Articles tagged "Autoimmunity"

2022 American Transplant Congress
Temporal Changes in the Peripheral Immune Profile of Acute Rejection Highlight New Mechanisms of Alloimmunity and Potential Non-Invasive Biomarkers of Rejection in Pediatric Liver Transplantation
D. N. Sarode¹, B. Rocque¹, A. Barbetta¹, P. Singh¹, C. Goldbeck¹, C. Weaver², O. Akbari¹, R. Kohli², J. Emamaullee¹
¹University of Southern California Keck School of Medicine, Los Angeles, CA, ²Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: Acute rejection (AR) is common in pediatric liver transplantation (LT) and can impact late graft loss. Immune subpopulations mediating AR in LT have not…
2022 American Transplant Congress
Galectin-3 Expression in Autoimmune Hepatitis
N. Limon-de la Rosa¹, C. Moreno-Ramírez², E. Cervantes-Alvarez³, D. Yoeli⁴, I. Vasic⁴, M. Kriss⁵, C. A. Huang⁴, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Universidad de Guadalajara , Centro Universitario de la Costa., Puerto Vallarta Jalisco, Mexico, ³Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁴University of Colorado Anschutz Medical Campus, Denver, CO, ⁵University of Colorado Anschutz Medical Campus, Aurora, CO
*Purpose: Autoimmune hepatitis (AIH) is characterized by chronic inflammation in which healthy liver cells are targeted by one’s immune system. The persistent inflammatory milieu can…
2022 American Transplant Congress
Protein and Transcriptomic Differences Between High and Low Neointimal Arteries in Human Cardiac Allograft Vasculopathy Rejected Grafts
J. Nevarez-Mejia¹, H. C. Pickering¹, R. A. Sosa¹, R. P. Lau¹, G. A. Fishbein¹, W. M. Baldwin III², R. L. Fairchild², E. F. Reed¹
¹University of California, Los Angeles, Los Angeles, CA, ²Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of graft failure and mortality following heart transplantation. Donor specific antibodies (DSA) contribute to CAV progression…
2021 American Transplant Congress
Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy
R. G. Gill¹, M. Coulombe², K. S. Beard¹, A. L. Burrack³
¹University of Colorado, Aurora, CO, ²Surgery, University of Colorado, Aurora, CO, ³Mircrobiology and Immunology, University of Minnesota, Minneapolis, MN
*Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…
2021 American Transplant Congress
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of At-1501
S. Perrin¹, A. Gill², C. Gill², P. Gustafson¹
¹Novus Therapeutics, Irvine, CA, ²ALS Therapy Development Institute, Cambridge, MA
*Purpose: Execute a phase 1 study of AT-1501 to assess safety, pharmacokinetics, and functional activity.*Methods: The study employed a placebo-controlled, sequential, dose-escalation design. 28 healthy…
2021 American Transplant Congress
Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-mediated Rejection
S. Clotet-Freixas¹, M. Kotlyar², C. M. McEvoy¹, C. Pastrello², S. Rodríguez-Ramírez¹, S. Farkona¹, H. Cardinal³, M. Dieudé³, M. Hébert³, Y. Li¹, O. Famure¹, P. Chen¹, S. Kim¹, E. Chan⁴, I. Jurisica², R. John¹, A. Chruscinski¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, ⁴Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR) causes >50% of late kidney graft losses. Although donor-specific antibodies (DSA) against HLA cause AMR, antibodies against non-HLA antigens are also…
2021 American Transplant Congress
Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes
D. A. Alagpulinsa, A. Jajoo, M. H. Chapin II, M. C. Poznansky
Vaccine & Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…
2021 American Transplant Congress
Recurrence and Outcome of Anti-GBM Glomerulonephritis After Kidney Transplantation: A Belgian Multicenter Study
S. Coche
Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
*Purpose: Recurrence of anti-glomerular basement membrane (anti-GBM) glomerulonephritis (GN) in the kidney graft is a rare event, described in limited case reports and registry analysis.…
2020 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies are Associated with Younger Age and Renal Dysfunction in Pediatric Kidney Transplantation
M. Pearl¹, E. T. Chambers², A. Kirk², R. Garro³, B. L. Warshaw³, P. Grimm⁴, R. Ettenger¹, E. Reed¹
¹UCLA, Los Angeles, CA, ²Duke, Durham, NC, ³Emory, Atlanta, GA, ⁴Stanford, Stanford, CA
*Purpose: The significance of non-HLA antibodies in renal transplantation remains unclear. In small single center retrospective studies, angiotensin II type 1 receptor antibody (AT1R-Ab) has…
2020 American Transplant Congress
Exosomes Containing Kidney Self-Antigens (Collagen Iv, Fibronectin, Perlecan) Predicts Progression of Chronic Immune Injury in Kidney Transplant Recipients
R. Ravichandran¹, Y. Itabashi¹, R. Heilman², A. Jaramillo², D. Ramon², M. Buras², B. Kaplan³, T. Mohanakumar¹, S. Sukumaran Nair²
¹St. Joseph’s Hospital, Phoenix, AZ, ²Mayo Clinic, Phoenix, AZ, ³Baylor Scott and White, Georgetown, TX
*Purpose: We have shown that circulating exosome with lung self-antigens (SAgs) are detectable 1 year prior to chronic lung allograft dysfunction, independent of circulating antibodies.…