ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2017 American Transplant Congress

    TIM-4 Identifies Pro-Inflammatory B Effector Cells That Are Potent Drivers of Alloimmunity and Allograft Rejection Through Expression of Both IFN-γ and IL-17.

    Q. Ding, K. Mohib, D. Rothstein.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh

    B cells can either augment or inhibit immune responses due to the presence both regulatory (Bregs) and effector (Beff) B cells expressing anti- or pro-…
  • 2017 American Transplant Congress

    Suppression of T Cell Proliferation by CpG-Activated B Cells Depends on Granzyme-B and Cell-Cell Contact, but Not on IL-10.

    L. Kojima,1 S. Kimura,1,2 K. Lee,1 C. Schuetz,1 L. Washburn,1 K. Deng,1 H. Tector,1 B. Amundsen,1,2 D. Ndishabandi,1,2 A. Markmann,1 M. Markmann-Porch,1 T. Oura,1 A. Alessandrini,1,2 J. Kim,1 H. Yeh,1,2 J. Markmann.1,2

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, MA

    Background: Our previous studies document the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. However, we have been largely unsuccessful in demonstrating…
  • 2017 American Transplant Congress

    Senescence and Uremia Effects in Circulating T Cells Diverge in TREG Population and Cause T Cell Shift to a Memory Profile.

    G. Freitas,1 M. Fernandes,1 F. Agena,1 O. Jabuul,2 V. Coelho,3 F. Lemos,1 F. Ramos,1 A. Triboni,1 E. David-Neto,1 N. Galante.1

    1Renal Transplantation Service, University of Sao Paulo, Sao Paulo, Brazil; 2Department of Geriatrics, University of Sao Paulo, Sao Paulo, Brazil; 3Laboratory of Immunology, InCor, University of Sao Paulo, Sao Paulo, Brazil

    Elderly kidney transplant recipients(EKtx) have higher malignancies and infections rates, but lower acute rejection incidence. Senescence seems to result in shift to memory profile and…
  • 2017 American Transplant Congress

    Characterization of a B Lymphocyte Signature Predictive of Chronic Lung Allograft Dysfunction.

    C. Brosseau,1,2 M. Durand,1,2 E. Durand,1,2 J. Loy,2 A. Foureau,2 P. Lacoste,2 P.-J. Royer,2 A. Magnan,2 S. Brouard.1

    1INSERM UMR1064, Centre de Recherche en Transplantation et, Nantes, France; 2INSERM UMR1087, Institut du Thorax, Nantes, France

    The occurrence of chronic lung allograft dysfunction (CLAD) is the main complication after lung transplantation (LT) and remains the most common cause of graft failure…
  • 2017 American Transplant Congress

    ABO-Incompatibility Using Ritiuximab Does Not Increase Hepatocellular Carcinoma Recurrence After Liver Transplantation.

    J. Kim, S. Kim, J. Lee, K.-S. Kim, J. Lee, G.-S. Choi, J. Park, C. Kwon, J.-W. Joh, S.-K. Lee.

    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Background and aims: ABO-incompatible (ABO-I) living donor liver transplantation (LDLT) has a high success rate. However, a difference in hepatocellular carcinoma (HCC) recurrence rates has…
  • 2017 American Transplant Congress

    CD4 T Cells and Co-Engagement with Foreign Protein Are Required in Antibody Response to Non-Self Blood Group A-Antigen.

    I. Adam, B. Motyka, L. West.

    Micro & Immunology, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada; Pediatrics, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada; Pediatrics, Surgerey, and Immunology, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada

    Background: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. B-cell tolerance develops to donor A/B-antigen(s) (Ag) after ABOi HTx…
  • 2017 American Transplant Congress

    CXCL13 as a New Systemic Biomarker for B-Cell Involvement in Acute Kidney Allograft Rejection.

    L. Schiffer,1 F. Wiehler,1 M. Daemmrich,2 K. Hueper,3 M. Mengel,4 A. Thorenz,1 S. von Vietinghoff,1 R. Song,1 M. Schiffer,1 F. Gueler.1

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Pathology, Hannover Medical School, Hannover, Germany; 3Radiology, Hannover Medical School, Hannover, Germany; 4Laboratory Medicine & Pathology, University of Alberta, Edmonton, Canada

    The majority of kidney allograft rejections are T cell mediated (TCMR). However, it has been shown that in the presence of B-cell clusters the course…
  • 2017 American Transplant Congress

    B Cell-Derived Cytokines Rather Than T/B Cognate Interactions Mediate CD8 T Cell Reconstitution Following Lymphoablation.

    D. Zwick, K. Ayasoufi, R. Fan, V. Gorbacheva, K. Keslar, R. Fairchild, A. Valujskikh.

    Immunology, Cleveland Clinic, Cleveland, OH

    Antibody-mediated lymphoablation is a commonly used induction therapy in sensitized transplant recipients. Using murine anti-thymocyte globulin (mATG) in a model of BALB/c (H-2d) to B6…
  • 2017 American Transplant Congress

    Pre-Transplant HLA-Specific B Cell Breadth of Reactivity in a Novel Multiplex Bead-Based Assay Predicts Rejection in Kidney Transplant Recipients.

    Z. Ilyas,1 A. Aki,1 A. Tambur,1 P. Heeger,2 M. Ansari.1

    1Northwestern University, Chicago; 2Icahn School of Medicine at Mount Sinai, New York

    Introduction: Recipients with broad sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) are at higher immunologic risk for poor graft…
  • 2017 American Transplant Congress

    Assessment of Cardiosphere-Derived Cell Exosomes as Possible Modulator of Alloimmunity in a Mouse Model of HLA-A2 Allosensitization.

    I. Kim,1 G. Wu,1 N.-N. Chai,1 G. De Couto,2 E. Marban,2 A. Klein,1 S. Jordan.1

    1Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; 2Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA

    Purpose: Mounting data indicate that exosomes, a nanosized membrane particle secreted by cells has immune regulatory properties, including anti-inflammation and mediating autocrine, paracrine, and endocrine…
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