2018 American Transplant Congress
Linking Donor Ischemia Reperfusion Injury (IRI) to Costimulatory Blockade Resistant Murine Heart Graft Rejection through Complement-Initiated Necroptosis
We previously showed that prolonged cold ischemic storage (CIS) of donor B6 hearts results in complement dependent, CTLA4Ig-resistant rejection in BALB/c recipients. In this system,…2018 American Transplant Congress
MERTK Mediates Transplant Tolerance via IFN-a Regulation of MDSCs and Tregs
Northwestern University Feinberg School of Medicine, Chicago.
Introduction: MERTK is one of the TAM receptor tyrosine kinases (RTKs) that mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune…2018 American Transplant Congress
Enhancement of Intrinsic Apoptosis via Bcl-2 Inhibition Promotes Induction of Robust Mixed Chimerism and Renal Allograft Tolerance without Myelosuppression in Nonhuman Primates
Background: Successful induction of mixed chimerism (MC) and renal allograft tolerance has been achieved in both nonhuman primate (NHP) and man following conditioning that included…2018 American Transplant Congress
Involvement of Aldehyde Dehydrogenase 2 (ALDH2) in Fatty Liver Graft Protection Mechanisms against Cold Ischemic Injury
Aldehyde dehydogenase (ALDH2) is a mitochondrial enzyme that recently has been involved in the cardioprotection against ischemia injury. No data are reported on the potential…2018 American Transplant Congress
In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury
Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…2018 American Transplant Congress
Overexpression of BAX, NOL3, and XIAP Apoptotic Genes Participates in Calcineurin Inhibitors Nephrotoxicity: New Insights into Chronic Allograft Dysfunction
Introduction: Calcineurin inhibitors toxicity (CNIT) is a factor that limit the outcome of renal transplantation graft. The hypoxia causes histological data as nodular hyalinosis, hyalinosis,…2018 American Transplant Congress
Noninvasive Detection of Infection and Rejection in Renal Transplant Patients
About 35% of patients would suffer actue rejection or infectionin in two years after reanl trandplantation.Cell-free DNA (cfDNA) is a new biomarker to evluate health…2018 American Transplant Congress
Insulin Use on Intensive Care Units as a Marker of beta-Cell Death in Brain Dead Pancreas Donors
IntroductionObjective methods for assessing the quality of pancreata for transplantation are urgently required. Donors after brain death (DBD) experience a catecholamine storm and systemic inflammation,…2018 American Transplant Congress
α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts
Previous study has shown that intravenous infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) can induce tolerance of mice cardiac allografts with rapidly apoptosis of ECDI-SPs…2018 American Transplant Congress
Assessing the Impact of Flow in Hypothermic Machine Perfusion on Human Venous Endothelium Using a Novel Ex Vivo Model
BACKGROUNDHypothermic machine perfusion (HMP) involves dynamic flow of chilled preservation fluid through an allograft's vasculature. This study describes a simple, reproducible, human model that allows…
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