ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Autoimmunity"

  • 2022 American Transplant Congress

    Allogenic Cardiac Progenitor Cells Transplantation with Immune Suppressant Cyclosporine a Recovers Myocardial Infarction in Rodent Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal

    Pediatrics, Lurie Childrens Hospital, Chicago, IL

    *Purpose: Cardiac progenitor cells (CPCs) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo immune…
  • 2022 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion

    I. Kaci1, S. Lan1, H. Kim1, A. Karakeussian Rimbaud1, F. Migneault1, J. Turgeon1, N. Patey2, M. Dieudé1, M. Hébert1

    1Research Centre, Centre hospitalier de l’Université de Montréal, Montreal, QC, Canada, 2Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…
  • 2022 American Transplant Congress

    Cd137 on Host Dendritic Cells Fine-Tunes the Intesity of Donor T Cells in Systemic Alloinmmune Responses

    S. Park1, H. Cho2, B. Kwon3, J. Lee4, H. Park1, J. Park4, K. Park4, K. Yoo4

    1Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, 2University of Ulsan College of Medicine, Ulsan, Korea, Republic of, 3School of Biological Sciences, University of Ulsan, Ulsan, Korea, Republic of, 4Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea, Republic of

    *Purpose: CD137 is a potent costimulatory receptor for CD8+ T cells but it also regulates dendritic cells (DCs) to suppress immune responses. In this study,…
  • 2021 American Transplant Congress

    Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy

    R. G. Gill1, M. Coulombe2, K. S. Beard1, A. L. Burrack3

    1University of Colorado, Aurora, CO, 2Surgery, University of Colorado, Aurora, CO, 3Mircrobiology and Immunology, University of Minnesota, Minneapolis, MN

    *Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…
  • 2021 American Transplant Congress

    A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of At-1501

    S. Perrin1, A. Gill2, C. Gill2, P. Gustafson1

    1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA

    *Purpose: Execute a phase 1 study of AT-1501 to assess safety, pharmacokinetics, and functional activity.*Methods: The study employed a placebo-controlled, sequential, dose-escalation design. 28 healthy…
  • 2021 American Transplant Congress

    Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-mediated Rejection

    S. Clotet-Freixas1, M. Kotlyar2, C. M. McEvoy1, C. Pastrello2, S. Rodríguez-Ramírez1, S. Farkona1, H. Cardinal3, M. Dieudé3, M. Hébert3, Y. Li1, O. Famure1, P. Chen1, S. Kim1, E. Chan4, I. Jurisica2, R. John1, A. Chruscinski1, A. Konvalinka1

    1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR) causes >50% of late kidney graft losses. Although donor-specific antibodies (DSA) against HLA cause AMR, antibodies against non-HLA antigens are also…
  • 2021 American Transplant Congress

    Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes

    D. A. Alagpulinsa, A. Jajoo, M. H. Chapin II, M. C. Poznansky

    Vaccine & Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…
  • 2021 American Transplant Congress

    Recurrence and Outcome of Anti-GBM Glomerulonephritis After Kidney Transplantation: A Belgian Multicenter Study

    S. Coche

    Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium

    *Purpose: Recurrence of anti-glomerular basement membrane (anti-GBM) glomerulonephritis (GN) in the kidney graft is a rare event, described in limited case reports and registry analysis.…
  • 2020 American Transplant Congress

    Morbidity in Lung Transplant for Connective Tissue Disease

    S. Minkove1, E. Bush2, P. Shah1

    1Pulmonary and Critical Care, Johns Hopkins, Baltimore, MD, 2Thoracic Surgery, Johns Hopkins, Baltimore, MD

    *Purpose: To evaluate the post-lung transplant comorbidities of patients with connective tissue disease (CTD) compared with an age-matched cohort of patients transplanted for idiopathic pulmonary…
  • 2020 American Transplant Congress

    Rare Genetic Mutation Triggering Acute Liver Failure in a Toddler Needing a Liver Transplant

    C. B. Chen1, N. Mistry Ambani1, A. Zeft1, R. Garcia-Naviero2, V. Hupertz1, K. Hashimoto1, K. Radhakrishnan1

    1Cleveland Clinic, Cleveland, OH, 2Akron Children's Hospital, Akron, OH

    *Purpose: The AIRE gene plays an important role in immune tolerance by driving negative selection of self-recognizing T-cells. Mutations in this gene are responsible for…
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