2017 American Transplant Congress
Antibody Mapping by Protein Microarray Revealed a Unique Repertoire in Lung Transplant Recipients That Developed Chronic Lung Allograft Dysfunction.
Background: Development of chronic lung allograft dysfunction (CLAD) limits long-term success from lung transplantation (LTx). Elicitation of de novo antibody (Ab) to mismatched donor HLA…2017 American Transplant Congress
Percentage of CD19+ B Cells as a Predictor of Acute Antibody-Mediated Rejection After Administration of Rituximab in ABO-Incompatible Kidney Transplantation.
Urology, Hokkaido University, Sapporo, Japan
[Introduction] Administration of rituximab to ABO-incompatible kidney transplant (ABOi-KTx) recipients is recognized as effective and safe. A single dose of 375 mg/m2 rituximab is generally…2017 American Transplant Congress
A Novel Role for MyD88 Signaling Downstream from Toll-Like Receptors in B Cells Responding to Blood Group Antigens.
Hiroshima University, Hiroshima, Japan
[Introduction]Although there is some empirical evidence that severe infectious complications provoke refractory AMR following ABO-incompatible transplantations (ABOi-Tx), its mechanism remains unclear. Here, we investigated a…2017 American Transplant Congress
TFR:TFH Cell Ratio Correlates with Anti-Donor Germinal Center Reactivity and Donor-Specific Antibody Formation Following Transplantation.
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA
Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Although short-term outcomes are excellent, long-term allograft survival rates remain inadequate. It…2017 American Transplant Congress
Outcome of ABO-Incompatible Kidney Transplantation After Stratified Desensitization.
Background. Plasmapheresis for antibody removal and rituximab for antibody production suppression are performed for desensitization against ABO-incompatible kidney transplantation. We evaluated clinical outcome for optimizing…2017 American Transplant Congress
Expansion, Function and Clonotypic Analysis of Human Alloreactive Treg Stimulated with Different Dendritic Cell Populations or CD40L-Stimulated B Cells.
Purpose:In order to establish a protocol to generate large numbers of human alloantigen-reactive regulatory T cells (arTreg) with potent allospecific suppressive capacity for therapeutic application,…2017 American Transplant Congress
Strategy for Analysis of Donor-Specific Antibody Repertoire: Paired Immunoglobulin Heavy and Light Chain Analysis of Individual Memory B Cells.
Antibody-mediated rejection (ABMR) is the most challenging immunological barrier to overcome in human transplantation and one of the most prevalent causes of kidney allograft loss.…2017 American Transplant Congress
Human Transitional B Cell Cytokine Profile Predicts Renal Allograft Rejection and Clinical Course.
In Kidney Transplant Recipients (KTRs), non-invasive predictive biomarkers that allow early intervention are limited. Here we report findings from a prospective longitudinal study using B…2017 American Transplant Congress
CD8+ TAb-supp Cells Are Key Inhibitors of Humoral Alloimmunity by Inhibiting CD4+TFH Cells and Killing Germinal Center B Cells.
Surgery, The Ohio State University Wexner Medical Center, Columbus, OH
Alloantibodies (alloAb) play a critical role in acute and chronic rejection after transplantation (Tx). It is well known that CD4+ T cells and B cells…2017 American Transplant Congress
B Cell Deficiency Inhibits Both Antibody Mediated Rejection and T Cell Mediated Acute Rejection in a Rat Kidney Transplant Model.
University of Wisconsin, Madison, WI
Purpose: The specific role of B cells in the pathogenesis of acute rejection remains unclear.Methods: To address this question, we generated B cell deficient Lewis…
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