Articles tagged "Autoimmunity"

2020 American Transplant Congress
Novel micro-RNA and Microbiome Signature Profiles as Biomarkers for Predicting the Risk of Autoimmune Type 1 Diabetes Development
P. Chhabra¹, G. Ricardo¹, A. Spano², V. Mas¹, M. Timko², K. Brayman¹
¹Dept of Surgery, University of Virginia Health System, Charlottesville, VA, ²Dept of Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To identify reliable microRNA (miRNA) and microbiome biomarkers for predicting risk of autoimmune beta-cell destruction in type 1 diabetes (T1D) and to investigate alterations…
2020 American Transplant Congress
Circulating Tissue Specific Exosomes Enable Noninvasive Diagnosis of Acute Cellular Rejection in Clinical Heart Transplantation
L. Korutla¹, R. Hu¹, C. Romano¹, M. Molina¹, C. Sciortino², C. Mullan³, R. McGargle², H. Kagawa², A. Kilic², A. Naji⁴, P. Vallabhajosyula³
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Surgery, Yale University, New Haven, CT, ⁴University of Pennsylvania, Philadelphia, PA
*Purpose: There is a critical need for development of noninvasive biomarkers for allograft surveillance and diagnosis of rejection in heart transplant patients, as endomyocardial biopsy…
2020 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens, Myosin and Vimentin, Induced Immune Responses Leading to Rejection Following Heterotopic Cardiac Transplantation Immunosuppressed with mTOR Inhibitor and Low Dose of IL-2 Therapy
Y. Itabashi, R. Ravichandran, S. Bansal, T. Fleming, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the role for circulating exosomes with cardiac self-antigens (SAgs) (Myosin, Vimentin) in the development of immune…
2020 American Transplant Congress
Pre-Transplant Detection of Anti-at1r Antibodies and Pediatric Kidney Transplantation Outcomes
K. Hitchman¹, C. Usenko², R. Hinojosa¹, D. Ranch¹
¹UT Health San Antonio, San Antonio, TX, ²University Health System, San Antonio, TX
*Purpose: Describe correlations between pre-transplant (PreTXP) presence of anti-angiotensin II receptor type 1 antibodies (AT1R Ab) and post-transplant (PostTXP) outcomes in a pediatric kidney transplant…
2020 American Transplant Congress
Morbidity in Lung Transplant for Connective Tissue Disease
S. Minkove¹, E. Bush², P. Shah¹
¹Pulmonary and Critical Care, Johns Hopkins, Baltimore, MD, ²Thoracic Surgery, Johns Hopkins, Baltimore, MD
*Purpose: To evaluate the post-lung transplant comorbidities of patients with connective tissue disease (CTD) compared with an age-matched cohort of patients transplanted for idiopathic pulmonary…
2020 American Transplant Congress
Rare Genetic Mutation Triggering Acute Liver Failure in a Toddler Needing a Liver Transplant
C. B. Chen¹, N. Mistry Ambani¹, A. Zeft¹, R. Garcia-Naviero², V. Hupertz¹, K. Hashimoto¹, K. Radhakrishnan¹
¹Cleveland Clinic, Cleveland, OH, ²Akron Children's Hospital, Akron, OH
*Purpose: The AIRE gene plays an important role in immune tolerance by driving negative selection of self-recognizing T-cells. Mutations in this gene are responsible for…
2020 American Transplant Congress
Immune Response Following Cardiac Progenitor Cells Transplantation in Rat Myocardial Infarction Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Wang, M. Yasir Arfat, X. Fu, S. Kaushal
Surgery, University of Maryland, Baltimore, MD
*Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo…
2020 American Transplant Congress
Natural Antibodies and Left Ventricular Assist Device Complications
S. B. See¹, D. Onat², E. Hittesdorf³, F. McDougan⁴, M. Yuzefpolskaya², V. K. Topkara², Y. Naka⁵, H. Takayama⁵, K. Takeda⁵, G. Milligan⁶, D. Wencker⁶, S. Hall⁶, M. Askar⁶, P. Kimball⁴, G. Wagener³, P. C. Colombo², E. Zorn¹
¹Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, ²Department of Medicine, Columbia University Irving Medical Center, New York, NY, ³Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, ⁴Department of Transplant Surgery, Virginia Commonwealth University, Richmond, VA, ⁵Department of Surgery, Columbia University Irving Medical Center, New York, NY, ⁶Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, TX
*Purpose: Left ventricular assist device (LVAD) implantation is followed by a sharp increase in serum levels of IgG natural antibodies (Nabs) recognizing oxidation-specific epitopes (OSE)…
2020 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…
2020 American Transplant Congress
Profiling Non-HLA Antibodies in Antibody-Mediated Rejection Following Cardiac Transplantation
S. B. See¹, B. S. Mantell², K. J. Clerkin³, B. Ray⁴, E. R. Vasilescu⁵, C. Marboe⁵, Y. Naka⁶, S. Restaino³, P. C. Colombo³, L. Addonizio², M. A. Farr³, E. Zorn¹
¹Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, ²Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, ³Department of Medicine, Columbia University Irving Medical Center, New York, NY, ⁴Research and Development, Immucor, Waukesha, WI, ⁵Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, ⁶Department of Surgery, Columbia University Irving Medical Center, New York, NY
*Purpose: Antibody-mediated rejection (AMR) driven by the development of donor-specific antibodies (DSA) directed against mismatched donor HLA is a major risk factor for graft loss…