2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…2019 American Transplant Congress
Decline in Club Cell Secretory Protein Results in Immune Responses to Lung Self-Antigens (Kα1 Tubulin and Collagen V) and Development of Chronic Rejection Following Human Lung Transplantation
*Purpose: Club cell secretory protein (CCSP) levels have been employed as a biomarker for respiratory stress in athletes, asthma patients, and in experimental acute and…2019 American Transplant Congress
Treg Plasticity is Induced by ENV,HERV1_I and UPR Activation in De Novo Autoimmune Hepatitis
*Purpose: FOXP3+regulatory T cells (Tregs) are not a terminally differentiated population & can, under specific environmental conditions, acquire the phenotype of effector T cells. We…2019 American Transplant Congress
Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation
*Purpose: According to the latest Banff’s criteria approved in 2003, antibody mediated rejections following renal transplantation are divided into 2 types namely C4d + and…2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…2019 American Transplant Congress
Development of Non-Human Leukocyte Antigen Antibodies in Cardiac Antibody-Mediated Rejection
*Purpose: Antibody-mediated rejection (AMR), mainly driven by the development of donor-specific antibodies (DSA) directed against mismatched donor class I and class II HLA, is a…2019 American Transplant Congress
Ischemic Preconditioning Attenuates Renal Ischemia-Reperfusion Injury through Activating the Nrf2/HO-1 Pathway Enhanced Autophagy
*Purpose: Ischemic preconditioning (IPC), which is a brief and nonlethal episode of ischemia, confers protection against subsequent ischemia-reperfusion (I/R) through the up-regulation of endogenous protective…2019 American Transplant Congress
Use of Anti-Vimentin Antibodies as a Possible Marker for Graft Dysfunction Following Renal Transplant, a Prospective Study
*Purpose: In our previously published work, we showed that presence of anti-vimentin antibodies (AVA) after renal transplant correlated with early IFTA (Interstitial Fibrosis and Tubular…2018 American Transplant Congress
Prevention and Reversal of Diabetes through Restoration of B and T Cell Regulation and Immune Homeostasis
Goal: To determine the mechanisms by which IgM restores immune homeostasis in new-onset diabetic NOD mice.Methods: 1) 5wks old non-obese diabetic (NOD) mice received mouse…2018 American Transplant Congress
Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immune Regulatory Proteins in Lung Transplant Recipient with Primary Graft Dysfunction
Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.
Background: Circulating exosomes isolated from lung transplant recipients (LTxRs) with acute or chronic rejection contains lung self-antigens (SAgs), K alpha 1 tubulin (Kα1T) and collagen…
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