2019 American Transplant Congress
Evaluating Liver Regeneration during Normothermic Machine Perfusion in Hepatectomized Rat Liver Model
*Purpose: Realizing the liver’s unique ability to regenerate, this ongoing study examines Normothermic Machine Perfusion (NMP) as a promising platform for evaluating & potentially simulating…2019 American Transplant Congress
Kidney Regeneration with Biomimetic Vascular Scaffolds Based on Vascular Corrosion Casts
*Purpose: We have developed a biomimetic renal vascular scaffold based on a vascular corrosion casting technique. In this study, we evaluated the feasibility of using…2019 American Transplant Congress
Tolerogenic Nanoparticles Targeting the Aryl Hydrocarbon Receptor
*Purpose: The aryl hydrocarbon receptor (AHR) has been shown to have a central role in the ability of dendritic cells (DCs) to direct differentiation of…2019 American Transplant Congress
Preservation of Pancreatic Islets with Stem Cell Derived CD34+ Vascular Endothelial Progenitor Cells
1Surgery, UCSF, San Francisco, CA, 2Diabetes Center, UCSF, San Francisco, CA
*Purpose: Islet transplantation can cure Type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets when removed from their native…2019 American Transplant Congress
Engineering Regulatory T Cells With TCR-Signaling-Responsive Interleukin 2 Nanoparticles Provides In Situ Suppression Of Alloimmunity
*Purpose: Adoptive cell transfer of regulatory T cells (TReg) has shown great potential in animal models of auto- and alloimmunity. The translation of TReg therapies…2019 American Transplant Congress
Pancreatic Extracellular Matrix Improves Human Islet Culture and Function In Vitro
Virginia Commonwealth University, Richmond, VA
*Purpose: Islet transplantation is a thriving therapy for patients with Chronic Pancreatitis and Type-1 Diabetes. Within the pancreas, the islets are surrounded by Extracellular Matrix…2019 American Transplant Congress
The Efficacy of Spheroidal Hepatocytes for Hepatocyte Transplantation
Department of Gastroenterological Surgery Ⅰ Hokkaido University Graduate School, Sapporo, Japan
*Purpose: Hepatocyte transplantation (HCTx) is expected to expand its application as a next generation therapy alternative to liver transplantation. Following HCTx, the liver function improves…2018 American Transplant Congress
Sensing T Cell Killing Activity with Granzyme B Activity Probes
Purpose: We developed activity-based probes that sense Granzyme B (GzmB) activity during alloreactive T cell killing of donor cellsMethods: FITC-labelled GzmB substrate (IEFDSG) was synthesized…2018 American Transplant Congress
Biomaterial-Based Localized and Controlled Delivery of Tofacitinib to Actuate Enhanced Costimulation Blockade and Promote Long-Term Transplant Survival
Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are highly needed. We investigated two innovative drug…2018 American Transplant Congress
Pancreas Decellularization Protocol – Comparison of Methods
Foundation of Research and Science Development, Otwock, Poland.
Background: Whole organ decellularization is gaining a lot of popularity since its development in tissue engineering. It is a process which allows to create complex…
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