Articles tagged "Apoptosis"

2018 American Transplant Congress
Exenatide Reduces Ischemia/Reperfusion Injury in Donation after Cardiac Death Rat Kidney Transplantation
H. Yang,¹ Y. Shi,² X. Li,¹ C. Long,¹ Z. Xu,¹ L. Luo,¹ W. Luo,¹ Y. Zhang,¹ T. Zeng,³ M. Chen,⁴ H. Li,⁵ Z. Wang.⁵
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China; ³Department of Urologic Surgery, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; ⁵Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Background: Exenatide provide protection against warm Ischemia/Reperfusion Injury (IRI) in the rat heart and kidney. We hypothesized that Exenatide reduces IRI in a rat donation…
2018 American Transplant Congress
Recombinant Relaxin Protects Liver Transplants from Ischemia-Reperfusion Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside
S. Kageyama,¹ K. Nakamura,¹ T. Ito,¹ A. Aziz,¹ B. Ke,¹ R. Sossa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Division of Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the…
2018 American Transplant Congress
GDF15 Preventing Renal Ischemia Reperfusion Injury
C. Zhu,^1,2 A. Patel,¹ Y. Su,^1,2 J. Jiang,¹ D. Lian,¹ A. Sener,¹ W. Min,¹ P. Luke,¹ D. Quan,¹ K. Liu,² X. Zheng.¹
¹University of Western Ontario, London, ON, Canada; ²Jilin University, ChangChun, China.
Rationale: Ischemia reperfusion (I/R) injury still remains one of main causes of early renal dysfunction in kidney transplantation. There are no effective treatments for preventing…
2018 American Transplant Congress
QPI-1002, a siRNA Targeting p53: Improvement in Outcomes Following Acute Kidney Injury (AKI): Cardiac Surgery to AKI Donors
J. Tchervenkov,² E. Squiers,¹ R. Stratta,³ D. Odenheimer,² D. Rothenstein,² QPI-1002 DGF Study Group.
¹Quark Pharmaceuticals, Fremont; ²McGill University Health, Montreal, Canada; ³Wake Forest School of Medicine Centre, Winston-Salem.
Background: QPI-1002 has been observed to statistically reduce the incidence, severity and duration of AKI in a large Phase 2 study of AKI following cardiac…
2018 American Transplant Congress
Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity
F. Migneault,^1,2,4 M. Dieudé,^1,2,4 J. Turgeon,^1,4 D. Beillevaire,^1,2,4 M-.P. Hardy,^2,3,4 C. Perreault,^2,3,4 M-.J. Hébert.^1,2,4
¹CRCHUM, Montreal, QC, Canada; ²Université de Montréal, Montreal, QC, Canada; ³IRIC, Montreal, QC, Canada; ⁴CNTRP, Montreal, QC, Canada.
Acute vascular rejection of renal allografts is associated with increased endothelial apoptosis which contributes to the development of transplant vasculopathy. We previously showed that apoptotic…
2018 American Transplant Congress
Recombinant Thrombomodulin alpha Attenuates Kidney Graft Damage after Long Cold Ischemia Time in a Rat Kidney Transplant Model
S. Tamaki,¹ K. Shinoda,¹ M. Shimoda,² S. Morita,¹ H. Asanuma,¹ M. Oya.¹
¹Urology, Keio University School of Medicine, Tokyo, Japan; ²Pathology, Keio University School of Medicine, Tokyo, Japan.
Objectives: Thrombomodulin (TM) extensively expresses on the endothelial cells in the steady state and is known to prevent hypercoagulation via combining with thrombin and inactivating…
2018 American Transplant Congress
Linking Donor Ischemia Reperfusion Injury (IRI) to Costimulatory Blockade Resistant Murine Heart Graft Rejection through Complement-Initiated Necroptosis
R. Ang, N. Chun, A. Ting, P. Heeger.
Immunology Institute, Translational Transplant Research, Icahn School of Medicine at Mount Sinai, New York, NY.
We previously showed that prolonged cold ischemic storage (CIS) of donor B6 hearts results in complement dependent, CTLA4Ig-resistant rejection in BALB/c recipients. In this system,…
2018 American Transplant Congress
MERTK Mediates Transplant Tolerance via IFN-a Regulation of MDSCs and Tregs
L. Zhang, M. DeBerge, E. Thorp, X. Luo.
Northwestern University Feinberg School of Medicine, Chicago.
Introduction: MERTK is one of the TAM receptor tyrosine kinases (RTKs) that mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune…
2018 American Transplant Congress
Enhancement of Intrinsic Apoptosis via Bcl-2 Inhibition Promotes Induction of Robust Mixed Chimerism and Renal Allograft Tolerance without Myelosuppression in Nonhuman Primates
T. Oura,¹ A. Dehnadi,¹ I. Rosales,¹ H. Sasaki,¹ P. Cippa,² R. Fehr,² A. Cosimi,¹ T. Kawai.¹
¹Surgery, Center for Transplantation Science, Massachusetts General Hospital, Boston, MA; ²Medicine, University of Zurich, Zurich, Switzerland.
Background: Successful induction of mixed chimerism (MC) and renal allograft tolerance has been achieved in both nonhuman primate (NHP) and man following conditioning that included…
2018 American Transplant Congress
Involvement of Aldehyde Dehydrogenase 2 (ALDH2) in Fatty Liver Graft Protection Mechanisms against Cold Ischemic Injury
A. Panisello-Rosello,¹ A. Lopez,² C. Castro,² S. Bellogi,¹ E. Folch-Puy,¹ A. Rolo,³ C. Palmeira,³ R. Adam, J. Roselló-Catafau.
¹Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona, Barcelona, Catalonia, Spain; ²INSERM U935, Hôpital Paul Brousse, Paris, France; ³Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Aldehyde dehydogenase (ALDH2) is a mitochondrial enzyme that recently has been involved in the cardioprotection against ischemia injury. No data are reported on the potential…

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