Articles tagged "Apoptosis"

2018 American Transplant Congress
In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury
I. Linares,¹ A. Bartczak,¹ K. Farrokhi,¹ D. Kollmann,¹ M. Kaths,¹ M. Hamar,¹ P. Urbanellis,¹ S. Ganesh,¹ O. Adeyi,² P. Yip,³ M. Selzner,¹ N. Selzner.¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; ²Department of Pathology, Toronto General Hospital, Toronto, ON, Canada; ³Laboratory of Medicine and Pathobiology, Toronto General Hospital, Toronto, ON, Canada.
Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…
2018 American Transplant Congress
Overexpression of BAX, NOL3, and XIAP Apoptotic Genes Participates in Calcineurin Inhibitors Nephrotoxicity: New Insights into Chronic Allograft Dysfunction
L. Garcia-Covarrubias,¹ G. Queipo,² M. Fonseca,² D. Alcantara,¹ P. Prieto,¹ H. Diliz,¹ A. Garcia,¹ H. Hinojosa,¹ A. Cicero,¹ G. Melendez,³ M. Alamilla,³ R. Lascurain,⁴ V. Soto.⁵
¹Transplantation, Hospital General de Mexico, Mexico City, Mexico; ²Genetics, Hospital General de Mexico, Mexico City, Mexico; ³Research, Hospital General de Mexico, Mexico City, Mexico; ⁴Faculty of Medicine, UNAM, Mexico City, Mexico; ⁵Pathology, Hospital General de Mexico, Mexico City, Mexico.
Introduction: Calcineurin inhibitors toxicity (CNIT) is a factor that limit the outcome of renal transplantation graft. The hypoxia causes histological data as nodular hyalinosis, hyalinosis,…
2018 American Transplant Congress
Noninvasive Detection of Infection and Rejection in Renal Transplant Patients
Y. Zhou,¹ Y. Cheng,¹ T. Chiang,² G. Yang,² X. Li,² F. Zeng,² X. Wang,¹ J. Ge,² X. Hu,² H. Shi,¹ T. Wang,² L. Liu.³
¹Laboratory of Transplant Genomics, Jiangsu University Institute of Life Science, ZhenJiang, JingSu, China; ²Reasearch and Development Dpartment, SuZhou RRGene.Co.Ltd., SuZhou, JiangSu, China; ³Department of Urological Organ Transplantation, The Second XiangYa Hospital of Center South University, ChangSha, Hunan, China.
About 35% of patients would suffer actue rejection or infectionin in two years after reanl trandplantation.Cell-free DNA (cfDNA) is a new biomarker to evluate health…
2018 American Transplant Congress
Insulin Use on Intensive Care Units as a Marker of beta-Cell Death in Brain Dead Pancreas Donors
M. Shapey,^1,2 A. Summers,² J. O'Sullivan,² P. Yianoullou,^1,2 T. Augustine,² M. Rutter,¹ D. van Dellen.²
¹Division of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester, United Kingdom; ²Department of Renal and Pancreatic Transplantation, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
IntroductionObjective methods for assessing the quality of pancreata for transplantation are urgently required. Donors after brain death (DBD) experience a catecholamine storm and systemic inflammation,…
2018 American Transplant Congress
α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts
G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, C. Wang, J. Zhang, F. Ning, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Previous study has shown that intravenous infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) can induce tolerance of mice cardiac allografts with rapidly apoptosis of ECDI-SPs…
2018 American Transplant Congress
Assessing the Impact of Flow in Hypothermic Machine Perfusion on Human Venous Endothelium Using a Novel Ex Vivo Model
Y. Marie,¹ W. Ries,² K. Patel,¹ C. Turnbull,² N. Jamil,⁴ H. Caldwell,³ R. Telfer,² D. Neil,⁵ J. Nath,¹ N. Inston.¹
¹Department of Renal Surgery, Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom; ²College of Medical and Dental Sciences, University of Birmingham, Birmingham, West Midlands, United Kingdom; ³Division of Pathology Laboratories, Western General Hospital, Edinburgh, United Kingdom; ⁴Department of Cellular Pathology, Durham and Darlington NHS Foundation Trust, Newcastle, Newcastle Upon Tyne, United Kingdom; ⁵Department of Histopathology, University Hospitals Birmingham NHS Trust, Birmingham, West Midlands, United Kingdom.
BACKGROUNDHypothermic machine perfusion (HMP) involves dynamic flow of chilled preservation fluid through an allograft's vasculature. This study describes a simple, reproducible, human model that allows…
2018 American Transplant Congress
In Vivo Administration of Plerixafor and Bortezomib Results in Bone Marrow Plasma Cell Mobilization and Death While Inducing Biphasic Plasma Cell Apoptosis in Peripheral Blood
E. Woodle,¹ S. Tremblay,¹ C. Castro-Rojas,² S. Knechtle,³ A. Shields,¹ R. Alloway,¹ H. Singh,² J. Driscoll,¹ D. Hildeman.²
¹U Cincinnati, Cincinnati; ²Cincinnati Children's, Cincinnati; ³Duke, Durham.
Bone marrow (BM) plasma cells (PC) secreting HLA antibody (Ab) remain a persistent reservoir of donor specific Ab and present a significant hurdle to allograft…
2018 American Transplant Congress
NFkB Inhibitor Improves Glycemic Control after Syngeneic Islet Transplantation by Suppression of Proinflammatory and Apoptotic Gene Expression in a Cerulein-Induced Pancreatitis Model
G. Yoshimatsu,¹ C. Darden,² K. Kumano,² C. Chang,² P. Saravanan,² M. Lawrence,² B. Naziruddin.³
¹Fukuoka University, Fukuoka, Japan; ²Baylor Scott and White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis. Repeated or continuous pancreatitis attack leads islet damage beyond inflamed exocrine…
2018 American Transplant Congress
Exenatide Reduces Ischemia/Reperfusion Injury in Donation after Cardiac Death Rat Kidney Transplantation
H. Yang,¹ Y. Shi,² X. Li,¹ C. Long,¹ Z. Xu,¹ L. Luo,¹ W. Luo,¹ Y. Zhang,¹ T. Zeng,³ M. Chen,⁴ H. Li,⁵ Z. Wang.⁵
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China; ³Department of Urologic Surgery, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; ⁵Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Background: Exenatide provide protection against warm Ischemia/Reperfusion Injury (IRI) in the rat heart and kidney. We hypothesized that Exenatide reduces IRI in a rat donation…
2018 American Transplant Congress
Recombinant Relaxin Protects Liver Transplants from Ischemia-Reperfusion Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside
S. Kageyama,¹ K. Nakamura,¹ T. Ito,¹ A. Aziz,¹ B. Ke,¹ R. Sossa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Division of Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the…

« Previous Page
1
…
5
6
7
8
9
…
13
Next Page »