Articles tagged "B cells"

2020 American Transplant Congress
A Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events in Kidney Transplant Recipients
F. Bouchard-Boivin, O. Désy, S. Béland, S. De Serres
Transplantation Unit, Renal Division, Medecine Department, Laval University, Québec, QC, Canada
*Purpose: No clinical tool is available to dynamically access immunosuppression status, which results in serious, often life-threatening adverse effects of immunosuppressants. We recently validated that…
2020 American Transplant Congress
Naïve B Cells Regulation by TLR-Breg Cells In Vitro
Q. Fu, K. Lee, G. Huai, K. Deng, N. J. Feeney, C. Leguern, S. Deng, J. F. Markmann
Center for Transplant Science, MGH, Boston, MA
*Purpose: Regulatory B cells (Bregs) have shown great potential in cell therapies for murine organ transplantation by inhibiting the proliferation of cytotoxic and helper T…
2020 American Transplant Congress
Transplant Monitoring and PTLD Detection with B Cell Receptor Repertoire Analysis in a Large Prospective Pediatric Cohort
K. Jackson¹, O. Martinez², S. Krams², M. Robien³, M. Lapasaran², B. Armstrong⁴, C. Twist⁵, K. Weinberg⁶, D. Gratzinger¹, B. Tam¹, M. Sever⁴, M. Brown³, D. Bernstein⁶, C. Esquivel², S. D. Boyd¹
¹Department of Pathology, Stanford Univ School of Med, Stanford, CA, ²Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, ³NIAID, NIH, Bethesda, MD, ⁴Rho, Chapel Hill, NC, ⁵Roswell Park, Buffalo, NY, ⁶Department of Pediatrics, Stanford Univ School of Med, Stanford, CA
*Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is a…
2020 American Transplant Congress
Donor-Specific B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Graft Failure in Kidney Transplant Recipients
Z. Ilyas, A. Akl, D. Pinelli, L. Gallon, A. R. Tambur, M. Ansari
Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Kidney transplant recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at…
2020 American Transplant Congress
Sex and ABO Antibodies: High-Level Natural ABO Antibody Production and IgM to IgG Class Switch in Female vs. Male Mice
B. Anjum, B. Motyka, I. Adam, J. Fersovich, M. Sulzer, J. Pearcey, K. Tao, L. J. West
Dept Pediatrics, Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada
*Purpose: ABO histo-blood group incompatibility is a barrier in solid organ transplant due to the presence of ‘natural’ preformed ABO antibodies. However, ABO-incompatible (ABOi) heart…
2019 American Transplant Congress
Alloreactive B Cells in Transplant Tolerant Recipients Cannot Differentiate into Antibody-Secreting Cells but Can Suppress Donor-Specific IgG Production By Naïve B Cells
S. H. Khiew¹, J. Chen¹, D. Jain¹, Q. Wang¹, D. Yin¹, M. Alegre², A. S. Chong¹
¹Department of Surgery, Section of Transplant, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Donor specific transplantation tolerance has long been the goal of clinical transplantation. Clinical observations suggest that donor-specific antibodies (DSA) are a major cause of…
2019 American Transplant Congress
Rituximab Protects against Development of Atherosclerotic Cardiovascular Disease after Kidney Transplantation, a Propensity Matched Analysis
D. Kim, J. Lee, J. Lee, B. Kim, M. Kim, S. Soon Il, Y. Kim, K. Huh, S. Kim, D. Joo, K. In, E. Kim
Severance hospital, Seoul, Korea, Republic of
*Purpose: Recent studies have implicated B cells in atherosclerosis and have verified the atheroprotective effect of rituximab. We sought to explore the effects of rituximab…
2019 American Transplant Congress
RNA Sequencing Guided Identification of Shared mRNAs in Human Kidney Allograft Recipients with Acute T Cell Mediated Rejection or Active Antibody Mediated Rejection
B. Dooley¹, A. Verma², R. Ding¹, C. Li¹, C. Snopkowski¹, H. Yang¹, B. Botticelli¹, S. Albakry¹, E. Edusei¹, T. Muthukumar¹, M. Lubetzky¹, D. Dadhania¹, J. Lee¹, O. Elemento², M. Suthanthiran¹
¹Transplantation Medicine, Weill Cornell Medical College, New York, NY, ²Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY
*Purpose: T cell help is essential for B cell production of antibodies to donor organ HLA. Because T cell-B cell interactions contribute to anti-allograft immunity,…
2019 American Transplant Congress
Cellular And Molecular Characteristics Of Intra-graft Lymphoid Aggregates In Chronic Lung Allograft Dysfunction
E. Miyamoto¹, S. Juvet¹, D. Hwang², S. Keshavjee¹, T. Martinu¹
¹Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada, ²Sunnybrook Health Sciences Centre, Toronto, ON, Canada
*Purpose: Lymphoid aggregates (LAs) have been identified within lung allografts post lung transplant (LTx). However, it remains controversial whether they represent benign lymphoid tissue or…
2019 American Transplant Congress
Natural Anti-a Antibody Production In Mice Is Cd4 T Cell-independent
I. Adam¹, B. Motyka², L. West³
¹Medical Microbiology & Immunology, University of Alberta, Edmonton, AB, Canada, ²Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Pediatrics, Surgery, Immunology, Lab Medicine & Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada
*Purpose: ABO-incompatible organ transplants (ABOi-Tx) are at high risk of rapid rejection mediated by preformed ABO antibodies (Ab) except during infancy when they are absent.…