Articles tagged "Autoimmunity"

2020 American Transplant Congress
Exosomes Containing Kidney Self-Antigens (Collagen Iv, Fibronectin, Perlecan) Predicts Progression of Chronic Immune Injury in Kidney Transplant Recipients
R. Ravichandran¹, Y. Itabashi¹, R. Heilman², A. Jaramillo², D. Ramon², M. Buras², B. Kaplan³, T. Mohanakumar¹, S. Sukumaran Nair²
¹St. Joseph’s Hospital, Phoenix, AZ, ²Mayo Clinic, Phoenix, AZ, ³Baylor Scott and White, Georgetown, TX
*Purpose: We have shown that circulating exosome with lung self-antigens (SAgs) are detectable 1 year prior to chronic lung allograft dysfunction, independent of circulating antibodies.…
2020 American Transplant Congress
Antibodies to Vascular Autoantigens Are Associated with Poor Long-Term Survival of Liver Re-Transplant
Q. Xu¹, V. C. McAlister², S. Leckie², A. A. House², A. Zeevi¹
¹Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada
*Purpose: Autoantibodies, which may be generated in transplantation through the exposure of cryptic antigens, are reported to be detrimental for allograft survival. We have demonstrated…
2020 American Transplant Congress
Effect of Low vs Standard Dosage of Anti-Thymocyte Globulin Induction Therapy on the Co-Inducible Molecules (Cd28, CTLA-4, ICOS, PD-1) Expression Pattern in T Regulatory Cell
G. Queipo¹, A. Hernandez-Mendoza¹, M. Estrada-Matus², M. Fonseca-Sanchez¹, F. Oviedo¹, L. García-Cobarruvias³, J. Prieto Chávez⁴, L. Pizarro⁵, L. Morales-Buenrostro⁶
¹Human Genetics, Hospital General de Mexico-Eduardo Liceaga Facultad de Medicina UNAM, Mexico City, Mexico, ²Nephrology, Instituno Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Transplant Unit, Hospital General de Mexico-Eduardo Liceaga, Mexico City, Mexico, ⁴Flow Cytometry Core, Mexican Social Security Institute, Mexico City, Mexico, ⁵Unit on Immunochemistry, Medical Research, Specialties Hospital of the National Medical Centre “SigloXXI”, Mexico City, Mexico, ⁶Nephrology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico
*Purpose: Two thymoglobulin (TG) dosages effect on the Tregulatory cell (Treg) and describe the behavior of the co-stimulatory pathways in terms of FIM and gene…
2020 American Transplant Congress
Exosomes Released from Natural Killer Cells Activation of Immune Responses: Role in Chronic Lung Allograft Dysfunction
R. Ravichandran, Y. Itabashi, W. Liu, M. Rahman, S. Bansal, R. Bremner, M. Smith, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Recent studies demonstrated natural killer (NK) cells can induce cytotoxicity both by direct cytotoxic mechanisms and antibody (Ab) dependent cytotoxicity; however its role in…
2020 American Transplant Congress
Single versus Dual Immunosuppression in Liver Transplantation for Autoimmune Liver Diseases
S. Sterling¹, S. Hamel¹, C. Garza¹, I. Feurer², S. Rega², S. Alexopoulos³, M. Izzy⁴
¹Pharmacy, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt Transplant Center, Nashville, TN, ³Liver Transplant Surgery, Vanderbilt Transplant Center, Nashville, TN, ⁴Transplant Hepatology, Vanderbilt Transplant Center, Nashville, TN
*Purpose: There is limited evidence on the optimal maintenance immunosuppression after liver transplant (LT) for primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and autoimmune…
2020 American Transplant Congress
T-cell Receptor Deep Sequencing to Distinguish Autoimmune Recurrence from Allograft Rejection in Liver Transplant Patients with Autoimmune Liver Disease
K. J. Yang¹, M. Martinez², B. Shonts¹, C. A. Parks¹, A. Z. Obradovic¹, T. M. Savage¹, E. Spyrou¹, S. Lau¹, M. I. Colquhoun¹, K. Rodgers¹, E. Verna³, S. M. Coley⁴, S. Yang¹, Y. Shen⁵, M. Sykes¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Department of Medicine, Columbia University, New York, NY, ⁴Department of Pathology, Columbia University, New York, NY, ⁵Center for Computational Biology & Bioinformatics, Department of Systems Biology, Columbia University, New York, NY
*Purpose: Patients who undergo liver transplantation for autoimmune liver disease (ALD) experience high rates of graft failure. The relative roles of recurrent ALD and rejection…
2020 American Transplant Congress
Novel micro-RNA and Microbiome Signature Profiles as Biomarkers for Predicting the Risk of Autoimmune Type 1 Diabetes Development
P. Chhabra¹, G. Ricardo¹, A. Spano², V. Mas¹, M. Timko², K. Brayman¹
¹Dept of Surgery, University of Virginia Health System, Charlottesville, VA, ²Dept of Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To identify reliable microRNA (miRNA) and microbiome biomarkers for predicting risk of autoimmune beta-cell destruction in type 1 diabetes (T1D) and to investigate alterations…
2020 American Transplant Congress
Circulating Tissue Specific Exosomes Enable Noninvasive Diagnosis of Acute Cellular Rejection in Clinical Heart Transplantation
L. Korutla¹, R. Hu¹, C. Romano¹, M. Molina¹, C. Sciortino², C. Mullan³, R. McGargle², H. Kagawa², A. Kilic², A. Naji⁴, P. Vallabhajosyula³
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Surgery, Yale University, New Haven, CT, ⁴University of Pennsylvania, Philadelphia, PA
*Purpose: There is a critical need for development of noninvasive biomarkers for allograft surveillance and diagnosis of rejection in heart transplant patients, as endomyocardial biopsy…
2020 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens, Myosin and Vimentin, Induced Immune Responses Leading to Rejection Following Heterotopic Cardiac Transplantation Immunosuppressed with mTOR Inhibitor and Low Dose of IL-2 Therapy
Y. Itabashi, R. Ravichandran, S. Bansal, T. Fleming, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the role for circulating exosomes with cardiac self-antigens (SAgs) (Myosin, Vimentin) in the development of immune…
2020 American Transplant Congress
Pre-Transplant Detection of Anti-at1r Antibodies and Pediatric Kidney Transplantation Outcomes
K. Hitchman¹, C. Usenko², R. Hinojosa¹, D. Ranch¹
¹UT Health San Antonio, San Antonio, TX, ²University Health System, San Antonio, TX
*Purpose: Describe correlations between pre-transplant (PreTXP) presence of anti-angiotensin II receptor type 1 antibodies (AT1R Ab) and post-transplant (PostTXP) outcomes in a pediatric kidney transplant…