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Articles tagged "Bioengineering"

  • 2019 American Transplant Congress

    Regeneration of Kidney with a Novel Biomimetic Vascular Scaffold

    S. Min1, H. Mo1, A. Han1, J. Ha1, J. Yoo2

    1Seoul National University Hospital, Seoul 110-744, Korea, Republic of, 2Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

    *Purpose: Appropriate vascularization is one of the most important issues to be addressed in the clinical application of 3D bioengineered organ.*Methods: We have fabricated biomimetic…
  • 2019 American Transplant Congress

    Modeling Patients as Dynamical Systems: Evaluating the Efficiency of Kidney Transplantation through Multi-Stage Data Envelopment Analysis

    F. J. Santos Arteaga1, D. Di Caprio2, D. Cucchiari3, J. M. Campistol3, F. Oppenheimer3, F. Diekmann3, I. Revuelta3

    1Faculty of Economics and Management, Free University of Bolzano, Bolzano, Italy, 2Department of Mathematics and Statistics, York University, Toronto, ON, Canada, 3Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain

    *Purpose: The occurrence of kidney graft loss is determined by a large set of variables interacting across the different stages of the transplantation process. This…
  • 2019 American Transplant Congress

    Towards 3D-Bioprinting of Bionic Pancreas: Effect of Pressure on the Viability of Pancreatic Islets

    M. Klak, K. Kosowska, E. Majdanska, T. Dobrzanski, A. Berman, L. Kaczynski, P. Kowalska, M. Gomolka, M. Wszola

    Foundation for Research and Science Development, Warsaw, Poland

    *Purpose: 3D bioprinting is the wave of the future in terms of constructing functional, human organs. 3D bioprinting of a bioactive tissue scaffold and Langerhans…
  • 2019 American Transplant Congress

    Scaffold-Free 3D-Bioprinting of Human Extrahepatic Bile Duct

    K. Saglam1, W. Zhang1, L. J. Smith2, A. Isidan1, A. M. Chen1, R. A. Naqvi1, E. Gramelspacher1, P. Li1, B. Ekser1

    1Transplant Division, Department of Surgery, Indiana University, Indianapolis, IN, 23D-Bioprinting Core, Indiana University School of Medicine, Indianapolis, IN

    *Purpose: Biliary complications are common especially in living and also in deceased donor liver transplantation (LT). Presence of multiple orifices in biliary anastomosis and ischemia,…
  • 2019 American Transplant Congress

    Balance between Low DNA Concentration and Structural Damage of Extracellular Matrix during Recellularization Procedure as a Key to Successful Recellularization

    A. Berman, A. Adamiok, G. Tynicki, L. Kaczynski, M. Gomolka, M. Klak, M. Wszola

    Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: Recellularization is considered to be a potential way to solve the problem of organ shortage for transplantation. One of the conditions for the use…
  • 2019 American Transplant Congress

    Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants

    S. Cohen, S. Partouche, M. Gurevich, V. Mezhybovsky, V. Tennak, S. Eisner, E. Nesher, E. Mor

    Rabin Medical Center, Petah-Tiqwa, Israel

    *Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…
  • 2019 American Transplant Congress

    Ex Vivo Assessment of Marginal Human Kidneys Using Computed Tomography

    M. K. Harris1, J. R. DiRito2, H. Liu3, N. Boutagy3, C. Liu4, S. Hosgood2, D. Mulligan1, M. L. Nicholson2, A. Sinusas3, D. Haakinson1, G. T. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Surgery, University of Cambridge, Cambridge, United Kingdom, 3Yale Translational Research Imaging Center, New Haven, CT, 4Radiology, Yale School of Medicine, New Haven, CT

    *Purpose: Thousands of ‘marginal’ organs are discarded each year despite a severe organ shortage. This has motivated development of new technologies, such as ex vivo…
  • 2019 American Transplant Congress

    MHC Molecule-Ablated Human Endothelial Cells Form Alloimmune-Evasive Microvessels

    J. Merola1, M. Reschke2, L. Qin1, S. Spindler1, R. W. Pierce3, T. D. Manes4, G. Li1, L. Bracaglia2, N. Kirkiles-Smith4, T. Baltazar4, W. Saltzman2, G. T. Tietjen1, G. Tellides1, J. S. Pober4

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, 3Pediatrics, Yale School of Medicine, New Haven, CT, 4Immunobiology, Yale School of Medicine, New Haven, CT

    *Purpose: “Off the shelf” tissue-engineered organs will require use of allogeneic cell sources. Allogeneic human endothelial cells (ECs), necessary for organ perfusion, can initiate graft…
  • 2019 American Transplant Congress

    Organ Transportation by Drone: Surgeon Perspectives

    T. Talaie1, R. Barth2, J. R. Scalea1

    1University of Maryland, Baltimore, MD, 2Surgery, University of Maryland, Baltimore, MD

    *Purpose: We recently reported on the first transport of a human kidney using a drone. Ahead of large scale adoption of such a technology, understanding…
  • 2019 American Transplant Congress

    Hepatic Stellate Cells and Liver Derived Endothelial Cells Improve Scaffold-Free 3D-Bioprintied Liver Model

    A. M. Chen1, W. Zhang1, C. J. Koehler1, K. Saglam1, A. Isidan1, J. R. Walsh1, R. A. Naqvi1, E. Gramelspacher1, L. J. Smith2, P. Li1, B. Ekser1

    1Transplant Division, Department of Surgery, Indiana University, Indianapolis, IN, 23D-Bioprinting Core, Indiana University School of Medicine, Indianapolis, IN

    *Purpose: Hepatic stellate cells (HSC) comprise about 2-8% of liver cells and are vital to hepatocellular function. Scaffold-free 3D-bioprinting (SF3DBP) allows creation of realistic tissue…
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