2022 American Transplant Congress
Poor Outcomes in Patients with Transplant Glomerulopathy Independent of Banff Categorization or Therapeutic Interventions
*Purpose: Banff classification is an accepted diagnostic tool, but also used as a tool to define endpoints in clinical trials. There is a need to…2022 American Transplant Congress
A Comparison of Vibration Controlled Transient Elastography, FAST, AGILE-3 and AGILE-4 Scores in Liver Transplant Recipients
*Purpose: Hepatic fibrosis is a strong predictor of clinical outcomes following liver transplantation (LT), however, non-invasive fibrosis assessment remains challenging. Vibration controlled transient elastography has…2022 American Transplant Congress
Novel Biopsy-Based Clinical Phenotype Clustering to Predict Kidney Transplant Outcomes
*Purpose: The purpose of this study was to define novel clinical phenotypes based on biopsy results to enhance biomarker discovery.*Methods: Retrospective analysis of kidney biopsy…2022 American Transplant Congress
Antibody-Mediated Kidney Allograft Rejection (ABMR) Monitoring and Intervention Based on ABMR Subtypes – A Step Towards Precision Diagnosis and Management
*Purpose: The monitoring of kidney allograft for early detection of antibody mediated rejection (ABMR) and subsequent intervention using traditional clinical parameters has been insufficient due…2022 American Transplant Congress
De Novo Anti-Brush Border Antibody Disease in a Kidney Transplant Recipient
Ohio State University, Columbus, OH
*Purpose: Anti-brush border antibody (ABBA) disease is very rare, characterized by tubulointerstitial damage caused by autoantibodies against LDL receptor-related protein 2 (LRP2) in the proximal…2022 American Transplant Congress
Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration
*Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…2022 American Transplant Congress
Concordance of Kidney and Pancreas Rejection on Protocol and for Cause Biopsy in Simultaneous Kidney Pancreas Transplantation
*Purpose: Our aim was to study the concordance rate of kidney and pancreas rejection in patients who received simultaneous kidney-pancreas transplantation (SKP) and its effects…2022 American Transplant Congress
Discrepancy Rates Between Histology (HIST) and Molecular Diagnosis (MDX) of T-cell Mediated Rejection (TCMR) Depend on Choice of Bioinformatics Pipeline
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: HIST based treatment of TCMR has played a key role in the reduction of its incidence to historic lows of ~10%. MDX methods developed…2022 American Transplant Congress
Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression
*Purpose: Rejection therapy has remained unchanged for 60 years and is associated with significant failure and infection rates. Development of new anti-rejection therapies requires mechanistic…2022 American Transplant Congress
Modern Medicine Needs Modern Technology Tools
Ochsner Foundation Hospital, New Orleans, LA
*Purpose: Dd-cfDNA has been used as a non-invasive biomarker for allograft injury and has been shown to detect subclinical rejection with higher predictive power compare…
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