Articles tagged "B cells"

2019 American Transplant Congress
Resolution of Hyperglycemia Following Islet Allograft Transplantation in Non-Immunosuppressed Mice
J. Ge¹, K. Lee¹, C. Yang¹, R. White², I. Rosales², P. Russell¹, C. Rickert¹, J. Markmann¹, J. Madsen¹, R. Colvin², A. Alessandrini¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: Kidney allografts are naturally tolerogenic in mice. Certain mouse strain combinations develop tolerance of kidney allografts across full MHC incompatibilities without immunosuppression (e.g. DBA/2…
2019 American Transplant Congress
Efficacy Of Rituximab Monotherapy On Anti-human Leukocyte Antigen Antibodies In Highly Sensitized Living Donor Kidney Transplant Patients.
D. J. Sindi¹, A. Al Jedai², H. Aleid³, J. Brockmann⁴, M. Al-Awwami⁵, D. Alissa², E. De Vol⁶, H. Al Khabbaz⁷, L. Fajji⁸
¹Clinical Pharmacy, King Faisal Specialist Hospital and Research Center (KFSH&RC), Riyadh, Saudi Arabia, ²Clinical Pharmacy, KFSH&RC, Riyadh, Saudi Arabia, ³Kidney and Pancreas transplantation, KFSH&RC, Riyadh, Saudi Arabia, ⁴kFSH&RC, Riyadh, Saudi Arabia, ⁵Clinical Director, Histocompatibility and Immunogenetics Laboratory, KFSH&RC, Riyadh, Saudi Arabia, ⁶KFSH&RC, Riyadh, Saudi Arabia, ⁷Riyadh Elm University, Riyadh, Saudi Arabia, ⁸Clinical Transplant Coordinator, KFSH&RC, Riyadh, Saudi Arabia
*Purpose: We aim to examine the efficacy of Rituximab (RTX) monotherapy in reducing DSA in Highly Sensitised Living Donor Kidney Transplant (HS-LDKT) candidates and potentially…
2019 American Transplant Congress
B Cell IL-4 Signaling Induces the IL-10 Secreting TIM-1+ Bregs and Suppresses T Cell Inflammatory Cytokines
Z. Song, K. Mohib, D. M. Rothstein
Surgery, Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: TIM-1+ identifies the majority (~75%) of IL-10+ B regulatory cells (Bregs). However, TIM-1+ B cells are also enriched for IL-4+ B effector 2 cells…
2019 American Transplant Congress
Combined Antithymocyte Globulin (ATG) and Rituximab (RTX) Induction in African American (AA) Kidney Transplant Recipients
S. J. Patel, S. Kuten, C. Pham, R. Knight, M. Hobeika, D. Nguyen, E. Graviss, S. Yi, T. Eagar, A. Gaber
Methodist Hospital, Houston, TX
*Purpose: We have previously shown that despite the use of T cell-depleting antibody induction, AA kidney transplant recipients (KTR) remain at high risk of rejection…
2018 American Transplant Congress
Donor-Specific B-Cell Tolerance after Successful ABO Blood Type Incompatible (ABOi) Living Donor Liver Transplantation (LDLT)
T-.J. Wu, Y-.C. Wang, C-.H. Cheng, T-.H. Wu, C-.F. Lee, H. Chou, K-.M. Chan, W-.C. Lee.
Division of Liver and Transplantation Surgery, Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Background/purposeABO blood type-incompatible (ABOi) liver transplantation is one of the strategies employed to overcome the shortage of donor. By using the Rituximab and plasm exchange,…
2018 American Transplant Congress
Prospective Multicenter Validation of Human Transitional B Cell Cytokines as a Predictive Biomarker in Renal Transplantation
A. Cherukuri,¹ D. Chittka,¹ A. Sharma,¹ A. Salama,² C. Magee,² D. Rothstein.¹
¹UPMC, Pittsburgh; ²UCL, London, United Kingdom.
In renal transplantation, non-invasive biomarkers are needed to identify patients at risk for poor outcomes and guide pre-emptive therapy. Here, we assessed B cell cytokines…
2018 American Transplant Congress
Reduction in Circulating CD19⁺CD24⁺CD27⁺ Regulatory B Cell Frequency Predicts Acute Rejection in Liver Transplant Patients
H. Zhou, Z. Rao, Y. Lu, J. Rao, J. Gu, L. Lu, Y. Xia.
Liver Transplant Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Accumulating evidence suggests that regulatory B cells (Bregs) play an important role in modulating inflammation and autoimmune diseases. However, whether Bregs regulate acute liver…
2018 American Transplant Congress
TACI-Ig as a Desensitization Agent in a Rat Model of Antibody Mediated Rejection
N. Wilson,¹ B. Verhoven,² B. Boldt,² N. Bath,² X. Ding,¹ R. Redfield III.²
¹Medicine/Nephrology, University of Wisconsin, Madison, WI; ²Surgery/Transplant, University of Wisconsin, Madison, WI.
We examined the effect of APRIL/BLyS blockade on B cell lineages & donor specific antibody (DSA) in preclinical rodent model as a novel desensitization strategy.…
2018 American Transplant Congress
Prevention of an Adaptive Immune Response by FDA-Approved Immunosuppressive Agents in Baboons with Pig Artery Patch Xenografts
T. Yamamoto,¹ H. Hara,¹ L. Wang,¹ Q. Li,¹ J. Li,¹ H. Zhou,¹ D. Eckhoff,¹ A. Tector,¹ D. Ayares,² D. Cooper,¹ H. Iwase.¹
¹Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham; ²Revivicor, Blacksburg.
Background: In the pig-to-baboon artery patch model with no immunosuppressive therapy, a graft from a GTKO pig elicits a significant anti-nonGal IgG response, indicating sensitization…
2018 American Transplant Congress
Ex Vivo-Expanded Human CD19⁺CD73^–CD25⁺CD71⁺TIM-1⁺ B Regulatory Cells Can Prolong Allograft Survival in a Humanized Mouse Model of Skin Transplantation and Are Dependent on TIM-1-Mediated Regulation of STAT3 Signaling
S. Shankar,¹ J. Stolp,^1,2 S. Juvet,^1,3 J. Hester,¹ K. Wood.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Garvan Institute of Medical Research, Sydney, Australia; ³Toronto General Hospital Research Institute, Toronto, Canada.
The importance of B regulatory cells (Breg) in both health and disease has rapidly become evident over the last decade. Breg are able to control…