ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Autoimmunity"

  • 2020 American Transplant Congress

    Morbidity in Lung Transplant for Connective Tissue Disease

    S. Minkove1, E. Bush2, P. Shah1

    1Pulmonary and Critical Care, Johns Hopkins, Baltimore, MD, 2Thoracic Surgery, Johns Hopkins, Baltimore, MD

    *Purpose: To evaluate the post-lung transplant comorbidities of patients with connective tissue disease (CTD) compared with an age-matched cohort of patients transplanted for idiopathic pulmonary…
  • 2020 American Transplant Congress

    Rare Genetic Mutation Triggering Acute Liver Failure in a Toddler Needing a Liver Transplant

    C. B. Chen1, N. Mistry Ambani1, A. Zeft1, R. Garcia-Naviero2, V. Hupertz1, K. Hashimoto1, K. Radhakrishnan1

    1Cleveland Clinic, Cleveland, OH, 2Akron Children's Hospital, Akron, OH

    *Purpose: The AIRE gene plays an important role in immune tolerance by driving negative selection of self-recognizing T-cells. Mutations in this gene are responsible for…
  • 2020 American Transplant Congress

    Immune Response Following Cardiac Progenitor Cells Transplantation in Rat Myocardial Infarction Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Wang, M. Yasir Arfat, X. Fu, S. Kaushal

    Surgery, University of Maryland, Baltimore, MD

    *Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo…
  • 2020 American Transplant Congress

    Natural Antibodies and Left Ventricular Assist Device Complications

    S. B. See1, D. Onat2, E. Hittesdorf3, F. McDougan4, M. Yuzefpolskaya2, V. K. Topkara2, Y. Naka5, H. Takayama5, K. Takeda5, G. Milligan6, D. Wencker6, S. Hall6, M. Askar6, P. Kimball4, G. Wagener3, P. C. Colombo2, E. Zorn1

    1Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 2Department of Medicine, Columbia University Irving Medical Center, New York, NY, 3Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, 4Department of Transplant Surgery, Virginia Commonwealth University, Richmond, VA, 5Department of Surgery, Columbia University Irving Medical Center, New York, NY, 6Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, TX

    *Purpose: Left ventricular assist device (LVAD) implantation is followed by a sharp increase in serum levels of IgG natural antibodies (Nabs) recognizing oxidation-specific epitopes (OSE)…
  • 2020 American Transplant Congress

    Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury

    V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…
  • 2020 American Transplant Congress

    Profiling Non-HLA Antibodies in Antibody-Mediated Rejection Following Cardiac Transplantation

    S. B. See1, B. S. Mantell2, K. J. Clerkin3, B. Ray4, E. R. Vasilescu5, C. Marboe5, Y. Naka6, S. Restaino3, P. C. Colombo3, L. Addonizio2, M. A. Farr3, E. Zorn1

    1Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 2Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, 3Department of Medicine, Columbia University Irving Medical Center, New York, NY, 4Research and Development, Immucor, Waukesha, WI, 5Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 6Department of Surgery, Columbia University Irving Medical Center, New York, NY

    *Purpose: Antibody-mediated rejection (AMR) driven by the development of donor-specific antibodies (DSA) directed against mismatched donor HLA is a major risk factor for graft loss…
  • 2020 American Transplant Congress

    CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus

    H. Cho1, J. Lee2, B. Kwon3, S. Park1, H. Park1, K. Yoo2, K. Park2, J. Kim3

    1Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of, 2Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, 3Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of

    *Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…
  • 2020 American Transplant Congress

    Angiotensin II Type 1 Receptor Antibodies are Associated with Younger Age and Renal Dysfunction in Pediatric Kidney Transplantation

    M. Pearl1, E. T. Chambers2, A. Kirk2, R. Garro3, B. L. Warshaw3, P. Grimm4, R. Ettenger1, E. Reed1

    1UCLA, Los Angeles, CA, 2Duke, Durham, NC, 3Emory, Atlanta, GA, 4Stanford, Stanford, CA

    *Purpose: The significance of non-HLA antibodies in renal transplantation remains unclear. In small single center retrospective studies, angiotensin II type 1 receptor antibody (AT1R-Ab) has…
  • 2020 American Transplant Congress

    Exosomes Containing Kidney Self-Antigens (Collagen Iv, Fibronectin, Perlecan) Predicts Progression of Chronic Immune Injury in Kidney Transplant Recipients

    R. Ravichandran1, Y. Itabashi1, R. Heilman2, A. Jaramillo2, D. Ramon2, M. Buras2, B. Kaplan3, T. Mohanakumar1, S. Sukumaran Nair2

    1St. Joseph’s Hospital, Phoenix, AZ, 2Mayo Clinic, Phoenix, AZ, 3Baylor Scott and White, Georgetown, TX

    *Purpose: We have shown that circulating exosome with lung self-antigens (SAgs) are detectable 1 year prior to chronic lung allograft dysfunction, independent of circulating antibodies.…
  • 2020 American Transplant Congress

    Antibodies to Vascular Autoantigens Are Associated with Poor Long-Term Survival of Liver Re-Transplant

    Q. Xu1, V. C. McAlister2, S. Leckie2, A. A. House2, A. Zeevi1

    1Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada

    *Purpose: Autoantibodies, which may be generated in transplantation through the exposure of cryptic antigens, are reported to be detrimental for allograft survival. We have demonstrated…
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