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Articles tagged "Autoimmunity"

  • 2022 American Transplant Congress

    Perturbations in Podocyte Transcriptome and Biological Pathways Induced by Injury Caused by FSGS Associated Circulating Factors

    P. Rashmi1, T. Sigdel1, D. Rychkov1, I. Damm1, F. Vincenti1, C. Craik1, J. Reiser2, M. Sarwal1

    1UCSF, San Francisco, CA, 2Rush University, Chicago, IL

    *Purpose: Focal segmental glomerulosclerosis (FSGS) remains a disease without specific therapy for primary disease and a high rate of recurrence after renal transplant. Circulating factors…
  • 2022 American Transplant Congress

    Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Cells

    A. R. Gupta1, J. Wang2, C. Lareau3, I. Sun2, J. Bautista1, J. Gardner1

    1Department of Surgery, University of California San Francisco, San Francisco, CA, 2Diabetes Center, University of California San Francisco, San Francisco, CA, 3Department of Pathology, Stanford University, Stanford, CA

    *Purpose: The Autoimmune Regulator (Aire) gene, essential for central tolerance through its regulation of tissue-specific antigens in medullary thymic epithelial cells, is also expressed in…
  • 2022 American Transplant Congress

    Local Intragraft Humoral Immune Response in Chronic Lung Allograft Dysfunction

    E. Miyamoto1, S. C. Juvet2, D. Vosoughi2, J. Wang2, J. Al-Refaee2, T. Daigneault2, A. Duong2, S. Moshkelgosha2, S. Keshavjee2, K. Tinckam2, A. Chruscinski3, D. Hwang4, T. Martinu2

    1Tenri Hospital Japan, University Health Network Canada, Nara, Japan, 2University Health Network, Toronto, ON, Canada, 3Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, 4Sunnybrook Health Science Centre, Toronto, ON, Canada

    *Purpose: Donor HLA-specific antibody (DSA) and antibody against self-antigens (self-antigen antibody) can cause injury and lead to chronic lung allograft dysfunction (CLAD) after lung transplantation…
  • 2021 American Transplant Congress

    A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of At-1501

    S. Perrin1, A. Gill2, C. Gill2, P. Gustafson1

    1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA

    *Purpose: Execute a phase 1 study of AT-1501 to assess safety, pharmacokinetics, and functional activity.*Methods: The study employed a placebo-controlled, sequential, dose-escalation design. 28 healthy…
  • 2021 American Transplant Congress

    Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-mediated Rejection

    S. Clotet-Freixas1, M. Kotlyar2, C. M. McEvoy1, C. Pastrello2, S. Rodríguez-Ramírez1, S. Farkona1, H. Cardinal3, M. Dieudé3, M. Hébert3, Y. Li1, O. Famure1, P. Chen1, S. Kim1, E. Chan4, I. Jurisica2, R. John1, A. Chruscinski1, A. Konvalinka1

    1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR) causes >50% of late kidney graft losses. Although donor-specific antibodies (DSA) against HLA cause AMR, antibodies against non-HLA antigens are also…
  • 2021 American Transplant Congress

    Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes

    D. A. Alagpulinsa, A. Jajoo, M. H. Chapin II, M. C. Poznansky

    Vaccine & Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…
  • 2021 American Transplant Congress

    Recurrence and Outcome of Anti-GBM Glomerulonephritis After Kidney Transplantation: A Belgian Multicenter Study

    S. Coche

    Nephrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium

    *Purpose: Recurrence of anti-glomerular basement membrane (anti-GBM) glomerulonephritis (GN) in the kidney graft is a rare event, described in limited case reports and registry analysis.…
  • 2021 American Transplant Congress

    Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy

    R. G. Gill1, M. Coulombe2, K. S. Beard1, A. L. Burrack3

    1University of Colorado, Aurora, CO, 2Surgery, University of Colorado, Aurora, CO, 3Mircrobiology and Immunology, University of Minnesota, Minneapolis, MN

    *Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…
  • 2020 American Transplant Congress

    Single versus Dual Immunosuppression in Liver Transplantation for Autoimmune Liver Diseases

    S. Sterling1, S. Hamel1, C. Garza1, I. Feurer2, S. Rega2, S. Alexopoulos3, M. Izzy4

    1Pharmacy, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt Transplant Center, Nashville, TN, 3Liver Transplant Surgery, Vanderbilt Transplant Center, Nashville, TN, 4Transplant Hepatology, Vanderbilt Transplant Center, Nashville, TN

    *Purpose: There is limited evidence on the optimal maintenance immunosuppression after liver transplant (LT) for primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and autoimmune…
  • 2020 American Transplant Congress

    T-cell Receptor Deep Sequencing to Distinguish Autoimmune Recurrence from Allograft Rejection in Liver Transplant Patients with Autoimmune Liver Disease

    K. J. Yang1, M. Martinez2, B. Shonts1, C. A. Parks1, A. Z. Obradovic1, T. M. Savage1, E. Spyrou1, S. Lau1, M. I. Colquhoun1, K. Rodgers1, E. Verna3, S. M. Coley4, S. Yang1, Y. Shen5, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Department of Medicine, Columbia University, New York, NY, 4Department of Pathology, Columbia University, New York, NY, 5Center for Computational Biology & Bioinformatics, Department of Systems Biology, Columbia University, New York, NY

    *Purpose: Patients who undergo liver transplantation for autoimmune liver disease (ALD) experience high rates of graft failure. The relative roles of recurrent ALD and rejection…
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