ATC Abstracts

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Articles tagged "Biopsy"

  • 2022 American Transplant Congress

    Concordance of Kidney and Pancreas Rejection on Protocol and for Cause Biopsy in Simultaneous Kidney Pancreas Transplantation

    P. Budhiraja, R. Heilman, H. Khamash, A. Jaramillo, D. Ramon, H. Me, J. Ninan, S. Reddy, s. S. Misra, H. Chakkera

    Mayo Clinic, Phoenix, AZ

    *Purpose: Our aim was to study the concordance rate of kidney and pancreas rejection in patients who received simultaneous kidney-pancreas transplantation (SKP) and its effects…
  • 2022 American Transplant Congress

    Discrepancy Rates Between Histology (HIST) and Molecular Diagnosis (MDX) of T-cell Mediated Rejection (TCMR) Depend on Choice of Bioinformatics Pipeline

    M. Ellison, D. Spagnolo, P. Randhawa

    University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: HIST based treatment of TCMR has played a key role in the reduction of its incidence to historic lows of ~10%. MDX methods developed…
  • 2022 American Transplant Congress

    Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression

    T. Shi1, A. Burg1, K. Roskin2, J. Rush3, B. Haraldsson3, A. Shields4, R. Alloway4, E. Woodle5, D. Hildeman1

    1Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Novartis Pharmaceuticals AG, Basel, Switzerland, 4Internal Medicine, University of Cincinnati, Cincinnati, OH, 5Surgery, University of Cincinnati, Cincinnati, OH

    *Purpose: Rejection therapy has remained unchanged for 60 years and is associated with significant failure and infection rates. Development of new anti-rejection therapies requires mechanistic…
  • 2022 American Transplant Congress

    Modern Medicine Needs Modern Technology Tools

    Z. S. Soltani,, S. Soltani

    Ochsner Foundation Hospital, New Orleans, LA

    *Purpose: Dd-cfDNA has been used as a non-invasive biomarker for allograft injury and has been shown to detect subclinical rejection with higher predictive power compare…
  • 2022 American Transplant Congress

    Proteinuria in Diseased Kidney Transplant Donors for Prediction of Chronic Lesions in Pre-Transplant Biopsies – A Prospective Observational Study

    F. Haupenthal1, J. Kläger2, F. Bauernfeind3, A. Heinzel1, K. Doberer1, K. Mayer1, L. Naar1, M. Eigenschink1, K. Hu1, H. Regele2, T. Szekeres4, R. Reindl-Schwaighofer1, G. Bond1

    1Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria, 2Department of Pathology, Medical University of Vienna, Vienna, Austria, 3Department of Learning, Informatics, Management and Ethics, Karolinska Institute, Stockholm, Sweden, 4Division of Clinical Chemistry, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

    *Purpose: Pre-transplant kidney graft biopsies have been suggested for organ quality assessment. Data on the association between donor proteinuria and organ quality of deceased donors…
  • 2022 American Transplant Congress

    TCMR in Late Kidney Transplant Biopsies Shows Less Molecular TCMR Activity and More Fibrosis Despite Persistence of Tubulitis and Interstitial Infiltrate

    K. S. Madill-Thomsen1, J. Reeve1, P. Halloran1, .. and the INTERCOMEX Study Group2

    1Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, 2., ., AB, Canada

    *Purpose: We studied the relationship between time post-transplant and molecular T cell-mediated rejection (TCMR) activity in a population of indication kidney transplant biopsies.*Methods: Updated rejection-based…
  • 2022 American Transplant Congress

    Evaluation of Genotype Based Clustering Method of Single-Cell RNA-Sequencing Data from Human Kidney Allograft Biopsies

    G. Thareja1, A. Belkadi1, S. Rahim2, H. Yang2, F. B. Mueller2, K. Suhre1, M. Suthanthiran2, T. Muthukumar2

    1Weill Cornell Medicine, Doha, Qatar, 2Weill Cornell Medicine, New York, NY

    *Purpose: Single-cell RNA sequencing (scRNA-seq) characterizes expression profiles of individual cells, providing novel insights into new cell types or new cell states that were not…
  • 2022 American Transplant Congress

    A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients

    S. Parajuli, F. Aziz, N. Garg, S. E. Panzer, K. Van Hyfte, K. Degner, S. Reese, L. Ptak, N. Wilson, A. Djamali

    University of Wisconsin, Madison, WI

    *Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…
  • 2022 American Transplant Congress

    The Correlation Between Kidney Donor Risk Index, Kidney Graft Function and Histological Changes in Early Post-Transplant Renal Biopsy

    N. Slabiak-Blaz, A. Kujawa-Szewieczek, A. Kolonko, H. Karkoszka, A. Wiecek, G. Piecha

    Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland

    *Purpose: An appropriate assessment of donor organ quality is crucial to optimize the kidney allocation and improve the long-term outcomes. Kidney Donor Risk Index (KDRI),…
  • 2022 American Transplant Congress

    Molecular Associations in Kidney Transplant Biopsies in the Trifecta Study Indicate That at Least Three Distinct Processes Release Dd-cfDNA: ABMR, TCMR, and Injury

    P. F. Halloran1, J. Reeve1, K. S. Madill-Thomsen1, Z. Demko2, A. Prewett2, P. Billings2, .. and the Trifecta Investigators3

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Natera Inc., San Carlos, CA, 3., ., AB, Canada

    *Purpose: In the Trifecta study (ClinicalTrials.gov # NCT04239703 53), elevated plasma dd-cfDNA is associated with molecular rejection in kidney transplant indication biopsies, particularly active ABMR…
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