ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Autoimmunity"

  • 2020 American Transplant Congress

    CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus

    H. Cho1, J. Lee2, B. Kwon3, S. Park1, H. Park1, K. Yoo2, K. Park2, J. Kim3

    1Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of, 2Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, 3Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of

    *Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…
  • 2020 American Transplant Congress

    Angiotensin II Type 1 Receptor Antibodies are Associated with Younger Age and Renal Dysfunction in Pediatric Kidney Transplantation

    M. Pearl1, E. T. Chambers2, A. Kirk2, R. Garro3, B. L. Warshaw3, P. Grimm4, R. Ettenger1, E. Reed1

    1UCLA, Los Angeles, CA, 2Duke, Durham, NC, 3Emory, Atlanta, GA, 4Stanford, Stanford, CA

    *Purpose: The significance of non-HLA antibodies in renal transplantation remains unclear. In small single center retrospective studies, angiotensin II type 1 receptor antibody (AT1R-Ab) has…
  • 2020 American Transplant Congress

    Exosomes Containing Kidney Self-Antigens (Collagen Iv, Fibronectin, Perlecan) Predicts Progression of Chronic Immune Injury in Kidney Transplant Recipients

    R. Ravichandran1, Y. Itabashi1, R. Heilman2, A. Jaramillo2, D. Ramon2, M. Buras2, B. Kaplan3, T. Mohanakumar1, S. Sukumaran Nair2

    1St. Joseph’s Hospital, Phoenix, AZ, 2Mayo Clinic, Phoenix, AZ, 3Baylor Scott and White, Georgetown, TX

    *Purpose: We have shown that circulating exosome with lung self-antigens (SAgs) are detectable 1 year prior to chronic lung allograft dysfunction, independent of circulating antibodies.…
  • 2020 American Transplant Congress

    Antibodies to Vascular Autoantigens Are Associated with Poor Long-Term Survival of Liver Re-Transplant

    Q. Xu1, V. C. McAlister2, S. Leckie2, A. A. House2, A. Zeevi1

    1Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada

    *Purpose: Autoantibodies, which may be generated in transplantation through the exposure of cryptic antigens, are reported to be detrimental for allograft survival. We have demonstrated…
  • 2020 American Transplant Congress

    Effect of Low vs Standard Dosage of Anti-Thymocyte Globulin Induction Therapy on the Co-Inducible Molecules (Cd28, CTLA-4, ICOS, PD-1) Expression Pattern in T Regulatory Cell

    G. Queipo1, A. Hernandez-Mendoza1, M. Estrada-Matus2, M. Fonseca-Sanchez1, F. Oviedo1, L. García-Cobarruvias3, J. Prieto Chávez4, L. Pizarro5, L. Morales-Buenrostro6

    1Human Genetics, Hospital General de Mexico-Eduardo Liceaga Facultad de Medicina UNAM, Mexico City, Mexico, 2Nephrology, Instituno Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Transplant Unit, Hospital General de Mexico-Eduardo Liceaga, Mexico City, Mexico, 4Flow Cytometry Core, Mexican Social Security Institute, Mexico City, Mexico, 5Unit on Immunochemistry, Medical Research, Specialties Hospital of the National Medical Centre “SigloXXI”, Mexico City, Mexico, 6Nephrology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    *Purpose: Two thymoglobulin (TG) dosages effect on the Tregulatory cell (Treg) and describe the behavior of the co-stimulatory pathways in terms of FIM and gene…
  • 2020 American Transplant Congress

    Exosomes Released from Natural Killer Cells Activation of Immune Responses: Role in Chronic Lung Allograft Dysfunction

    R. Ravichandran, Y. Itabashi, W. Liu, M. Rahman, S. Bansal, R. Bremner, M. Smith, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Recent studies demonstrated natural killer (NK) cells can induce cytotoxicity both by direct cytotoxic mechanisms and antibody (Ab) dependent cytotoxicity; however its role in…
  • 2019 American Transplant Congress

    Decline in Club Cell Secretory Protein Results in Immune Responses to Lung Self-Antigens (Kα1 Tubulin and Collagen V) and Development of Chronic Rejection Following Human Lung Transplantation

    Y. Itabashi1, R. Ravichandran1, M. Sharma1, R. Hachem2, R. Bremner1, M. Smith1, T. Mohanakumar1

    1Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, 2Washington University School of Medicine, St. Louis, MO

    *Purpose: Club cell secretory protein (CCSP) levels have been employed as a biomarker for respiratory stress in athletes, asthma patients, and in experimental acute and…
  • 2019 American Transplant Congress

    Treg Plasticity is Induced by ENV,HERV1_I and UPR Activation in De Novo Autoimmune Hepatitis

    J. Yao1, A. Ling1, A. Arterbery1, Y. Avitzur2, S. Lobritto3, M. Martinez3, U. Ekong1

    1Yale University, New Haven, CT, 2University of Toronto, Toronto, ON, Canada, 3Columbia University, New York, NY

    *Purpose: FOXP3+regulatory T cells (Tregs) are not a terminally differentiated population & can, under specific environmental conditions, acquire the phenotype of effector T cells. We…
  • 2019 American Transplant Congress

    Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation

    S. Kanangat1, I. Kurbegovic-Skaljic2, D. Cimbaluk2, M. Oppermann2, S. Jensik3, E. Hollinger3, O. Olaitan4, R. DeCresce2

    1Tumor Immunology, NIH/NCI Bethesda MD,USA, Bethesda, MD, 2Pathology, Rush University Medical Center, Chicago, IL, 3Surgery, Rush University Medical Center, Chicago, IL, 4Tumor Immunology, Rush University Medical Center, Chicago, IL

    *Purpose: According to the latest Banff’s criteria approved in 2003, antibody mediated rejections following renal transplantation are divided into 2 types namely C4d + and…
  • 2019 American Transplant Congress

    JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively

    H. Xu1, A. Merchak1, J. Xu2, Y. Huang1, S. T. Ildstad1

    1University of Louisville, Institute for Cellular Therapeutics, Louisville, KY, 2DuPont Manual High School, Louisville, KY

    *Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…
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