ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Autoimmunity"

  • 2019 American Transplant Congress

    Differential Diagnosis of Membranous Nephropathy Occurs after Bone Marrow Transplantation and Renal Transplantation

    L. Guo1, H. Wang1, Y. Tan2, J. Shen1, R. Wang1, J. Wu1, J. Chen1

    1Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China, 2First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Membranous nephropathy (MN), considered as a rare autoimmune kidney disease, often occurs in synchronization with manifestation of chronic graft-versus-host disease after transplantation. After bone…
  • 2019 American Transplant Congress

    Liver Transplantation in Children with Type 1 and Type 2 Autoimmune Hepatitis

    I. G. Roepe, J. A. Goss, T. Miloh

    Department of Student Affairs, Baylor College of Medicine, Houston, TX

    *Purpose: Autoimmune Hepatitis (AIH) can be defined as type 1 and type 2 based on autoantibodies. Liver transplant (LT) may be indicated for chronic liver…
  • 2019 American Transplant Congress

    Variable Outcomes of Recurrent Autoimmune Diabetes Post Pancreas Transplant Treated with Rituximab

    K. Venkatachalam, A. Markwardt, B. Heady, T. Alhamad, A. Malone

    Washington University, St. Louis, MO

    *Purpose: Demonstrate the outcomes of treatment with rituximab in patients with autoimmune diabetes after pancreas transplant.*Methods: We present the treatment response to rituximab in 3…
  • 2019 American Transplant Congress

    Circulating Exosomes with Cardiac Self-Antigens (Cardiac Myosin and Vimentin) and De Novo Development of Antibodies to Cardiac Self-Antigens Precedes Chronic Cardiac Allograft Rejection

    R. Ravichandran, Y. Itabashi, W. Liu, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: The aim of the study is to determine the kinetics of induction of circulating exosomes with cardiac self-antigens (SAgs), cardiac myosin (MYO) and Vimentin…
  • 2019 American Transplant Congress

    Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy

    M. Ma, P. Chhabra, K. Brayman

    Surgery, University of Virginia, Charlottesville, VA

    *Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
  • 2019 American Transplant Congress

    Decline in Club Cell Secretory Protein Results in Immune Responses to Lung Self-Antigens (Kα1 Tubulin and Collagen V) and Development of Chronic Rejection Following Human Lung Transplantation

    Y. Itabashi1, R. Ravichandran1, M. Sharma1, R. Hachem2, R. Bremner1, M. Smith1, T. Mohanakumar1

    1Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, 2Washington University School of Medicine, St. Louis, MO

    *Purpose: Club cell secretory protein (CCSP) levels have been employed as a biomarker for respiratory stress in athletes, asthma patients, and in experimental acute and…
  • 2019 American Transplant Congress

    Treg Plasticity is Induced by ENV,HERV1_I and UPR Activation in De Novo Autoimmune Hepatitis

    J. Yao1, A. Ling1, A. Arterbery1, Y. Avitzur2, S. Lobritto3, M. Martinez3, U. Ekong1

    1Yale University, New Haven, CT, 2University of Toronto, Toronto, ON, Canada, 3Columbia University, New York, NY

    *Purpose: FOXP3+regulatory T cells (Tregs) are not a terminally differentiated population & can, under specific environmental conditions, acquire the phenotype of effector T cells. We…
  • 2019 American Transplant Congress

    Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation

    S. Kanangat1, I. Kurbegovic-Skaljic2, D. Cimbaluk2, M. Oppermann2, S. Jensik3, E. Hollinger3, O. Olaitan4, R. DeCresce2

    1Tumor Immunology, NIH/NCI Bethesda MD,USA, Bethesda, MD, 2Pathology, Rush University Medical Center, Chicago, IL, 3Surgery, Rush University Medical Center, Chicago, IL, 4Tumor Immunology, Rush University Medical Center, Chicago, IL

    *Purpose: According to the latest Banff’s criteria approved in 2003, antibody mediated rejections following renal transplantation are divided into 2 types namely C4d + and…
  • 2018 American Transplant Congress

    Elevated Skin Specific Non-HLA Antibodies Correlate with Acute Rejection Episodes in Clinical VCA

    B. Kollar,1 A. Uffing,2 T. Win,1 S. Tasigiorgos,1 B. Pomahac,1 F. Quintana,3 L. Riella.2

    1Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA; 2Transplantation Research Center, Brigham and Women's Hospital, Boston, MA; 3Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA.

    Introduction: Vascularized composite allotransplantation (VCA) is unique by presence of the skin in the allografts. Due to the high immunogenicity of skin and the presence…
  • 2018 American Transplant Congress

    Prevention and Reversal of Diabetes through Restoration of B and T Cell Regulation and Immune Homeostasis

    K. Brayman,1 P. Chhabra,1 C. Wilson,2 A. Marshall,2 D. Moore.2

    1Surgery, University of Virginia, Charlottesville, VA; 2Pediatric Endocrinology, Vanderbilt University, Nashville, TN.

    Goal: To determine the mechanisms by which IgM restores immune homeostasis in new-onset diabetic NOD mice.Methods: 1) 5wks old non-obese diabetic (NOD) mice received mouse…
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