2019 American Transplant Congress
Towards 3D-Bioprinting of Bionic Pancreas: Effect of Pressure on the Viability of Pancreatic Islets
Foundation for Research and Science Development, Warsaw, Poland
*Purpose: 3D bioprinting is the wave of the future in terms of constructing functional, human organs. 3D bioprinting of a bioactive tissue scaffold and Langerhans…2019 American Transplant Congress
Scaffold-Free 3D-Bioprinting of Human Extrahepatic Bile Duct
*Purpose: Biliary complications are common especially in living and also in deceased donor liver transplantation (LT). Presence of multiple orifices in biliary anastomosis and ischemia,…2019 American Transplant Congress
Balance between Low DNA Concentration and Structural Damage of Extracellular Matrix during Recellularization Procedure as a Key to Successful Recellularization
Foundation of Research and Science Development, Warsaw, Poland
*Purpose: Recellularization is considered to be a potential way to solve the problem of organ shortage for transplantation. One of the conditions for the use…2019 American Transplant Congress
Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants
Rabin Medical Center, Petah-Tiqwa, Israel
*Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…2019 American Transplant Congress
Ex Vivo Assessment of Marginal Human Kidneys Using Computed Tomography
*Purpose: Thousands of ‘marginal’ organs are discarded each year despite a severe organ shortage. This has motivated development of new technologies, such as ex vivo…2019 American Transplant Congress
MHC Molecule-Ablated Human Endothelial Cells Form Alloimmune-Evasive Microvessels
*Purpose: “Off the shelf” tissue-engineered organs will require use of allogeneic cell sources. Allogeneic human endothelial cells (ECs), necessary for organ perfusion, can initiate graft…2019 American Transplant Congress
Organ Transportation by Drone: Surgeon Perspectives
1University of Maryland, Baltimore, MD, 2Surgery, University of Maryland, Baltimore, MD
*Purpose: We recently reported on the first transport of a human kidney using a drone. Ahead of large scale adoption of such a technology, understanding…2018 American Transplant Congress
Activity Nanosensors for Early and Noninvasive Detection of Acute Organ Transplant Rejection
Purpose: We engineered activity nanosensors that sense anti-allograft T cell activity in vivo to noninvasively detect the onset of acute cellular rejection from urine.Methods: Granzyme…2018 American Transplant Congress
Engineering Regulatory T Cells with Interleukin (IL-)2 Nanogel for Improved Alloimmune Suppression
Clinical trials of adoptively transferred regulatory T cells (TRegs) have been hindered by the short lifespan of these transferred TRegs. Systemic injection of low-dose interleukin…2018 American Transplant Congress
Sensing T Cell Killing Activity with Granzyme B Activity Probes
Purpose: We developed activity-based probes that sense Granzyme B (GzmB) activity during alloreactive T cell killing of donor cellsMethods: FITC-labelled GzmB substrate (IEFDSG) was synthesized…
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