Articles tagged "B cells"

2019 American Transplant Congress
Novel In Vitro Germinal Center Culture System Demonstrates More Aggressive B Cell to Plasma Blast Differentiation in Allosensitized Nonhuman Primates
P. Schroder, J. Yoon, R. Schmitz, Z. Fitch, J. Kwun, S. J. Knechtle
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: The allogeneic humoral immune response is largely composed of T cell dependent antibody responses produced after B and T cells interact within the germinal…
2019 American Transplant Congress
Anti CD45RB Antibody Therapy Attenuates Renal Ischemia Reperfusion Injury by Inducing Regulatory B Cells
S. Lee¹, S. Park¹, J. Hwang¹, J. Ryu², T. Koo², C. Ahn², J. Yang³
¹Biomedical Research Institute, Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of surgery, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Regulatory B cells (Bregs) are a new B cell subset that suppresses immune responses. Recently, both anti-CD45RB and anti-Tim-1 treatments have been found to…
2019 American Transplant Congress
TACI Polymorphisms Associated with Increased Alloimmunity and Allograft Rejection
M. Garcia de Mattos-Barbosa¹, E. A. Farkash², J. L. Platt¹, M. Cascalho¹
¹Transplant Surgery, University of Michigan, Ann Arbor, MI, ²Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Transmembrane activator and CAML interactor (TACI) controls B cell differentiation. The TACI gene is highly polymorphic (>95% of all genes) and frequently variants exhibit…
2019 American Transplant Congress
Epstein Barr Virus DNA Integration in B Cell Lymphomas of Post-Transplant Lymphoproliferative Disorder
M. C. McPherson, O. M. Martinez
Surgery, Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA
*Purpose: Epstein Barr virus-positive (EBV+) B cell lymphomas can arise in immunosuppressed individuals, such as organ transplant recipients in the context of post-transplant lymphoproliferative disorder…
2018 American Transplant Congress
The Incidence of Polyomavirus-BK and Cytomegalovirus Infections in Renal Transplant Recipients Following Rituximab Administration
A. Kraljevic, C. D'Agostino, C. Kane, K. Cunningham, A. Shetty, C. Richardson.
Northwestern Memorial Hospital, Chicago, IL.
Rituximab is an antibody that binds to the CD20 antigen on B cells resulting in rapid and prolonged depletion. At Northwestern Memorial Hospital, a single…
2018 American Transplant Congress
Impact of De Novo DSA (DnDSA) on Outcomes in HLA-Sensitized (HS) Patients Transplanted after IVIG + Rituximab Desensitization (DES)
A. Vo,¹ O. Aubert,² H. Edmund,¹ A. Peng,¹ R. Najjar,¹ S. Supreet,¹ J. Choi,¹ K. Lim,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; ²Paris Translational Research Center for Organ Transplantation, Necker Hospital, Paris, France.
Introduction: Highly-HLA sensitized patients (HS) with donor specific antibodies (DSA) at transplant are at risk for Type 1 ABMR. However, the incidence of Type 2…
2018 American Transplant Congress
TACI Polymorphisms Associated with Allograft Rejection in Mice and in Man
M. Barbosa,¹ E. Farkash,² J. Platt,³ M. Cascalho.³
¹Surgery, University of Michigan, Ann Arbor, MI; ²Pathology, University of Michigan, Ann Arbor, MI; ³Surgery/Microbiology and Immunology, University of Michigan, Ann Arbor, MI.
Trans-membrane Activator and CAML Interactor (TACI) controls B cell differentiation and memory and exists as numerous allelic variants in healthy individuals. In fact, TACI is…
2018 American Transplant Congress
Prolonged Cold Ischemia Storage of Renal Allografts Shifts DSA Specificity and Enchances Glomerular Injury
V. Gorbacheva, R. Fan, W. Baldwin, A. Valujskikh.
Immunology, Cleveland Clinic, Cleveland, OH.
Prolonged cold ischemia storage (CIS) of donor organs is a major risk factor for acute and chronic graft injury. The goal of this study was…
2018 American Transplant Congress
Elevated Levels of CD19⁺ B Cells before or after Rituximab Administration is a Risk Factor for the Early Rejection of a Living Kidney Transplant
M. Kono,¹ H. Shirakawa,² S. Wakai.¹
¹Nephrology, Ohkubo Hospital, Tokyo, Japan; ²Urology, Ohkubo Hospital, Tokyo, Japan.
[Introduction]Rituximab (RTX) is used for desensitization in highly sensitized patients, such as those undergoing ABO-incompatible (ABOi) kidney transplantation. Although RTX is generally effective, some patients…
2018 American Transplant Congress
In Vivo Administration of Plerixafor and Bortezomib Results in Bone Marrow Plasma Cell Mobilization and Death While Inducing Biphasic Plasma Cell Apoptosis in Peripheral Blood
E. Woodle,¹ S. Tremblay,¹ C. Castro-Rojas,² S. Knechtle,³ A. Shields,¹ R. Alloway,¹ H. Singh,² J. Driscoll,¹ D. Hildeman.²
¹U Cincinnati, Cincinnati; ²Cincinnati Children's, Cincinnati; ³Duke, Durham.
Bone marrow (BM) plasma cells (PC) secreting HLA antibody (Ab) remain a persistent reservoir of donor specific Ab and present a significant hurdle to allograft…