ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bioengineering"

  • 2019 American Transplant Congress

    Engineering Regulatory T Cells With TCR-Signaling-Responsive Interleukin 2 Nanoparticles Provides In Situ Suppression Of Alloimmunity

    S. K. Eskandari1, M. B. Melo2, I. Sulkaj1, N. Li2, S. Cai1, H. Allos1, J. Y. Choi1, D. J. Irvine2, J. R. Azzi1

    1Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 2David H. Koch Institute for Integrative Cancer Research, Cambridge, MA

    *Purpose: Adoptive cell transfer of regulatory T cells (TReg) has shown great potential in animal models of auto- and alloimmunity. The translation of TReg therapies…
  • 2019 American Transplant Congress

    Pancreatic Extracellular Matrix Improves Human Islet Culture and Function In Vitro

    Y. Shindo, R. Pouillot, B. M. Young, P. Link, R. L. Heise, M. F. Levy, M. A. Kanak

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Islet transplantation is a thriving therapy for patients with Chronic Pancreatitis and Type-1 Diabetes. Within the pancreas, the islets are surrounded by Extracellular Matrix…
  • 2019 American Transplant Congress

    The Efficacy of Spheroidal Hepatocytes for Hepatocyte Transplantation

    K. Shibuya, M. Watanabe, Y. Ganchiku, R. Kanazawa, Y. Koshizuka, M. Zaitsu, R. Goto, A. Taketomi

    Department of Gastroenterological Surgery Ⅰ Hokkaido University Graduate School, Sapporo, Japan

    *Purpose: Hepatocyte transplantation (HCTx) is expected to expand its application as a next generation therapy alternative to liver transplantation. Following HCTx, the liver function improves…
  • 2019 American Transplant Congress

    Utilizing Imagestream Technology to Determine Hepatocellular CD38 Localization

    Y. Lee, J. Kim, B. F. Reader, C. Akateh, K. R. Maynard, K. W. Washburn, J. L. Zweier, B. A. Whitson, S. M. Black

    Department of Cardiac Surgery, The Ohio State Univ. Medical Center, Columbus, OH

    *Purpose: CD38 is an ecto-enzyme that modulates intracellular calcium levels by producing potent secondary messengers, which utilize the cellular NAD pool and lead to increased…
  • 2019 American Transplant Congress

    Regeneration of Kidney with a Novel Biomimetic Vascular Scaffold

    S. Min1, H. Mo1, A. Han1, J. Ha1, J. Yoo2

    1Seoul National University Hospital, Seoul 110-744, Korea, Republic of, 2Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

    *Purpose: Appropriate vascularization is one of the most important issues to be addressed in the clinical application of 3D bioengineered organ.*Methods: We have fabricated biomimetic…
  • 2019 American Transplant Congress

    Modeling Patients as Dynamical Systems: Evaluating the Efficiency of Kidney Transplantation through Multi-Stage Data Envelopment Analysis

    F. J. Santos Arteaga1, D. Di Caprio2, D. Cucchiari3, J. M. Campistol3, F. Oppenheimer3, F. Diekmann3, I. Revuelta3

    1Faculty of Economics and Management, Free University of Bolzano, Bolzano, Italy, 2Department of Mathematics and Statistics, York University, Toronto, ON, Canada, 3Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain

    *Purpose: The occurrence of kidney graft loss is determined by a large set of variables interacting across the different stages of the transplantation process. This…
  • 2019 American Transplant Congress

    Towards 3D-Bioprinting of Bionic Pancreas: Effect of Pressure on the Viability of Pancreatic Islets

    M. Klak, K. Kosowska, E. Majdanska, T. Dobrzanski, A. Berman, L. Kaczynski, P. Kowalska, M. Gomolka, M. Wszola

    Foundation for Research and Science Development, Warsaw, Poland

    *Purpose: 3D bioprinting is the wave of the future in terms of constructing functional, human organs. 3D bioprinting of a bioactive tissue scaffold and Langerhans…
  • 2019 American Transplant Congress

    Scaffold-Free 3D-Bioprinting of Human Extrahepatic Bile Duct

    K. Saglam1, W. Zhang1, L. J. Smith2, A. Isidan1, A. M. Chen1, R. A. Naqvi1, E. Gramelspacher1, P. Li1, B. Ekser1

    1Transplant Division, Department of Surgery, Indiana University, Indianapolis, IN, 23D-Bioprinting Core, Indiana University School of Medicine, Indianapolis, IN

    *Purpose: Biliary complications are common especially in living and also in deceased donor liver transplantation (LT). Presence of multiple orifices in biliary anastomosis and ischemia,…
  • 2019 American Transplant Congress

    Balance between Low DNA Concentration and Structural Damage of Extracellular Matrix during Recellularization Procedure as a Key to Successful Recellularization

    A. Berman, A. Adamiok, G. Tynicki, L. Kaczynski, M. Gomolka, M. Klak, M. Wszola

    Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: Recellularization is considered to be a potential way to solve the problem of organ shortage for transplantation. One of the conditions for the use…
  • 2019 American Transplant Congress

    Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants

    S. Cohen, S. Partouche, M. Gurevich, V. Mezhybovsky, V. Tennak, S. Eisner, E. Nesher, E. Mor

    Rabin Medical Center, Petah-Tiqwa, Israel

    *Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…
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