2020 American Transplant Congress
Effect of Rituximab Dose as Induction Therapy in ABO Incompatible Living Kidney Transplantation A Systemic Review and Network Meta Analysis
1Inha University, Incheon, Korea, Republic of, 2Keimyung University, Daegu, Korea, Republic of
*Purpose: ABO-incompatible living kidney transplantation (ABOILKT) has steadily become more widespread. However, the optimal immunosuppressive regimen for ABOILKT remains uncertain. We aimed to determine the…2020 American Transplant Congress
Recipient LAG3 Deficiency Results in Antibody-Mediated Rejection of Mouse Renal Allografts
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Lymphocyte activation gene-3 (LAG3) is a coinhibitory receptor on the surface of T and B lymphocytes, NK cells and plasmacytoid dendritic cells. Its functions…2020 American Transplant Congress
BAFF Inhibition to Prevent Antibody Rebound Following Proteasome Inhibitor-Based Desensitization: A Randomized, Controlled Trial
*Purpose: Proteasome inhibitor (PI) therapy reduces bone marrow plasma cells and HLA antibodies (Abs) in renal transplant candidates. However, rebound is common in many patients…2020 American Transplant Congress
Immune Cell Subset Profiles in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)
*Purpose: IL-6, B cell growth factor, increases follicular T helper cell (Tfh) activity, promoting plasmablast (PB) and plasma cell (PC) differentiation, and antibody production. A…2020 American Transplant Congress
Investigation of Il35 Expressing Regulatory B Cells in Tolerance of Kidney Transplantation
Surgery, University of Wisconsin, Madison, WI
*Purpose: The development and maintenance of peripheral tolerance is required for long term success of solid organ transplantation without immuno-suppressive drugs. Using a novel, post-transplant,…2019 American Transplant Congress
Decay Accelerating Factor (DAF) Regulates Germinal Center B-cell and Alloantibody Formation
*Purpose: High affinity IgG antibodies including alloantibodies result from germinal center (GC) reactions in which somatic hypermutation and positive selection cause affinity maturation. When we…2019 American Transplant Congress
B Cell Derived Exosomes Are Associated with Antibody Mediated Rejection in Kidney Transplant Recipients Desensitized for a Positive Cross-Match
*Purpose: Kidney transplant recipients undergoing desensitization for a positive cross-match are at very high risk of developing Antibody-Mediated Rejection (AMR). Because of desensitization, peripheral circulating…2019 American Transplant Congress
Acquired Resistance to Transplantation Tolerance as a Result of Prior Pregnancy Requires B Cells
Departments of Surgery and Medicine, University of Chicago, Chicago, IL
*Purpose: Clinical data suggest allogeneic pregnancy is a sensitizing event; however, data from mouse models suggests it induces fetal-specific regulatory T cell (Treg) expansion and…2019 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…2019 American Transplant Congress
Effect of Everolimus on IgM and IgG Memory B Cell Growth and Survival In Vitro and Applications for Effective Administration in Clinical Practice
Osaka University Graduate School of Medicine, Osaka, Japan
*Purpose: Everolimus (EVR), which is converted from CNI, is reported to improve renal function and reduce renal toxicity, DSA production, and rejection development. However, there…
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