Articles tagged "Autoimmunity"

2022 American Transplant Congress
Protein and Transcriptomic Differences Between High and Low Neointimal Arteries in Human Cardiac Allograft Vasculopathy Rejected Grafts
J. Nevarez-Mejia¹, H. C. Pickering¹, R. A. Sosa¹, R. P. Lau¹, G. A. Fishbein¹, W. M. Baldwin III², R. L. Fairchild², E. F. Reed¹
¹University of California, Los Angeles, Los Angeles, CA, ²Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of graft failure and mortality following heart transplantation. Donor specific antibodies (DSA) contribute to CAV progression…
2022 American Transplant Congress
Perturbations in Podocyte Transcriptome and Biological Pathways Induced by Injury Caused by FSGS Associated Circulating Factors
P. Rashmi¹, T. Sigdel¹, D. Rychkov¹, I. Damm¹, F. Vincenti¹, C. Craik¹, J. Reiser², M. Sarwal¹
¹UCSF, San Francisco, CA, ²Rush University, Chicago, IL
*Purpose: Focal segmental glomerulosclerosis (FSGS) remains a disease without specific therapy for primary disease and a high rate of recurrence after renal transplant. Circulating factors…
2022 American Transplant Congress
Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Cells
A. R. Gupta¹, J. Wang², C. Lareau³, I. Sun², J. Bautista¹, J. Gardner¹
¹Department of Surgery, University of California San Francisco, San Francisco, CA, ²Diabetes Center, University of California San Francisco, San Francisco, CA, ³Department of Pathology, Stanford University, Stanford, CA
*Purpose: The Autoimmune Regulator (Aire) gene, essential for central tolerance through its regulation of tissue-specific antigens in medullary thymic epithelial cells, is also expressed in…
2022 American Transplant Congress
Local Intragraft Humoral Immune Response in Chronic Lung Allograft Dysfunction
E. Miyamoto¹, S. C. Juvet², D. Vosoughi², J. Wang², J. Al-Refaee², T. Daigneault², A. Duong², S. Moshkelgosha², S. Keshavjee², K. Tinckam², A. Chruscinski³, D. Hwang⁴, T. Martinu²
¹Tenri Hospital Japan, University Health Network Canada, Nara, Japan, ²University Health Network, Toronto, ON, Canada, ³Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ⁴Sunnybrook Health Science Centre, Toronto, ON, Canada
*Purpose: Donor HLA-specific antibody (DSA) and antibody against self-antigens (self-antigen antibody) can cause injury and lead to chronic lung allograft dysfunction (CLAD) after lung transplantation…
2022 American Transplant Congress
Allogenic Cardiac Progenitor Cells Transplantation with Immune Suppressant Cyclosporine a Recovers Myocardial Infarction in Rodent Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal
Pediatrics, Lurie Childrens Hospital, Chicago, IL
*Purpose: Cardiac progenitor cells (CPCs) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo immune…
2022 American Transplant Congress
Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion
I. Kaci¹, S. Lan¹, H. Kim¹, A. Karakeussian Rimbaud¹, F. Migneault¹, J. Turgeon¹, N. Patey², M. Dieudé¹, M. Hébert¹
¹Research Centre, Centre hospitalier de l’Université de Montréal, Montreal, QC, Canada, ²Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…
2022 American Transplant Congress
Cd137 on Host Dendritic Cells Fine-Tunes the Intesity of Donor T Cells in Systemic Alloinmmune Responses
S. Park¹, H. Cho², B. Kwon³, J. Lee⁴, H. Park¹, J. Park⁴, K. Park⁴, K. Yoo⁴
¹Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ²University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ³School of Biological Sciences, University of Ulsan, Ulsan, Korea, Republic of, ⁴Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea, Republic of
*Purpose: CD137 is a potent costimulatory receptor for CD8+ T cells but it also regulates dendritic cells (DCs) to suppress immune responses. In this study,…
2022 American Transplant Congress
Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression
J. Mattke¹, M. Plunk¹, R. R. Kane¹, B. Naziruddin²
¹Baylor University, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX
*Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
2022 American Transplant Congress
Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation
S. Vasu¹, C. Darden², J. Mattke², Y. Liu³, M. C. Lawrence³, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX, ³Baylor University Medical Center, Dallas, TX
*Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…
2022 American Transplant Congress
The Pre-Transplant Non-HLA Antibody Burden Predicts the Development of Histology of Antibody-Mediated Rejection After Kidney Transplantation
A. Senev¹, B. Ray², J. Hariharan², C. Heylen², M. Emonds¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Immucor Inc.,, Norcross, GA
*Purpose: Many kidney allografts fail due to the occurrence of antibody-mediated rejection (ABMR), related to donor-specific anti-HLA antibodies (HLA-DSA). However, the histology of ABMR can…

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