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American Transplant Congress abstracts

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Articles tagged "Autoimmunity"

  • 2019 American Transplant Congress

    Development of Non-Human Leukocyte Antigen Antibodies in Cardiac Antibody-Mediated Rejection

    S. B. See1, B. S. Mantell2, K. J. Clerkin3, B. Ray4, E. R. Vasilescu5, C. Marboe5, Y. Naka6, S. Restaino1, P. C. Colombo3, L. J. Addonizio2, M. A. Farr3, E. Zorn1

    1Columbia Center for Translational Immunology, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Division of Cardiology, Columbia University, New York, NY, 4Immucor, Georgia, GA, 5Department of Pathology and Cell Biology, Columbia University, New York, NY, 6Department of Surgery, Columbia University, New York, NY

    *Purpose: Antibody-mediated rejection (AMR), mainly driven by the development of donor-specific antibodies (DSA) directed against mismatched donor class I and class II HLA, is a…
  • 2019 American Transplant Congress

    Ischemic Preconditioning Attenuates Renal Ischemia-Reperfusion Injury through Activating the Nrf2/HO-1 Pathway Enhanced Autophagy

    H. Choi1, Y. Kim2, M. Kim2, K. Jun2, S. Kim2, S. Park3, J. Kim4, I. Moon5, J. Hwang6

    1Clinical Research Center, Daejeon St. Mary's Hospital, Daejeon, Korea, Republic of, 2Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 3Transplant Surgery, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, 4Transplant Surgery, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea, Republic of, 5Transplant Surgery, Yeouido St. Mary's Hospital, Seoul, Korea, Republic of, 6Transplant Surgery, Daejeon St. Mary's Hospital, Daejeon, Korea, Republic of

    *Purpose: Ischemic preconditioning (IPC), which is a brief and nonlethal episode of ischemia, confers protection against subsequent ischemia-reperfusion (I/R) through the up-regulation of endogenous protective…
  • 2019 American Transplant Congress

    Use of Anti-Vimentin Antibodies as a Possible Marker for Graft Dysfunction Following Renal Transplant, a Prospective Study

    E. Acosta1, T. Divanyan1, D. Patel1, F. Jourd'heuil2, D. Jourd'heuil2, R. Lopez-Soler3

    1Albany Medical College, Albany, NY, 2Molecular and Cellular Physiology, Albany Medical College, Albany, NY, 3Surgery, Section of Transplantation, Albany Medical College, Albany, NY

    *Purpose: In our previously published work, we showed that presence of anti-vimentin antibodies (AVA) after renal transplant correlated with early IFTA (Interstitial Fibrosis and Tubular…
  • 2019 American Transplant Congress

    Differential Diagnosis of Membranous Nephropathy Occurs after Bone Marrow Transplantation and Renal Transplantation

    L. Guo1, H. Wang1, Y. Tan2, J. Shen1, R. Wang1, J. Wu1, J. Chen1

    1Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China, 2First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Membranous nephropathy (MN), considered as a rare autoimmune kidney disease, often occurs in synchronization with manifestation of chronic graft-versus-host disease after transplantation. After bone…
  • 2019 American Transplant Congress

    Liver Transplantation in Children with Type 1 and Type 2 Autoimmune Hepatitis

    I. G. Roepe, J. A. Goss, T. Miloh

    Department of Student Affairs, Baylor College of Medicine, Houston, TX

    *Purpose: Autoimmune Hepatitis (AIH) can be defined as type 1 and type 2 based on autoantibodies. Liver transplant (LT) may be indicated for chronic liver…
  • 2019 American Transplant Congress

    Variable Outcomes of Recurrent Autoimmune Diabetes Post Pancreas Transplant Treated with Rituximab

    K. Venkatachalam, A. Markwardt, B. Heady, T. Alhamad, A. Malone

    Washington University, St. Louis, MO

    *Purpose: Demonstrate the outcomes of treatment with rituximab in patients with autoimmune diabetes after pancreas transplant.*Methods: We present the treatment response to rituximab in 3…
  • 2019 American Transplant Congress

    Circulating Exosomes with Cardiac Self-Antigens (Cardiac Myosin and Vimentin) and De Novo Development of Antibodies to Cardiac Self-Antigens Precedes Chronic Cardiac Allograft Rejection

    R. Ravichandran, Y. Itabashi, W. Liu, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: The aim of the study is to determine the kinetics of induction of circulating exosomes with cardiac self-antigens (SAgs), cardiac myosin (MYO) and Vimentin…
  • 2019 American Transplant Congress

    Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy

    M. Ma, P. Chhabra, K. Brayman

    Surgery, University of Virginia, Charlottesville, VA

    *Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
  • 2018 American Transplant Congress

    An Open-Label Proof-of-Principle Phase 2a Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)

    A. Chruscinski,1 H. Atkins,2 M. Macarthur,1 C. Anne Marie,2 D. Grant,1 C. Bredsen,2 E. Renner,1 L. Lilly,1 N. Selzner,1 O. Adeyi,1 R. Smith,1 S. Moshkelgosha,1 A. Humar,1 S. Juvet,1 G. Levy.1

    1Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; 2Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.

    Background: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
  • 2018 American Transplant Congress

    Elevated Skin Specific Non-HLA Antibodies Correlate with Acute Rejection Episodes in Clinical VCA

    B. Kollar,1 A. Uffing,2 T. Win,1 S. Tasigiorgos,1 B. Pomahac,1 F. Quintana,3 L. Riella.2

    1Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA; 2Transplantation Research Center, Brigham and Women's Hospital, Boston, MA; 3Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA.

    Introduction: Vascularized composite allotransplantation (VCA) is unique by presence of the skin in the allografts. Due to the high immunogenicity of skin and the presence…
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