Articles tagged "Biopsy"

2020 American Transplant Congress
Clinical Relevance of Immunoglobulin M Deposition in Peritubular Capillaries in ABO-Incompatible Kidney Transplantation
D. Toki¹, M. Okumi², K. Unagami², Y. Kakuta², H. Ishida², K. Yamashita¹, H. Tachibana¹, A. Hayashida¹, T. Horiuchi¹, Y. Ishiyama¹, K. Honda³, T. Kondo¹, K. Tanabe²
¹Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan, ²Urology, Tokyo Women's Medical University, Tokyo, Japan, ³Anatomy, Showa University, Tokyo, Japan
*Purpose: Immunoglobulin M (IgM) deposition in peritubular capillaries (PTCs) is rarely identified in renal allograft biopsies of ABO-compatible kidney transplantation. In ABO-incompatible kidney transplantation (ABOI-KTx)…
2020 American Transplant Congress
Long Term Outcomes of Kidney Transplantation in Patients with AL-Amyloidosis – The Mayo Clinic Experience
A. Bentall¹, C. Heybali², J. Wen³, A. Hatem¹, C. A. Schinstock¹, E. Lorenz¹, M. El Ters¹, M. Mai⁴, H. Khamash⁵, D. Murray⁶, M. D. Stegall⁷, F. G. Cosio¹, M. P. Alexander⁶, N. Leung¹
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ²School of Medicine, Dokuz Eylul University, Izmir, Turkey, ³National Clinical Research Center of Kidney Disease, Jinling Hospital, Nanjing, China, ⁴Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, ⁵Division of Nephrology and Hypertension, Mayo Clinic, Scottsdale, AZ, ⁶Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, ⁷Department of Transplant Surgery, Mayo Clinic, Rochester, MN
*Purpose: New clone-directed therapies and better definition of hematological response criteria allows assessment of post-kidney transplantation outcomes in patients with light-chain (AL) amyloidosis*Methods: Patients with…
2020 American Transplant Congress
Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation
A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall
Mayo Clinic, Rochester, Rochester, MN
*Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
2020 American Transplant Congress
Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) Are Beneficial to Clarifying ABMR Activity in Ambivalent Cases
H. Zhang¹, C. C. Nast², N. Ammerman³, A. A. Vo³, I. Gallegos³, M. Arevalo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: “Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Here, we…
2020 American Transplant Congress
Urinary Exosomal Hemopexin, a Validated Diagnostic Marker for Rejection in Kidney Transplant Recipients
J. Lee¹, J. Kim², G. Lee², S. Jeon², H. Noh², J. Lim², H. Jung², J. Choi², J. Cho², S. Park², Y. Kim², C. Kim²
¹Internal Medicine, Daegu Fatima Hospital, Daegu, Korea, Republic of, ²Internal Medicine, Kyungpook National University, Daegu, Korea, Republic of
*Purpose: Urinary exosomal hemopexin was identified as a potential diagnostic candidate for kidney allograft rejection in our previous proteomic study. We validated hemopexin as a…
2020 American Transplant Congress
Under-Diagnosed Hyperoxalosis in Transplant-Listed Patients
A. Tariq, L. Lakhani, W. Greenspan, S. Alasfar, F. Naqvi, D. Brennan
Nephrology, Johns Hopkins University, Baltimore, MD
*Purpose: In an era of increasing kidney transplantation (KTx), hyperoxalosis remains an under-recognized cause for allograft failure. Bariatric interventions are significant risk factors for oxalosis,…
2020 American Transplant Congress
Utility of dd-cfDNA in TCMR 1A and Borderline Allograft Rejection
E. Stites¹, D. Kumar², O. Olaitan³, G. Gupta²
¹University of Colorado, Aurora, CA, ²Virginia Commonwealth University, Richmond, VA, ³Rush University, Chicago, CA
*Purpose: The value of donor-derived cell-free DNA (dd-cfDNA, AlloSure) as a molecular marker for the early diagnosis of mild T-cell mediated rejection (Banff TCMR 1A…
2020 American Transplant Congress
High-Activity Classical and Alternative Complement Pathway Genotypes – Association with Donor-Specific Antibody-Triggered Injury and Renal Allograft Survival
R. Reindl-Schwaighofer¹, B. Mezö², F. Eskandary¹, A. Heinzel¹, M. Wahrmann¹, K. Doberer¹, A. Heilos³, G. Bond¹, J. Kläger⁴, N. Kozakowski⁴, H. Haslacher⁵, R. Oberbauer¹, O. Viklický⁶, P. Hruba⁶, P. F. Halloran⁷, K. Rusai³, Z. Prohászka⁸, G. A. Böhmig¹
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary, ³Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, ⁶Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁷Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada, ⁸Department of Medicine III, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
*Purpose: Complement may contribute to donor-specific antibody (DSA)-triggered transplant injury. Here, we investigated whether the intrinsic strength of classical (CP) and alternative complement pathways (AP)…
2020 American Transplant Congress
Donor-Derived Cell-Free DNA Combined with Histology Improves Prediction of eGFR Decline in Kidney Transplant Recipients over Histology Alone
M. Gillespie, M. Haas, K. Lim, A. Vo, A. Peng, R. Najjar, S. Sethi, S. Jordan, E. Huang
Cedars-Sinai, Los Angeles, CA
*Purpose: Higher Banff inflammation and chronicity scores on kidney transplant (KTx) biopsies (Bx) have been associated with poorer graft survival, but Bx scores alone imperfectly…
2020 American Transplant Congress
From Marginal to Meaningful: Donor Liver Biopsy Increases Donation Rates amongst Elderly Donors
J. A. Steggerda¹, M. B. Bloom¹, K. Mahendraraj¹, G. Voidonikolas¹, T. Todo¹, M. Noureddin², N. N. Nissen¹, A. S. Klein¹, I. K. Kim¹
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA, ²Hepatology, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA
*Purpose: Recently, there has been public scrutiny on the non-utilization of elderly donors in liver transplantation. Here, we evaluate the influence of donor liver biopsy…