Articles tagged "Area-under-curve (AUC)"

2018 American Transplant Congress
Absolute Quantification of Plasma Graft-Derived Cell-Free DNA for Diagnosis of Kidney Transplant Rejection
J. Whitlam,¹ L. Ling,² F. Ierino,³ D. Bruno,² H. Slater,² D. Power.¹
¹Austin Health, Heidelberg, Victoria, Australia; ²Murdoch Childrens Research Institute, Parkville, Victoria, Australia; ³St Vincent's Health, Fitzroy, Victoria, Australia.
Aim: To study the performance of droplet digital PCR absolute measurement of graft-derived cell-free DNA (gdcfDNA) for the diagnosis of kidney allograft rejection.Methods: Homozygous deletion…
2018 American Transplant Congress
Outcomes from Brain Death Donors with Cardiac Arrest Accepted for Pancreas Transplantation
P. Ventura-Aguiar,¹ J. Ferrer,² D. Paredes,³ C. Rodriguez,³ C. Fontdevilla,² E. Esmatjes,⁴ J. Garcia-Valdecasas,² F. Oppenheimer,¹ F. Diekmann,¹ M. Ricart.¹
¹Nephrology and Kidney Transplant Department, Hospital Clinic, Barcelona, Spain; ²Hepatobiliopancreatic and Liver Transplant Department, Hospital Clinic, Barcelona, Spain; ³Organ Transplantation Coordination Department, Hospital Clinic, Barcelona, Spain; ⁴Diabetes Unit, Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain.
Donor selection has a major impact on pancreas transplantation. Cardiac arrest and hypoxemia produce an insult to endothelial cell and may increase the risk of…
2018 American Transplant Congress
Evaluating PROMIS-57 Domains to Screen for Anxiety and Depression Using Legacy Instruments among Kidney Transplant Recipients
A. Bansal,¹ O. Ekundayo,¹ E. Tang,¹ F. Khalafi,¹ H. Ford,¹ M. Li,³ M. Novak,² I. Mucsi.¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Centre for Mental Health, University Health Network, Toronto, ON, Canada; ³Department of Supportive Care, Princess Margaret Hospital, Toronto, ON, Canada.
BACKGROUNDDepression and anxiety are frequent among kidney transplant recipients (KTRs). We evaluate the accuracy of the Patient Reported Outcomes Measurement System (PROMIS 57 item) depression…
2018 American Transplant Congress
Discriminative Accuracy of Physician Assessments of Kidney Transplant Candidate Function by Candidate Age, Sex, and Race
M. Harhay,¹ K. Ranganna,¹ L. Levin Mizrahi,¹ G. Xiao,¹ G. Malat,¹ D. Reich,¹ S. Guy,¹ P. Reese.²
¹Drexel University College of Medicine, Philadelphia, PA; ²Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Background: Clinical assessments of patient health status are integral in kidney transplant (KT) waiting list management. Few data exist on the whether the accuracy of…
2018 American Transplant Congress
A Novel Combined Formula to Direct Optimal Immunosuppressive Drug Exposure in Renal Transplant Recipients
O. Pankewycz,¹ E. Onan,² M. Laftavi,¹ R. Gruessner,³ H. Smileuski,¹ E. Alissandrello,¹ A. Gruessner.³
¹Upstate Medical University, Syracuse, NY; ²Cukurova University, Adana, Turkey; ³Downstate Medical University, New York, NY.
Purpose: The most widely used maintenance immunosuppressive combination after kidney transplantation is tacrolimus (TAC) and mycophenolic acid (MPA). The utility of therapeutic drug monitoring for…
2018 American Transplant Congress
Belatacept and Tacrolimus Corticosteroid-Free Regimens Lead to Elevated Mycophenolic Acid Exposure at 1 and 3 Months after Kidney Transplantation
A. Dao, S. Tremblay, A. Shields, A. Loethen, B. Abu Jawdeh, T. Diwan, A. Govil, E. Woodle, R. Alloway.
UCincinnati, Cincinnati.
Mycophenolate mofetil (MMF) is generally administered as a fixed dose. Studies have shown a relationship between MPA exposure (MPAAUC) but no data evaluates this relationship…
2018 American Transplant Congress
Development of Optimal Simplified Equation for Estimation of Mycophenolic Acid Exposure Following Enteric-Coated Mycophenolate Sodium Administration in Chinese Renal Transplant Recipients
W. Peng, C. Tian, Z. Chen, W. Xue, G. Wang, Q. Ye, X. Zhang, M. Gu, M. Zhao, C. Wang, C. Huang, J. Yan, W. Zhang, C. Ding, Y. Fu, S. Ye, X. Hu, R. Tan, M. Li, R. Deng, Y. Ke, W. Wu, M. Fan, J. Chen.
MyERA Study Group, Hangzhou, China.
Background: Limited sampling strategies (LSS) aids in overcoming the complexity of extensive PK sampling and supporting the calculation of mycophenolic acid (MPA) exposure. This study…
2017 American Transplant Congress
Model to Predict Prolonged Delayed Graft Function (DGF) Following Kidney Transplantation from Deceased Donor with Acute Kidney Injury (AKI Tx).
R. Heilman,¹ B. Smith,² C. Johnson,¹ H. Khamash,¹ K. Reddy,¹ W. Kremers,² B. Kaplan.¹
¹Mayo Clinic, Phoenix, AZ; ²Mayo Clinic, Rochester, MN
Background Our aim is to develop a model to predict prolonged DGF following AKI Tx.Methods AKI Tx (donor terminal Cr>/=2) from 2003 to 2016 were…
2017 American Transplant Congress
An Analysis of Tacrolimus XL Dosing in Obese Kidney Transplant Recipients.
N. Jasiak, J. Thielke, K. Progar, J. Chen, C. Adams, E. Benedetti, P. West-Thielke.
Univ of Ill, Chicago
Background:Tacrolimus extended-release (XL) is utilized in many immunosuppressive regimens post-kidney transplantation. Current dosing recommendation for the XL formulation in renal transplant (txp) is 0.15 mg/kg/day…
2017 American Transplant Congress
Once-Daily versus Twice-Daily Tacrolimus in Living Kidney Transplantation: A Multicenter, Parallel Group, Open-Label, 5-Year, Randomized Non-Inferiority Trial.
K. Unagami,¹ M. Okumi,² T. Hirai,² D. Toki,³ H. Shirakawa,⁴ T. Shimizu,² K. Omoto,⁵ M. Inui,³ H. Ishida,² K. Nitta,¹ K. Tanabe.²
¹Nephrology, Tokyo Women's Medical University, Tokyo, Japan; ²Urology, Tokyo Women's Medical University, Tokyo, Japan; ³Urology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan; ⁴Urology, Ohkubo Hospital, Tokyo, Japan; ⁵Transplant Surgery, Toda Chuo General Hospital, Toda, Japan
Background:Tacrolimus (TAC)-based induction therapy appears to be the standard immunosuppressive regimen for most kidney transplantation recipients (KTRs). TAC is available as a twice-daily (TAC-BID) and…