ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Area-under-curve (AUC)"

  • 2019 American Transplant Congress

    An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation

    E. Van Loon1, S. Gazut2, S. Yazdani1, E. Lerut1, H. de Loor1, M. Coemans1, L. Noël3, L. Thorrez1, L. Van Lommel1, F. Schuit1, D. Lambrechts1, T. Van Brussel1, B. Sprangers1, D. Kuypers1, M. Essig4, W. Gwinner5, D. Anglicheau6, P. Marquet7, M. Naesens1

    1Catholic University Leuven, Leuven, Belgium, 2CEA, Gif-sur-Yvette, France, 3Necker-Enfants Malades Institute, Paris, France, 4CHU Limoges, Limoges, France, 5Hannover Medical School, Hannover, Germany, 6Paris Descartes, Sorbonne Paris Cité University, Paris, France, 7RTRS Centaure, Necker Hospital, Paris, France

    *Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…
  • 2019 American Transplant Congress

    The Impact of KDPI on Post Transplant Kidney Function: Intercept versus Slope. A Single Center Study

    M. Molinari1, D. Jorgensen2, R. Mehta3, P. Sood3, A. Ganoza2, C. Puttarajappa3, R. Lopez2, M. Wijkstrom2, A. Tevar2, S. Hariharan3

    1University of Pittsburgh Medical Centre, Pittsburgh, PA, 2Surgery, University of Pittsburgh Medical Centre, Pittsburgh, PA, 3Medicine, University of Pittsburgh Medical Centre, Pittsburgh, PA

    *Purpose: We evaluated the impact of Kidney Donor Profile Index (KDPI) on post-transplant renal function and graft survival.*Methods: Between January-2013 and December- 2017, a total…
  • 2019 American Transplant Congress

    Comparison between Urine and Blood NGAL for Early Prediction of Delayed Graft Function in Adult Kidney Transplant Recipients: A Systematic Review and Meta-Analysis

    Y. Li, Y. Li, L. Yan, H. Wang, X. Wu, J. Tang, L. Wang, Y. Shi

    Department of Laboratory Medicine, West China Hospital, Chengdu, China

    *Purpose: Neutrophil gelatinase-assoicated lipocalin (NGAL) appears to be a promising proximal tubular injury biomarker for early prediction of delayed graft function (DGF) in kidney transplant…
  • 2019 American Transplant Congress

    Mycophenolic Acid Area under the Curve Monitoring via Limited Sampling Strategy in Pediatric Heart Transplant Recipients

    S. Crow, S. H. Dahl, J. N. Johnson

    Mayo Clinic, Rochester, MN

    *Purpose: The study aim was to investigate exposure to mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), after pediatric orthotopic heart transplantation (pOHT).…
  • 2019 American Transplant Congress

    Evaluation of Mycophenolate Mofetil Exposure in Renal Transplant Recipients

    M. C. Ott1, S. Mietz2, S. Chang3

    1Department of Pharmaceutical Services, Erie County Medical Center, Buffalo, NY, 2Department of Pharmacy, Indiana University Health, Indianapolis, IN, 3Department of Medicine, Jacobs School of Medicine & Biomedical Sciencess, Buffalo, NY

    *Purpose: Mycophenolate mofetil (MMF) is the most commonly prescribed immunosuppressant following transplantation in the United States. However, the occurrence of MMF therapy-related adverse events including…
  • 2018 American Transplant Congress

    Evaluation of Multiple Linear Regression Limited Sampling Strategies for Enteric-Coated Mycophenolate Sodium in Adult Kidney Transplant Recipients

    C. Staatz,1 E. Brooks,1 N. Isbel,2 B. McWhinney,3 S. Tett.1

    1Pharmacy, University of Queensland, Brisbane, QLD, Australia; 2Department of Nephrology, Princess Alexandra Hospital, Brisbane, QLD, Australia; 3Department of Pathology, The Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

    Background: Although multiple linear regression-based limited sampling strategies (LSS) have been published for enteric-coated mycophenolate sodium none have been evaluated for prediction of subsequent mycophenolic…
  • 2018 American Transplant Congress

    Pharmacokinetics of Mycophenolic Acid Following Enteric-Coated Mycophenolate Sodium Administration in Chinese Renal Transplant Recipients

    W. Peng, C. Tian, Z. Chen, W. Xue, G. Wang, Q. Ye, X. Zhang, M. Gu, M. Zhao, C. Wang, C. Huang, J. Yan, W. Zhang, C. Ding, Y. Fu, S. Ye, X. Hu, R. Tan, M. Li, R. Deng, Y. Ke, W. Wu, M. Fan, J. Chen.

    MyERA Study Group, Hangzhou, China.

    Background: Mycophenolic acid (MPA), active component of mycophenolate mofetil (MMF) or enteric-coated mycophenolate sodium (EC-MPS), is the most commonly used immunosuppressant in renal transplant recipients…
  • 2018 American Transplant Congress

    The Combination of Area under Curve of Estimated Glomerular Filtration Rate for 2 Years and Annual Rate Change of Estimated Glomerular Filtration Rate Predicts Long-Term Graft Survival in Kidney Transplants

    E. Lee,1 J. Jeon,1 S. Kim,1 M. Kim,1 K. Lee,1 H. Jang,1 J. Lee,1 J. Hwang,2 D. Kim,1 Y-.G. Kim,1 H. Oh,1 W. Huh,1 J. Kim.3

    1Department of Medicine, Samsung Medical Center, Seoul, Republic of Korea; 2Department of Anesthesiology and Pain Medicine, Seoul National University BunDang Hospital, Sungnam, Republic of Korea; 3Department of Surgery, Samsung Medical Center, Seoul, Republic of Korea.

    Improvement of short-term outcomes in kidney transplant (KT) has required clinical trials to evaluate long-term hard outcomes for validation of new therapies. However, because of…
  • 2018 American Transplant Congress

    Improving Prediction of Post-Transplant Death and Graft Loss with Expanded Clinical Data Collection

    R. Sung,1 J. Magee,1 M. Schnitzler,2 N. Dzebisashvili,3 K. Lentine,2 L. Ly,1 D. Axelrod.4

    1University of Michigan, Ann Arbor; 2Saint Louis University, St. Louis; 3XynManagement, Inc, St. Louis.

    US transplant centers are graded for patient and graft survival of their recipients based on comparison to risk-adjusted expectations using elements captured in the national…
  • 2018 American Transplant Congress

    Identification of Noninvasive and Mechanistically-Informative Biomarkers Predictive of Reversal of Acute Cellular Rejection (ACR) in Kidney Allografts

    D. Luan,1 J. Schwartz,2 R. Ding,2 T. Muthukumar,2 D. Dadhania,2 M. Suthanthiran.2

    1University of Michigan, Ann Arbor, MI; 2Weill Cornell Medical College, New York City, NY.

    Objective: We determined whether urinary cell mRNAs predict response to anti-rejection therapy in kidney allograft recipients with Banff grade IA or higher ACR biopsies.Methods: We…
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