ATC Abstracts

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Articles tagged "B cells"

  • 2019 American Transplant Congress

    B Cell Derived Exosomes Are Associated with Antibody Mediated Rejection in Kidney Transplant Recipients Desensitized for a Positive Cross-Match

    D. Cucchiari1, V. Tubita2, M. J. Ramirez-Bajo2, J. Rovira2, F. E. Borràs3, L. Carreras-Planella3, A. Hertig4, F. Oppenheimer1, F. Diekmann1, I. Revuelta1

    1Renal Transplant Unit, Hospital Clínic, Barcelona, Spain, 2Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain, 3REMAR-IVECAT group, IGTP, Badalona, Spain, 4Department of Nephrology and Kidney Transplantation, Hôpital Tenon, Paris, France

    *Purpose: Kidney transplant recipients undergoing desensitization for a positive cross-match are at very high risk of developing Antibody-Mediated Rejection (AMR). Because of desensitization, peripheral circulating…
  • 2019 American Transplant Congress

    Acquired Resistance to Transplantation Tolerance as a Result of Prior Pregnancy Requires B Cells

    D. V. Tran, A. N. Suah, S. Khiew, J. S. Young, Q. Wang, D. Yin, M. Alegre, A. S. Chong

    Departments of Surgery and Medicine, University of Chicago, Chicago, IL

    *Purpose: Clinical data suggest allogeneic pregnancy is a sensitizing event; however, data from mouse models suggests it induces fetal-specific regulatory T cell (Treg) expansion and…
  • 2019 American Transplant Congress

    Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection

    K. Abou-Daya, D. Zhao, A. Williams, M. Oberbarnscheidt

    Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
  • 2019 American Transplant Congress

    Effect of Everolimus on IgM and IgG Memory B Cell Growth and Survival In Vitro and Applications for Effective Administration in Clinical Practice

    Y. Matsuda

    Osaka University Graduate School of Medicine, Osaka, Japan

    *Purpose: Everolimus (EVR), which is converted from CNI, is reported to improve renal function and reduce renal toxicity, DSA production, and rejection development. However, there…
  • 2018 American Transplant Congress

    Impact of the New KAS on Transplant Rates in Highly-HLA Sensitized (HS) Patients after Desenstization (DES): 3yrs Post Implementation

    A. Vo, E. Huang, N. Ammerman, S. Williamson, C. Myers, A. Peng, R. Najjar, S. Sethi, K. Lim, S. Jordan.

    Kidney Transplant, Cedars-Sinai Medical Center, LA, CA.

    Introduction: The KAS aims to increase equity in organ allocation for broadly sensitized (HS) patients, especially (CPRA 99-100%). Coupling desensitization (DES) + KAS likely will…
  • 2018 American Transplant Congress

    IL-10 Requirement in In Vitro Expanded Breg-Mediated Allograft Tolerance is Tissue Specific

    C. Dai, K. Lee, L. Kojima, K. Deng, S. Kimura, C. Rickert, H. Yeh, J. Markmann.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.

    Introduction:Regulatory B cells (Bregs) have shown several multiple mechanisms of suppression, including Treg induction and IL-10 production. Consistent with work of other groups on Breg…
  • 2018 American Transplant Congress

    Increase on Regulatory Cells in Kidney Transplanted Patients Presenting Donor-Specific Antibodies

    G. Maciel,1 M. Fernandes,1,2 E. Barbosa,2 H. Rodrigues,1 N. Panajotopolus,1 F. Agena,2 E. David-Neto,2 V. Coelho,1 M. Castro.2

    1Laboratory of Immunology, São Paulo University, São Paulo, Brazil; 2Renal Transplantation Service, Clinical Hospital, São Paulo, Brazil.

    The role of anti-HLA donor specific antibodies (DSA) in increasing the risk of graft rejection is known. Nevertheless, not all patients with DSA develop rejection…
  • 2018 American Transplant Congress

    T Cell Exhaustion Contributes to Operational Tolerance of Liver Allografts in Pediatric Liver Transplant Recipients

    B. Ramaswami,1 M. Marrari,2 O. Yoshida,5 X. Guo,3 W. Hoffman,3 C. Bentlejewski,2 D. Metes,1 A. Demetris,1,2 A. Zeevi,2 A. Thomson,1 G. Mazariegos,4 G. Chalasani.1,3

    1Surgery, Starzl Transplantation Institute, Pittsburgh, PA; 2Pathology, University of Pittsburgh, Pittsburgh, PA; 3Medicine, University of Pittsburgh, Pittsburgh, PA; 4Children's Hospital, University of Pittsburgh, Pittsburgh, PA; 5Gastroenterology, Ehime University Graduate School of Medicine, Toon-shi, Ehime-ken, Japan.

    Operational tolerance in the absence of immunosuppression can be successfully attained in pediatric liver transplant recipients. Although DSA are observed in a proportion of operationally…
  • 2018 American Transplant Congress

    Achieving Allograft Tolerance through Antigen-Specific Regulatory B Cells

    C. Rickert,1,2 S. Kimura,1,2 L. Kojima,1 K. Lee,1 M. Aburawi,1 F. Fontan,1 K. Deng,1 H. Yeh,1,2 J. Markmann.1,2

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, MA.

    IntroductionA complete understanding of the role of antigen-specificity in the development of B cell mediated allograft tolerance has remained elusive. Previous work in our lab…
  • 2018 American Transplant Congress

    Accommodation and Antibody Mediated Rejection Are Associated with Distinct TACI Polymorphisms in Kidney Transplant Recipients

    M. Cascalho, M. Barbosa,1 E. Farkash,2 J. Platt.1

    1Surgery, University of Michigan, Ann Arbor, MI; 2Pathology, University of Michigan, Ann Arbor, MI.

    A. Trans-membrane Activator and CAML Interactor (TACI) gene is among the 5% most polymorphic genes in humans, TACI controls B cell differentiation and memory and…
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