ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Autoimmunity"

  • 2020 American Transplant Congress

    Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury

    V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…
  • 2020 American Transplant Congress

    Profiling Non-HLA Antibodies in Antibody-Mediated Rejection Following Cardiac Transplantation

    S. B. See1, B. S. Mantell2, K. J. Clerkin3, B. Ray4, E. R. Vasilescu5, C. Marboe5, Y. Naka6, S. Restaino3, P. C. Colombo3, L. Addonizio2, M. A. Farr3, E. Zorn1

    1Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 2Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, 3Department of Medicine, Columbia University Irving Medical Center, New York, NY, 4Research and Development, Immucor, Waukesha, WI, 5Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 6Department of Surgery, Columbia University Irving Medical Center, New York, NY

    *Purpose: Antibody-mediated rejection (AMR) driven by the development of donor-specific antibodies (DSA) directed against mismatched donor HLA is a major risk factor for graft loss…
  • 2020 American Transplant Congress

    CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus

    H. Cho1, J. Lee2, B. Kwon3, S. Park1, H. Park1, K. Yoo2, K. Park2, J. Kim3

    1Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of, 2Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, 3Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of

    *Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…
  • 2020 American Transplant Congress

    Angiotensin II Type 1 Receptor Antibodies are Associated with Younger Age and Renal Dysfunction in Pediatric Kidney Transplantation

    M. Pearl1, E. T. Chambers2, A. Kirk2, R. Garro3, B. L. Warshaw3, P. Grimm4, R. Ettenger1, E. Reed1

    1UCLA, Los Angeles, CA, 2Duke, Durham, NC, 3Emory, Atlanta, GA, 4Stanford, Stanford, CA

    *Purpose: The significance of non-HLA antibodies in renal transplantation remains unclear. In small single center retrospective studies, angiotensin II type 1 receptor antibody (AT1R-Ab) has…
  • 2020 American Transplant Congress

    Exosomes Containing Kidney Self-Antigens (Collagen Iv, Fibronectin, Perlecan) Predicts Progression of Chronic Immune Injury in Kidney Transplant Recipients

    R. Ravichandran1, Y. Itabashi1, R. Heilman2, A. Jaramillo2, D. Ramon2, M. Buras2, B. Kaplan3, T. Mohanakumar1, S. Sukumaran Nair2

    1St. Joseph’s Hospital, Phoenix, AZ, 2Mayo Clinic, Phoenix, AZ, 3Baylor Scott and White, Georgetown, TX

    *Purpose: We have shown that circulating exosome with lung self-antigens (SAgs) are detectable 1 year prior to chronic lung allograft dysfunction, independent of circulating antibodies.…
  • 2020 American Transplant Congress

    Antibodies to Vascular Autoantigens Are Associated with Poor Long-Term Survival of Liver Re-Transplant

    Q. Xu1, V. C. McAlister2, S. Leckie2, A. A. House2, A. Zeevi1

    1Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada

    *Purpose: Autoantibodies, which may be generated in transplantation through the exposure of cryptic antigens, are reported to be detrimental for allograft survival. We have demonstrated…
  • 2020 American Transplant Congress

    Effect of Low vs Standard Dosage of Anti-Thymocyte Globulin Induction Therapy on the Co-Inducible Molecules (Cd28, CTLA-4, ICOS, PD-1) Expression Pattern in T Regulatory Cell

    G. Queipo1, A. Hernandez-Mendoza1, M. Estrada-Matus2, M. Fonseca-Sanchez1, F. Oviedo1, L. García-Cobarruvias3, J. Prieto Chávez4, L. Pizarro5, L. Morales-Buenrostro6

    1Human Genetics, Hospital General de Mexico-Eduardo Liceaga Facultad de Medicina UNAM, Mexico City, Mexico, 2Nephrology, Instituno Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 3Transplant Unit, Hospital General de Mexico-Eduardo Liceaga, Mexico City, Mexico, 4Flow Cytometry Core, Mexican Social Security Institute, Mexico City, Mexico, 5Unit on Immunochemistry, Medical Research, Specialties Hospital of the National Medical Centre “SigloXXI”, Mexico City, Mexico, 6Nephrology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    *Purpose: Two thymoglobulin (TG) dosages effect on the Tregulatory cell (Treg) and describe the behavior of the co-stimulatory pathways in terms of FIM and gene…
  • 2020 American Transplant Congress

    Exosomes Released from Natural Killer Cells Activation of Immune Responses: Role in Chronic Lung Allograft Dysfunction

    R. Ravichandran, Y. Itabashi, W. Liu, M. Rahman, S. Bansal, R. Bremner, M. Smith, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Recent studies demonstrated natural killer (NK) cells can induce cytotoxicity both by direct cytotoxic mechanisms and antibody (Ab) dependent cytotoxicity; however its role in…
  • 2020 American Transplant Congress

    Single versus Dual Immunosuppression in Liver Transplantation for Autoimmune Liver Diseases

    S. Sterling1, S. Hamel1, C. Garza1, I. Feurer2, S. Rega2, S. Alexopoulos3, M. Izzy4

    1Pharmacy, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt Transplant Center, Nashville, TN, 3Liver Transplant Surgery, Vanderbilt Transplant Center, Nashville, TN, 4Transplant Hepatology, Vanderbilt Transplant Center, Nashville, TN

    *Purpose: There is limited evidence on the optimal maintenance immunosuppression after liver transplant (LT) for primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and autoimmune…
  • 2020 American Transplant Congress

    T-cell Receptor Deep Sequencing to Distinguish Autoimmune Recurrence from Allograft Rejection in Liver Transplant Patients with Autoimmune Liver Disease

    K. J. Yang1, M. Martinez2, B. Shonts1, C. A. Parks1, A. Z. Obradovic1, T. M. Savage1, E. Spyrou1, S. Lau1, M. I. Colquhoun1, K. Rodgers1, E. Verna3, S. M. Coley4, S. Yang1, Y. Shen5, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Department of Medicine, Columbia University, New York, NY, 4Department of Pathology, Columbia University, New York, NY, 5Center for Computational Biology & Bioinformatics, Department of Systems Biology, Columbia University, New York, NY

    *Purpose: Patients who undergo liver transplantation for autoimmune liver disease (ALD) experience high rates of graft failure. The relative roles of recurrent ALD and rejection…
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