ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2016 American Transplant Congress

    VDJ Immune Repertoire Sequencing Predicts Patients at Risk of Alloimmune Injury.

    M. Sirota,1 T. Sigdel,1 S. Boyd,2 A. Fire,2 M. Sarwal.1

    1Surgery and Bioinformatics, UCSF, San Francisco, CA; 2Genetics, Stanford University, Palo Alto, CA.

    Background: The complex repertoire of immune receptors generated by B cells enables allo-recognition in the context of transplantation across HLA barriers, and is a major…
  • 2016 American Transplant Congress

    Patients Treated with Belatacept Show Low Levels of APRIL and HLA Antibodies.

    M. Rial,1 N. Ambrosi,2 F. Caro,2 D. Curcio,1 J. Salaberry,2 O. Guardia,1 A. Dotta,1 D. Guerrieri,2 K. Padros,3 E. Chuluyan,2 D. Casadei.

    1Instituto de Nefrología, Nephrology, Buenos Aires, Argentina; 2CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; 3PRICAI, Fundación Favaloro, Buenos Aires, Argentina.

    Belatacept, a fusión protein that blocks the B7-CD28 costimulation pathway, decreases the level of antibodies in non-human primates and murine models but, few studies have…
  • 2016 American Transplant Congress

    Selective Deletion of Notch2 on B Cells Abrogates Alloantibody Production in Fully MHC-Mismatched Cardiac and Skin Transplant Models.

    N. Murakami, C. Magee, T. Borges, J. Azzi, L. Riella.

    Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA.

    Alloantibody-mediated injury remains a major challenge for the improvement of long-term graft survival and there is no effective therapy to prevent alloantibody generation post-transplant. The…
  • 2016 American Transplant Congress

    Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.

    A. Cherukuri, R. Mehta, S. Ogunde, S. Hariharan, D. Rothstein.

    UPMC, Pittsburgh.

    In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…
  • 2016 American Transplant Congress

    Breadth of HLA-Specific B Cell Reactivity and Frequency Assessed by a Novel Multiplex Bead Based Assay Predicts and Correlates with Rejection in Kidney Transplant Recipients.

    A. Akl, Z. Ilyas, O. Traitanon, L. Gallon, A. Tambur, M. Ansari.

    Northwestern University, Chicago.

    Introduction: Recipients with broad sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) are at higher immunologic risk for poor graft…
  • 2016 American Transplant Congress

    Prolongation of Graft Survival by Anti-TIM1 Is Specifically Mediated by IL-10+ Bregs and Is Not Dependent on IL-35 or Plasma Cell Differentiation.

    Y. Zhou,1,2 Q. Ding,1 A. Cherukuri,1 D. Rothstein.1

    1Thomas E. Starzl Transplantation Institute, Departments of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2School of Medicine, Tsinghua University, Beijing, China.

    In B cell-deficient mice, prolonged islet allograft survival (GS) mediated by anti-TIM1 depends on transfer of IL-10 competent B cells. However, such regulatory B cells…
  • 2016 American Transplant Congress

    PD-L1/PD-L2-Expressing B-1a Cells Inhibit Allo-Reactive T Cells in Mice.

    T. Hirose,1,2 Y. Tanaka,1 H. Ohdan.1

    1Transplant Surgery, Hiroshima University, Hiroshima, Japan; 2Urology, Hokkaido University, Sapporo, Hokkaido, Japan.

    Donor lymphocyte infusion (DLI) induces donor-specific hypo responsiveness or immune-tolerance among allo-reactive T cells in different organ transplantation models. However, the optimal cell source or…
  • 2016 American Transplant Congress

    Re-Examining the Role of B-1 Cells in a Murine Model of Renal Ischemia Reperfusion Injury.

    D. Firl,1,2,3 A. Das,1 J. Fung,2 M. Carroll.1

    1Harvard Medical School, Boston; 2Cleveland Clinic Lerner College of Medicine, Cleveland; 3HHMI, Chevy Chase.

    We propose a reexamination of the currently underappreciated role of B-1 cells in IRI. Ischemia reperfusion injury (IRI) is a two phase insult composed of…
  • 2016 American Transplant Congress

    Fate of Endogenous Alloreactive B Cells in Transplant Tolerance.

    J. Chen,1 J. Yang,1 A. Akl,1 Q. Wang,1 D. Yin,1 R. Sciammas,2 A. Chong.1

    1Transplant Surgery, University of Chicago, Chicago, IL; 2Methodist Research Institute, Methodist Medical Center, Houston, TX.

    The conceptual underpinning of our studies is that robust tolerance requires multiple mechanisms to enforce functional quiescence of alloreactive T and B cells. While much…
  • 2016 American Transplant Congress

    Cross-Talk Between TLR and BCR Pathways Induces CNI-Resistance in B-Cells Responding to Blood Group A-Antigens: A Novel Paradigm for Treatment with TLR-Inhibitor for CNI-Resistant AMR.

    H. Sakai, Y. Tanaka, H. Ohdan.

    Hiroshima University, Hiroshima, Japan.

    [Aim] Bacterial infections after ABO-incompatible transplantation are associated with refractory antibody (Ab)-mediated rejection (AMR). We demonstrated that bacterial pathogens provoke B cells, responding to human…
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