2020 American Transplant Congress
Humoral Sensitization Overrides Pregnancy-Induced T Cell Transplantation Tolerance
*Purpose: There are ample clinical data that a major long-term consequence of pregnancy is humoral allosensitization. Paradoxically, pregnancy is also a state of spontaneous allogeneic…2020 American Transplant Congress
Irf8-Relevant Mechanism in B Cell Regulation In Vitro
*Purpose: Previously, we had reported that IFN regulatory factor 8 (IRF8) could be used for the identification of interstitial fibrosis and tubular atrophy (IFTA) with…2020 American Transplant Congress
Single Cell Gene Profiling Highlights Novel B Cell Populations Associated with the Development of Bronchiolitis Obliterates Syndrome after Lung Transplantation
*Purpose: The occurence of bronchiolitis obliterans syndrome (BOS) accounts for a poor long term prognosis after lung transplantation (LTx). Despite immunosuppressive T cell-targeting therapies the…2020 American Transplant Congress
New Everolimus Administration Targeting the Prevention of the Development of Antibody-Mediated Rejection Considering the Comparison of Growth and Survival in IgG and IgM Memory B Cells
*Purpose: Some reports indicated that immunoglobulin (Ig) M antibodies corresponding to donor-specific antigen in addition to IgG antibodies are closely involved in the activation of…2020 American Transplant Congress
HLA-Antibody Develops Preferentially in Healthy Subjects with a T-bethiB Cell Response to Vaccine
University of Alabama, Birmingham, AL
*Purpose: Bystander B cell differentiation into antibody (Ab) secreting cells (ASCs) may augment alloimmunity in the HLA-sensitized patient. Recently, a population of FcrL5+IgDnegB cells that…2019 American Transplant Congress
Costimulation Blockade Modulates Humoral Responses in Highly Sensitized Transplant Recipients
Surgery, Duke Transplant Center, Durham, NC
*Purpose: Broad human leukocyte antigen sensitization is a significant barrier to successful solid organ transplantation. Sensitized patients have poor access to donor organs, high wait…2019 American Transplant Congress
IL-1β and IL-6 Facilitate T Cell Reconstitution in Heart Allograft Recipients Treated with Anti-Thymocyte Globulin
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Antibody-mediated lymphocyte depletion is used in solid organ and stem cell transplantation. However, T cell reconstitution after lymphoablation may lead to acute rejection and…2019 American Transplant Congress
IL-10+ Plasma Cells Are Not Required for Breg Activity and Are Counterbalanced by Novel Pro-Inflammatory Plasma Cells
University of Pittsburgh, Pittsburgh, PA
*Purpose: Classically, B cells differentiate into Ab-secreting plasma cells (PCs; B220lowCD138hiBlimp1+Ig+) providing humoral immunity. B cells can also inhibit or promote immune responses through the…2019 American Transplant Congress
Regulation of Host microRNA Expression by Natural Variants of Epstein Barr Virus (EBV) Latent Membrane Protein 1 (LMP1)
*Purpose: Malignancies attributable to EBV, such as post-transplant lymphoproliferative disorder (PTLD), represent 1.8% of global cancer deaths. PTLD occurs in 1-20% of transplant recipients and…2019 American Transplant Congress
Interleukin-27 is Required for Donor Specific Antibody Production in Response to Heart Allograft Transplantation
Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Interleukin-27 (IL-27), a member of IL-12 cytokine family, is involved in both pro- and anti-inflammatory immune responses. Previously we reported that B cell derived…
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