, Transbronchial Biopsies, and Kidney Transplant Biopsies at Risk of Progression
M. Mackova¹, K. Halloran², P. F. Halloran¹, .. and the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) is a physiologic state with grave consequences for progression to failure but cannot be diagnosed by biopsy histology. We…
2022 American Transplant Congress
Prospective Study of Preimplantation Biopsy in Deceased Donor Kidney Transplantation (DDKT)
H. Me, M. Smith, C. Jadlowiec, K. Harris, R. Butterfield, H. Khamash, B. G. AbuJawdeh, K. Reddy, R. Heilman
Mayo Clinic, Phoenix, AZ
*Purpose: Our aim was to study the impact of preimplantation biopsy (Bx) findings in selecting kidneys from more marginal donors.*Methods: This is a 2-year prospective…
2022 American Transplant Congress
Prospective Evaluation of Donor-Derived Cell-Free DNA (dd-cfDNA) in Monitoring Response to Anti-Rejection Treatment in Kidney Transplant Recipients with Indication Biopsy
L. Benning¹, A. Fink², F. Kälble¹, C. Speer¹, C. Nusshag¹, M. Zeier¹, C. Süsal³, C. Morath¹, T. Tran²
¹Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany, ²Transplantation Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany, ³Transplant Immunology Research Center of Excellence, Koç University Hospital, Istanbul, Turkey
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a marker of allograft injury in kidney transplant recipients (KTR). Little is known about the possible use of dd-cfDNA…