Articles tagged "Area-under-curve (AUC)"

2019 American Transplant Congress
The Impact of KDPI on Post Transplant Kidney Function: Intercept versus Slope. A Single Center Study
M. Molinari¹, D. Jorgensen², R. Mehta³, P. Sood³, A. Ganoza², C. Puttarajappa³, R. Lopez², M. Wijkstrom², A. Tevar², S. Hariharan³
¹University of Pittsburgh Medical Centre, Pittsburgh, PA, ²Surgery, University of Pittsburgh Medical Centre, Pittsburgh, PA, ³Medicine, University of Pittsburgh Medical Centre, Pittsburgh, PA
*Purpose: We evaluated the impact of Kidney Donor Profile Index (KDPI) on post-transplant renal function and graft survival.*Methods: Between January-2013 and December- 2017, a total…
2019 American Transplant Congress
Comparison between Urine and Blood NGAL for Early Prediction of Delayed Graft Function in Adult Kidney Transplant Recipients: A Systematic Review and Meta-Analysis
Y. Li, Y. Li, L. Yan, H. Wang, X. Wu, J. Tang, L. Wang, Y. Shi
Department of Laboratory Medicine, West China Hospital, Chengdu, China
*Purpose: Neutrophil gelatinase-assoicated lipocalin (NGAL) appears to be a promising proximal tubular injury biomarker for early prediction of delayed graft function (DGF) in kidney transplant…
2019 American Transplant Congress
Mycophenolic Acid Area under the Curve Monitoring via Limited Sampling Strategy in Pediatric Heart Transplant Recipients
S. Crow, S. H. Dahl, J. N. Johnson
Mayo Clinic, Rochester, MN
*Purpose: The study aim was to investigate exposure to mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), after pediatric orthotopic heart transplantation (pOHT).…
2019 American Transplant Congress
Evaluation of Mycophenolate Mofetil Exposure in Renal Transplant Recipients
M. C. Ott¹, S. Mietz², S. Chang³
¹Department of Pharmaceutical Services, Erie County Medical Center, Buffalo, NY, ²Department of Pharmacy, Indiana University Health, Indianapolis, IN, ³Department of Medicine, Jacobs School of Medicine & Biomedical Sciencess, Buffalo, NY
*Purpose: Mycophenolate mofetil (MMF) is the most commonly prescribed immunosuppressant following transplantation in the United States. However, the occurrence of MMF therapy-related adverse events including…
2019 American Transplant Congress
An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation
E. Van Loon¹, S. Gazut², S. Yazdani¹, E. Lerut¹, H. de Loor¹, M. Coemans¹, L. Noël³, L. Thorrez¹, L. Van Lommel¹, F. Schuit¹, D. Lambrechts¹, T. Van Brussel¹, B. Sprangers¹, D. Kuypers¹, M. Essig⁴, W. Gwinner⁵, D. Anglicheau⁶, P. Marquet⁷, M. Naesens¹
¹Catholic University Leuven, Leuven, Belgium, ²CEA, Gif-sur-Yvette, France, ³Necker-Enfants Malades Institute, Paris, France, ⁴CHU Limoges, Limoges, France, ⁵Hannover Medical School, Hannover, Germany, ⁶Paris Descartes, Sorbonne Paris Cité University, Paris, France, ⁷RTRS Centaure, Necker Hospital, Paris, France
*Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…
2018 American Transplant Congress
Improving Prediction of Post-Transplant Death and Graft Loss with Expanded Clinical Data Collection
R. Sung,¹ J. Magee,¹ M. Schnitzler,² N. Dzebisashvili,³ K. Lentine,² L. Ly,¹ D. Axelrod.⁴
¹University of Michigan, Ann Arbor; ²Saint Louis University, St. Louis; ³XynManagement, Inc, St. Louis.
US transplant centers are graded for patient and graft survival of their recipients based on comparison to risk-adjusted expectations using elements captured in the national…
2018 American Transplant Congress
Identification of Noninvasive and Mechanistically-Informative Biomarkers Predictive of Reversal of Acute Cellular Rejection (ACR) in Kidney Allografts
D. Luan,¹ J. Schwartz,² R. Ding,² T. Muthukumar,² D. Dadhania,² M. Suthanthiran.²
¹University of Michigan, Ann Arbor, MI; ²Weill Cornell Medical College, New York City, NY.
Objective: We determined whether urinary cell mRNAs predict response to anti-rejection therapy in kidney allograft recipients with Banff grade IA or higher ACR biopsies.Methods: We…
2018 American Transplant Congress
Absolute Quantification of Plasma Graft-Derived Cell-Free DNA for Diagnosis of Kidney Transplant Rejection
J. Whitlam,¹ L. Ling,² F. Ierino,³ D. Bruno,² H. Slater,² D. Power.¹
¹Austin Health, Heidelberg, Victoria, Australia; ²Murdoch Childrens Research Institute, Parkville, Victoria, Australia; ³St Vincent's Health, Fitzroy, Victoria, Australia.
Aim: To study the performance of droplet digital PCR absolute measurement of graft-derived cell-free DNA (gdcfDNA) for the diagnosis of kidney allograft rejection.Methods: Homozygous deletion…
2018 American Transplant Congress
Outcomes from Brain Death Donors with Cardiac Arrest Accepted for Pancreas Transplantation
P. Ventura-Aguiar,¹ J. Ferrer,² D. Paredes,³ C. Rodriguez,³ C. Fontdevilla,² E. Esmatjes,⁴ J. Garcia-Valdecasas,² F. Oppenheimer,¹ F. Diekmann,¹ M. Ricart.¹
¹Nephrology and Kidney Transplant Department, Hospital Clinic, Barcelona, Spain; ²Hepatobiliopancreatic and Liver Transplant Department, Hospital Clinic, Barcelona, Spain; ³Organ Transplantation Coordination Department, Hospital Clinic, Barcelona, Spain; ⁴Diabetes Unit, Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain.
Donor selection has a major impact on pancreas transplantation. Cardiac arrest and hypoxemia produce an insult to endothelial cell and may increase the risk of…
2018 American Transplant Congress
Evaluating PROMIS-57 Domains to Screen for Anxiety and Depression Using Legacy Instruments among Kidney Transplant Recipients
A. Bansal,¹ O. Ekundayo,¹ E. Tang,¹ F. Khalafi,¹ H. Ford,¹ M. Li,³ M. Novak,² I. Mucsi.¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Centre for Mental Health, University Health Network, Toronto, ON, Canada; ³Department of Supportive Care, Princess Margaret Hospital, Toronto, ON, Canada.
BACKGROUNDDepression and anxiety are frequent among kidney transplant recipients (KTRs). We evaluate the accuracy of the Patient Reported Outcomes Measurement System (PROMIS 57 item) depression…