2022 American Transplant Congress
Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion
*Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…2022 American Transplant Congress
Cd137 on Host Dendritic Cells Fine-Tunes the Intesity of Donor T Cells in Systemic Alloinmmune Responses
*Purpose: CD137 is a potent costimulatory receptor for CD8+ T cells but it also regulates dendritic cells (DCs) to suppress immune responses. In this study,…2022 American Transplant Congress
Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression
1Baylor University, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX
*Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…2022 American Transplant Congress
Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation
*Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…2022 American Transplant Congress
The Pre-Transplant Non-HLA Antibody Burden Predicts the Development of Histology of Antibody-Mediated Rejection After Kidney Transplantation
*Purpose: Many kidney allografts fail due to the occurrence of antibody-mediated rejection (ABMR), related to donor-specific anti-HLA antibodies (HLA-DSA). However, the histology of ABMR can…2022 American Transplant Congress
Role for Club Cell Secretory Protein in Inducing Exosomes and Activation of Immune Responses in Lung Transplanted Recipients for Cystic Fibrosis
*Purpose: Our lab has demonstrated that lower club cell secretory protein leads to immune responses to donor HLA and lung self-antigens (Collagen V, Kα1 Tubulin),…2022 American Transplant Congress
Temporal Changes in the Peripheral Immune Profile of Acute Rejection Highlight New Mechanisms of Alloimmunity and Potential Non-Invasive Biomarkers of Rejection in Pediatric Liver Transplantation
*Purpose: Acute rejection (AR) is common in pediatric liver transplantation (LT) and can impact late graft loss. Immune subpopulations mediating AR in LT have not…2022 American Transplant Congress
Galectin-3 Expression in Autoimmune Hepatitis
*Purpose: Autoimmune hepatitis (AIH) is characterized by chronic inflammation in which healthy liver cells are targeted by one’s immune system. The persistent inflammatory milieu can…2022 American Transplant Congress
Protein and Transcriptomic Differences Between High and Low Neointimal Arteries in Human Cardiac Allograft Vasculopathy Rejected Grafts
*Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of graft failure and mortality following heart transplantation. Donor specific antibodies (DSA) contribute to CAV progression…2022 American Transplant Congress
Perturbations in Podocyte Transcriptome and Biological Pathways Induced by Injury Caused by FSGS Associated Circulating Factors
1UCSF, San Francisco, CA, 2Rush University, Chicago, IL
*Purpose: Focal segmental glomerulosclerosis (FSGS) remains a disease without specific therapy for primary disease and a high rate of recurrence after renal transplant. Circulating factors…
- 1
- 2
- 3
- …
- 10
- Next Page »