Articles tagged "Biopsy"

2021 American Transplant Congress
Is Subclinical Allograft Rejection by 2019 Banff Criteria Associated with Worse Kidney Allograft Outcomes? Comparison Between 2007 and 2019 Banff Criteria
M. T. Victor¹, S. Park², K. Guo¹, L. Zhao¹, J. Friedewald³
¹Feinberg School of Medicine, Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern Univeristy, Chicago, IL, ³Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: We hypothesize that Subclinical Acute Rejection (SubAR) under the new Banff 2019 criteria will be more strongly associated with a 2-year composite endpoint (2Y-CCE)…
2020 American Transplant Congress
Use of tCRM to Aid Diagnosis of Allograft Rejection in Kidney Transplantation
A. Zarinsefat¹, J. Liberto¹, I. Damm¹, C. Ramirez², J. Guerra², J. Alberu², M. Sarwal¹
¹University of California San Francisco, San Francisco, CA, ²Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico
*Purpose: To apply an unbiased, quantitative, molecular profiling score for graft inflammation using standardized assays, in the context of a prospective clinical trial in kidney…
2020 American Transplant Congress
Impact of Chronic Changes on Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation (DDKTx)
J. Ninan, R. Heilman, M. Smith, J. Harbell, S. S. Nair, C. Jadloweic, H. Khamash, A. Moss, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: The value of PBx is unclear. The aim of this study was to determine the prognostic value of chronic changes on PBx on graft…
2020 American Transplant Congress
Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies
I. Moinuddin¹, D. Kumar¹, L. Kamal¹, A. King¹, L. Kang¹, M. Levy¹, S. Bobba¹, D. Massey¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
2020 American Transplant Congress
Glomerulitis in One-Hour Biopsy after ABO-Blood Type Incompatible Kidney Transplantation Sensitively Suggests Occurrence of Antibody-Mediated Rejection
D. Iwami, K. Hotta, N. Iwahara, N. Shinohara
Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
*Purpose: Antibody-mediated rejection (ABMR) after ABO-blood type-incompatible kidney transplantation (ABOi-KTx) can affect transplant outcome even lead to allograft loss unless promptly diagnosed and adequately treated.…
2020 American Transplant Congress
Yield and Utility of Surveillance Kidney Biopsies in Pediatric Kidney Transplant Recipients at Various Time Points Post-Transplant
A. Landsberg¹, M. Riazy², T. Blydt-Hansen¹
¹Nephrology, BC Children's Hospital, Vancouver, BC, Canada, ²Pathology and Laboratory Medicine, St. Paul's Hospital, Vancouver, BC, Canada
*Purpose: There lacks consensus regarding the appropriate timing of routine surveillance biopsies (SB) for pediatric kidney transplant recipients. We evaluated the yield of positive biopsy…
2020 American Transplant Congress
Avoiding Surveillance Biopsy: How? When? Now!
A. Ang¹, C. Schieve², S. Rose², C. Kew¹, M. R. First², R. B. Mannon¹
¹School of Medicine, University of Alabama, Birmingham, Birmingham, AL, ²Transplant Genomics Inc., Mansfield, MA
*Purpose: The TruGraf™ blood test measures a specific gene expression signature in the peripheral blood mononuclear cells to enable noninvasive serial assessment of kidney transplant…
2020 American Transplant Congress
Machine Learning to Predict Deceased Donor Liver Biopsy Results
C. Martinez, A. Placona
United Network for Organ Sharing, Richmond, VA
*Purpose: Biopsies are often cited as a key factor on whether to accept a deceased liver offer. Motivated by the influential role of biopsy findings…
2020 American Transplant Congress
Validation of Prognostic Index for Allograft Outcome in Kidney Transplant Recipients with Transplant Glomerulopathy
M. Talwar¹, V. Balaraman¹, A. Bhalla¹, O. Cseprekal², M. Yazawa¹, P. S. Podila³, A. Azhar¹, L. N. Cossey⁴, J. D. Eason¹, M. Z. Molnar¹
¹James D. Eason Transplant Institute, Methodist University Hospital, Memphis, TN, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ³Faith & Health Division, Methodist Le Bonheur Healthcare, Memphis, TN, ⁴Arkanalabs, Little Rock, AR
*Purpose: Kidney transplant recipients with Transplant Glomerulopathy (TG) have very poor allograft survival compared to those without TG. The objective of this research was to…
2020 American Transplant Congress
Sex-Dependent Resistance to Ischemia-Reperfusion Injury in Mouse and Human Liver Transplantation
S. Kageyama, H. Kojima, K. Kadono, H. Hirao, K. J. Dery, S. Younan, T. Ito, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for early allograft dysfunction and rejection in orthotopic liver transplantation (OLT). The influence of sex on…