2016 American Transplant Congress
VDJ Immune Repertoire Sequencing Predicts Patients at Risk of Alloimmune Injury.
1Surgery and Bioinformatics, UCSF, San Francisco, CA; 2Genetics, Stanford University, Palo Alto, CA.
Background: The complex repertoire of immune receptors generated by B cells enables allo-recognition in the context of transplantation across HLA barriers, and is a major…2016 American Transplant Congress
Patients Treated with Belatacept Show Low Levels of APRIL and HLA Antibodies.
Belatacept, a fusión protein that blocks the B7-CD28 costimulation pathway, decreases the level of antibodies in non-human primates and murine models but, few studies have…2016 American Transplant Congress
Selective Deletion of Notch2 on B Cells Abrogates Alloantibody Production in Fully MHC-Mismatched Cardiac and Skin Transplant Models.
Alloantibody-mediated injury remains a major challenge for the improvement of long-term graft survival and there is no effective therapy to prevent alloantibody generation post-transplant. The…2016 American Transplant Congress
Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.
In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…2016 American Transplant Congress
Breadth of HLA-Specific B Cell Reactivity and Frequency Assessed by a Novel Multiplex Bead Based Assay Predicts and Correlates with Rejection in Kidney Transplant Recipients.
Northwestern University, Chicago.
Introduction: Recipients with broad sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) are at higher immunologic risk for poor graft…2016 American Transplant Congress
Prolongation of Graft Survival by Anti-TIM1 Is Specifically Mediated by IL-10+ Bregs and Is Not Dependent on IL-35 or Plasma Cell Differentiation.
In B cell-deficient mice, prolonged islet allograft survival (GS) mediated by anti-TIM1 depends on transfer of IL-10 competent B cells. However, such regulatory B cells…2016 American Transplant Congress
PD-L1/PD-L2-Expressing B-1a Cells Inhibit Allo-Reactive T Cells in Mice.
Donor lymphocyte infusion (DLI) induces donor-specific hypo responsiveness or immune-tolerance among allo-reactive T cells in different organ transplantation models. However, the optimal cell source or…2016 American Transplant Congress
Re-Examining the Role of B-1 Cells in a Murine Model of Renal Ischemia Reperfusion Injury.
We propose a reexamination of the currently underappreciated role of B-1 cells in IRI. Ischemia reperfusion injury (IRI) is a two phase insult composed of…2016 American Transplant Congress
Fate of Endogenous Alloreactive B Cells in Transplant Tolerance.
The conceptual underpinning of our studies is that robust tolerance requires multiple mechanisms to enforce functional quiescence of alloreactive T and B cells. While much…2016 American Transplant Congress
Cross-Talk Between TLR and BCR Pathways Induces CNI-Resistance in B-Cells Responding to Blood Group A-Antigens: A Novel Paradigm for Treatment with TLR-Inhibitor for CNI-Resistant AMR.
Hiroshima University, Hiroshima, Japan.
[Aim] Bacterial infections after ABO-incompatible transplantation are associated with refractory antibody (Ab)-mediated rejection (AMR). We demonstrated that bacterial pathogens provoke B cells, responding to human…
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